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ENZYME entry: EC 2.5.1.46

Accepted Name
Deoxyhypusine synthase.
Alternative Name(s)
(4-aminobutyl)lysine synthase.
[eIF-5A]-deoxyhypusine synthase.
Spermidine dehydrogenase.
Reaction catalysed
[eIF5A-precursor]-lysine + spermidine <=> [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
Cofactor(s)
NAD(+).
Comment(s)
  • The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity.
  • Catalyzes the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor.
  • The reaction occurs in four steps: NAD(+)-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d).
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor.
  • Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29.
  • Formerly EC 1.1.1.249.
Cross-references
BRENDA2.5.1.46
EC2PDB2.5.1.46
ExplorEnz2.5.1.46
PRIAM enzyme-specific profiles2.5.1.46
KEGG Ligand Database for Enzyme Nomenclature2.5.1.46
IUBMB Enzyme Nomenclature2.5.1.46
IntEnz2.5.1.46
MEDLINEFind literature relating to 2.5.1.46
MetaCyc2.5.1.46
Rhea expert-curated reactions2.5.1.46
UniProtKB/Swiss-Prot
O28088, DHYS1_ARCFU;  Q8TS38, DHYS1_METAC;  Q8PV89, DHYS1_METMA;  
O27984, DHYS2_ARCFU;  Q8TLM3, DHYS2_METAC;  Q8Q051, DHYS2_METMA;  
Q38BX0, DHYSC_TRYB2;  Q9YE72, DHYS_AERPE;  Q9FI94, DHYS_ARATH;  
Q75EW4, DHYS_ASHGO;  Q6EWQ6, DHYS_BOVIN;  Q6RJS2, DHYS_BRANA;  
Q9XXJ0, DHYS_CAEEL;  Q6FRN2, DHYS_CANGA;  Q6BJH5, DHYS_DEBHA;  
Q9AXQ8, DHYS_DIACA;  Q54MQ7, DHYS_DICDI;  Q9VSF4, DHYS_DROME;  
Q8SQN2, DHYS_ENCCU;  B0R5L2, DHYS_HALS3;  Q9HPX2, DHYS_HALSA;  
P49366, DHYS_HUMAN;  A8AA61, DHYS_IGNH4;  Q6CNG7, DHYS_KLULA;  
B5APK2, DHYS_LEIDO;  Q58224, DHYS_METJA;  Q8TXD7, DHYS_METKA;  
A4YHK6, DHYS_METS5;  Q977X6, DHYS_METTE;  O26230, DHYS_METTH;  
A6URC0, DHYS_METVS;  Q3TXU5, DHYS_MOUSE;  Q9AXQ9, DHYS_MUSAC;  
P49365, DHYS_NEUCR;  Q6KZL5, DHYS_PICTO;  Q9V0N5, DHYS_PYRAB;  
Q8ZT09, DHYS_PYRAE;  A3MVC9, DHYS_PYRCJ;  Q8U407, DHYS_PYRFU;  
O50105, DHYS_PYRHO;  Q6AY53, DHYS_RAT;  Q97ZF1, DHYS_SACS2;  
O94337, DHYS_SCHPO;  Q9SC14, DHYS_SENVE;  Q9AXR0, DHYS_SOLLC;  
Q4J978, DHYS_SULAC;  C3N5B4, DHYS_SULIA;  C4KGY0, DHYS_SULIK;  
C3MPN8, DHYS_SULIL;  C3MYN2, DHYS_SULIM;  C3NHT5, DHYS_SULIN;  
C3NDW8, DHYS_SULIY;  Q971T3, DHYS_SULTO;  Q9HL74, DHYS_THEAC;  
C5A5L0, DHYS_THEGJ;  Q5JEY0, DHYS_THEKO;  B6YVB1, DHYS_THEON;  
Q97BN6, DHYS_THEVO;  Q9SC80, DHYS_TOBAC;  Q6CG56, DHYS_YARLI;  
P38791, DHYS_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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