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ENZYME

ENZYME entry: EC 2.5.1.3

Accepted Name
thiamine phosphate synthase
Alternative Name(s)
thiamine-phosphate diphosphorylase
thiamine-phosphate pyrophosphorylase
thiamine-phosphate synthase
TMP diphosphorylase
TMP pyrophosphorylase
Reaction catalysed
  • 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
  • 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
  • 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate
Comment(s)
  • The enzyme catalyzes the penultimate reaction in thiamine de novo biosynthesis, condensing the pyrimidine and thiazole components.
  • The enzyme is thought to accept the product of EC 2.8.1.10 as its substrate.
  • However, it has been shown that in some bacteria, such as Bacillus subtilis, an additional enzyme, EC 5.3.99.10 converts that compound into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, and that it is the latter that serves as the substrate for the synthase.
  • In addition to this activity, the enzyme participates in a salvage pathway, acting on 4-methyl-5-(2-phosphono-oxyethyl)thiazole, which is produced from thiamine degradation products.
  • In yeast this activity is found in a bifunctional enzyme and in the plant Arabidopsis thaliana the activity is part of a trifunctional enzyme.
Cross-references
BRENDA2.5.1.3
EC2PDB2.5.1.3
ExplorEnz2.5.1.3
PRIAM enzyme-specific profiles2.5.1.3
KEGG Ligand Database for Enzyme Nomenclature2.5.1.3
IUBMB Enzyme Nomenclature2.5.1.3
IntEnz2.5.1.3
MEDLINEFind literature relating to 2.5.1.3
MetaCyc2.5.1.3
Rhea expert-curated reactions2.5.1.3
UniProtKB/Swiss-Prot
P40386, THI6_SCHPOP41835, THI6_YEASTQ57688, THIDN_METJA
Q9WZP7, THIDN_THEMAO66833, THIE1_AQUAEQ97RS5, THIE1_STRPN
Q8DQK4, THIE1_STRR6O67378, THIE2_AQUAEP66920, THIE2_STRPN
P66921, THIE2_STRR6Q8G7X1, THIEC_BIFLOQ8FTH8, THIED_COREF
Q8NQH1, THIED_CORGLP61422, THIED_GEOSLA0LTK3, THIE_ACIC1
B7JBI2, THIE_ACIF2B5ERP0, THIE_ACIF5B3GX82, THIE_ACTP7
A6VPG9, THIE_ACTSZQ8UAS8, THIE_AGRFCQ21VL5, THIE_ALBFT
Q0VSP5, THIE_ALCBSQ5WH87, THIE_ALKCKA6TMN5, THIE_ALKMQ
A8MK92, THIE_ALKOOQ2IM25, THIE_ANADEB7GKQ8, THIE_ANOFW
O28205, THIE_ARCFUQ5P6J5, THIE_AROAEA0JYP1, THIE_ARTS2
A8IGE6, THIE_AZOC5A1KB60, THIE_AZOSBC1DMY6, THIE_AZOVD
C3PBW1, THIE_BACAAC3L627, THIE_BACACA0R981, THIE_BACAH
Q81Z95, THIE_BACANB7JN72, THIE_BACC0P61410, THIE_BACC1
C1EVE6, THIE_BACC3B7H7H5, THIE_BACC4B7HT70, THIE_BACC7
A7GKR4, THIE_BACCNB9J2L5, THIE_BACCQQ81IG8, THIE_BACCR
Q63GK3, THIE_BACCZQ5LCA7, THIE_BACFNQ64TA1, THIE_BACFR
Q6HP17, THIE_BACHKQ65DK0, THIE_BACLDA9VRN4, THIE_BACMK
A8FIR6, THIE_BACP2P39594, THIE_BACSUQ8AA13, THIE_BACTN
A7ZA58, THIE_BACVZQ2KUS6, THIE_BORA1Q7WF72, THIE_BORBR
Q7W3U2, THIE_BORPAQ7W049, THIE_BORPEB9MN52, THIE_CALBD
A8M9N4, THIE_CALMQQ8R806, THIE_CALS4A4XG66, THIE_CALS8
A8FMD4, THIE_CAMJ8Q9PNL3, THIE_CAMJEA1W068, THIE_CAMJJ
Q5HU23, THIE_CAMJRB0SUK3, THIE_CAUSKA9WDL8, THIE_CHLAA
Q5L6R5, THIE_CHLABQ824E9, THIE_CHLCVB3ED41, THIE_CHLL2
Q3B4B1, THIE_CHLL3B3QNM2, THIE_CHLP8A1BGM7, THIE_CHLPD
A4SEP8, THIE_CHLPMQ8KD79, THIE_CHLTEQ7P1R3, THIE_CHRVO
A8AKT0, THIE_CITK8Q97LQ9, THIE_CLOABA7FPT0, THIE_CLOB1
C3L061, THIE_CLOB6A6M1W6, THIE_CLOB8B2UY65, THIE_CLOBA
B2TQ13, THIE_CLOBBA5HYZ3, THIE_CLOBHC1FSC1, THIE_CLOBJ
B1IEG6, THIE_CLOBKA7GAL0, THIE_CLOBLB1KV12, THIE_CLOBM
Q186F8, THIE_CLOD6A0Q2A0, THIE_CLONNQ0TQV4, THIE_CLOP1
Q8XKQ8, THIE_CLOPEQ0STA1, THIE_CLOPSQ893R0, THIE_CLOTE
B5Y6I1, THIE_COPPDQ8FP55, THIE_COREFQ4JVZ1, THIE_CORJK
A7MJ80, THIE_CROS8Q478V2, THIE_DECARQ1IX16, THIE_DEIGD
Q9RYX9, THIE_DEIRAB8FUD4, THIE_DESHDQ24XQ0, THIE_DESHY
B5YA97, THIE_DICT6B8E358, THIE_DICTDA7ZUK8, THIE_ECO24
Q8X6Y0, THIE_ECO57B5Z089, THIE_ECO5EA8A793, THIE_ECOHS
A1AIG4, THIE_ECOK1Q0TA72, THIE_ECOL5Q8FB78, THIE_ECOL6
B1IUQ4, THIE_ECOLCP30137, THIE_ECOLIB6I5K4, THIE_ECOSE
Q1R5V9, THIE_ECOUTA4W5B6, THIE_ENT38Q830K5, THIE_ENTFA
Q2NB00, THIE_ERYLHA5FJJ1, THIE_FLAJ1A6GWR9, THIE_FLAPJ
Q8RI59, THIE_FUSNNQ5KZU0, THIE_GEOKAP61411, THIE_GEOSL
A4IN28, THIE_GEOTNQ7NNK8, THIE_GLOVIQ4QNC6, THIE_HAEI8
A5UA71, THIE_HAEIEA5UGT0, THIE_HAEIGP71350, THIE_HAEIN
Q9KCY8, THIE_HALH5A1WYL4, THIE_HALHLQ5V0G6, THIE_HALMA
Q18GX9, THIE_HALWDQ1CT27, THIE_HELPHQ9ZL01, THIE_HELPJ
B2USY5, THIE_HELPSO25514, THIE_HELPYA9AZD9, THIE_HERA2
Q0I131, THIE_HISS1B4U6B2, THIE_HYDS0Q0BXD3, THIE_HYPNA
A6SUR1, THIE_JANMAA6W6A2, THIE_KINRDA6TGQ0, THIE_KLEP7
Q1ILG3, THIE_KORVEB3W783, THIE_LACCBQ9CG48, THIE_LACLA
A2RKJ7, THIE_LACLMQ02YS6, THIE_LACLSQ03CB2, THIE_LACP3
Q890C0, THIE_LACPLC1DCM3, THIE_LARHHQ38ZM1, THIE_LATSS
Q1MRJ6, THIE_LAWIPB0SE83, THIE_LEPBAB0SMR9, THIE_LEPBP
B1MX63, THIE_LEUCKQ03NS1, THIE_LEVBAB2GBV5, THIE_LIMF3
A5VKA1, THIE_LIMRDB2G7Q4, THIE_LIMRJQ92EW5, THIE_LISIN
C1KZ34, THIE_LISMCQ723Y9, THIE_LISMFB8DET0, THIE_LISMH
Q8YA44, THIE_LISMOA0AFC5, THIE_LISW6B1HX34, THIE_LYSSC
Q65US7, THIE_MANSMA1TYG6, THIE_MARN8Q8TMD6, THIE_METAC
Q0W1L8, THIE_METARA7IA09, THIE_METB6Q466J5, THIE_METBF
Q602R3, THIE_METCAQ1GXW1, THIE_METFKQ2FM63, THIE_METHJ
A4FX32, THIE_METM5A9AAG9, THIE_METM6A6VG83, THIE_METM7
Q8PS49, THIE_METMAA3CS45, THIE_METMJP61413, THIE_METMP
A5ULP4, THIE_METS3A6UPE6, THIE_METVSQ2RGI8, THIE_MOOTA
A0QLT6, THIE_MYCA1P66917, THIE_MYCBOA1KFN6, THIE_MYCBP
A4T2R5, THIE_MYCGIB8ZU95, THIE_MYCLBQ9ZBL5, THIE_MYCLE
B2HPZ9, THIE_MYCMMP61412, THIE_MYCPAA0QQK7, THIE_MYCS2
A3PTW9, THIE_MYCSJA1UAB4, THIE_MYCSKQ1BEL9, THIE_MYCSS
A5TZE0, THIE_MYCTAP9WG74, THIE_MYCTOP9WG75, THIE_MYCTU
A0PRY2, THIE_MYCUAA1T2Z5, THIE_MYCVPQ1D282, THIE_MYXXD
Q3IP34, THIE_NATPDQ5F5C2, THIE_NEIG1Q9JWI2, THIE_NEIMA
Q9JXF7, THIE_NEIMBQ0AFV0, THIE_NITECQ82UQ7, THIE_NITEU
Q2Y5Q6, THIE_NITMUQ3JDH3, THIE_NITOCQ5YNP9, THIE_NOCFA
B2J6F7, THIE_NOSP7Q8YX72, THIE_NOSS1Q8ESZ3, THIE_OCEIH
Q7U5U1, THIE_PARMWP57930, THIE_PASMUQ6DAM1, THIE_PECAS
Q03GM4, THIE_PEDPAA5D4K4, THIE_PELTSQ4FN35, THIE_PELUB
C0QR82, THIE_PERMHQ7N964, THIE_PHOLLA6L645, THIE_PHOV8
Q6KZH9, THIE_PICTOA2CB21, THIE_PROM3Q7VAV5, THIE_PROMA
B4EYU2, THIE_PROMHQ7V8I3, THIE_PROMMQ7V0I3, THIE_PROMP
A2BSJ5, THIE_PROMSQ48DP2, THIE_PSE14A6V0D3, THIE_PSEA7
B7V9E0, THIE_PSEA8Q02SE4, THIE_PSEABQ9HX40, THIE_PSEAE
Q1I4H6, THIE_PSEE4Q4K5I7, THIE_PSEF5C3K2K2, THIE_PSEFS
A4XYV5, THIE_PSEMYA5W9G9, THIE_PSEP1Q3K6C1, THIE_PSEPF
B0KJV8, THIE_PSEPGQ88DP1, THIE_PSEPKB1J1Y7, THIE_PSEPW
Q87VY6, THIE_PSESMQ4ZNA1, THIE_PSEU2A5WDP0, THIE_PSYWF
Q9UZQ5, THIE_PYRABQ8U192, THIE_PYRFUO58878, THIE_PYRHO
O34294, THIE_RHIECQ7UQH1, THIE_RHOBAB6INN5, THIE_RHOCS
A7NRF7, THIE_ROSCSA5UUL3, THIE_ROSS1B8I3J4, THIE_RUMCH
Q21MI9, THIE_SACD2A4F727, THIE_SACENB5F1H6, THIE_SALA4
A8M4E6, THIE_SALAIA9MHD7, THIE_SALARQ57H62, THIE_SALCH
B5FQK8, THIE_SALDCB5QYE8, THIE_SALEPB5RFJ1, THIE_SALG2
B4TCT2, THIE_SALHSB4T0Z5, THIE_SALNSQ5PKA7, THIE_SALPA
A9N0K5, THIE_SALPBB5BJR2, THIE_SALPKQ2S2A8, THIE_SALRD
B4TQK3, THIE_SALSVQ8Z325, THIE_SALTIA4XBL2, THIE_SALTO
Q9L9I8, THIE_SALTYA8G8F3, THIE_SERP5B2TWI0, THIE_SHIB3
Q31U04, THIE_SHIBSQ32AG6, THIE_SHIDSQ0SY07, THIE_SHIF8
Q83PB9, THIE_SHIFLQ3YUZ1, THIE_SHISSC4XIJ2, THIE_SOLM1
A7X4S8, THIE_STAA1A6U3H7, THIE_STAA2Q2FF35, THIE_STAA3
Q2FWG3, THIE_STAA8A5IUN7, THIE_STAA9Q2YUL2, THIE_STAAB
Q5HEA8, THIE_STAACA6QIT5, THIE_STAAEP66918, THIE_STAAM
P66919, THIE_STAANQ6GEY4, THIE_STAARQ6G7L9, THIE_STAAS
Q8NVH5, THIE_STAAWQ9RGS5, THIE_STACTQ5HMD0, THIE_STAEQ
Q8CNK2, THIE_STAESQ4L7X3, THIE_STAHJQ49Z39, THIE_STAS1
Q3K1L6, THIE_STRA1Q8E5W9, THIE_STRA3Q8E092, THIE_STRA5
Q82AF9, THIE_STRAWQ9S2V2, THIE_STRCOA4W0K4, THIE_STRS2
A4VQX9, THIE_STUS1A5GMH7, THIE_SYNPWQ0IC17, THIE_SYNS3
Q3AL68, THIE_SYNSCQ0AZ86, THIE_SYNWWP72965, THIE_SYNY3
Q9HIQ4, THIE_THEACQ47R33, THIE_THEFYQ72KL8, THIE_THET2
Q5SKG9, THIE_THET8Q8DHK2, THIE_THEVBQ97BE8, THIE_THEVO
Q3SFU7, THIE_THIDAB8GLE3, THIE_THISHA7N7S3, THIE_VIBC1
Q87JW8, THIE_VIBPAQ7M9N9, THIE_WOLSUQ8PH45, THIE_XANAC
Q4UYA4, THIE_XANC8Q8P5R7, THIE_XANCPA7IGG9, THIE_XANP2
Q9PGC4, THIE_XYLFAQ87AX6, THIE_XYLFTA7FNH7, THIE_YERP3
Q1C1U8, THIE_YERPAQ8ZAQ1, THIE_YERPEQ1CN71, THIE_YERPN
A4TS25, THIE_YERPPQ66FP6, THIE_YERPSQ67T51, THIME_SYMTH
O26949, THIN_METTHQ5M731, TPS1L_ARATHO48881, TPS1_BRANA
Q2QWK9, TPS1_ORYSJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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