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ENZYME entry: EC 2.5.1.46

Accepted Name
deoxyhypusine synthase
Alternative Name(s)
(4-aminobutyl)lysine synthase
[eIF-5A]-deoxyhypusine synthase
spermidine dehydrogenase
Reaction catalysed
[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
Comment(s)
  • The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity.
  • Catalyzes the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor.
  • The reaction occurs in four steps: NAD(+)-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d).
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor.
  • Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29.
  • Formerly EC 1.1.1.249.
Cross-references
BRENDA2.5.1.46
EC2PDB2.5.1.46
ExplorEnz2.5.1.46
PRIAM enzyme-specific profiles2.5.1.46
KEGG Ligand Database for Enzyme Nomenclature2.5.1.46
IUBMB Enzyme Nomenclature2.5.1.46
IntEnz2.5.1.46
MEDLINEFind literature relating to 2.5.1.46
MetaCyc2.5.1.46
Rhea expert-curated reactions2.5.1.46
UniProtKB/Swiss-Prot
O28088, DHYS1_ARCFUQ8TS38, DHYS1_METACQ8PV89, DHYS1_METMA
O27984, DHYS2_ARCFUQ8TLM3, DHYS2_METACQ8Q051, DHYS2_METMA
Q38BX0, DHYSC_TRYB2Q9YE72, DHYS_AERPEQ9FI94, DHYS_ARATH
Q6EWQ6, DHYS_BOVINQ6RJS2, DHYS_BRANAQ9XXJ0, DHYS_CAEEL
Q6FRN2, DHYS_CANGAQ6BJH5, DHYS_DEBHAQ9AXQ8, DHYS_DIACA
Q54MQ7, DHYS_DICDIQ9VSF4, DHYS_DROMEQ8SQN2, DHYS_ENCCU
Q75EW4, DHYS_EREGSB0R5L2, DHYS_HALS3Q9HPX2, DHYS_HALSA
P49366, DHYS_HUMANA8AA61, DHYS_IGNH4Q6CNG7, DHYS_KLULA
B5APK2, DHYS_LEIDOQ58224, DHYS_METJAQ8TXD7, DHYS_METKA
A4YHK6, DHYS_METS5Q977X6, DHYS_METTEO26230, DHYS_METTH
A6URC0, DHYS_METVSQ3TXU5, DHYS_MOUSEQ9AXQ9, DHYS_MUSAC
P49365, DHYS_NEUCRQ6KZL5, DHYS_PICTOQ9V0N5, DHYS_PYRAB
Q8ZT09, DHYS_PYRAEA3MVC9, DHYS_PYRCJQ8U407, DHYS_PYRFU
O50105, DHYS_PYRHOQ6AY53, DHYS_RATQ97ZF1, DHYS_SACS2
O94337, DHYS_SCHPOQ9SC14, DHYS_SENVEQ9AXR0, DHYS_SOLLC
Q4J978, DHYS_SULACC3N5B4, DHYS_SULIAC4KGY0, DHYS_SULIK
C3MPN8, DHYS_SULILC3MYN2, DHYS_SULIMC3NHT5, DHYS_SULIN
C3NDW8, DHYS_SULIYQ971T3, DHYS_SULTOQ9HL74, DHYS_THEAC
C5A5L0, DHYS_THEGJQ5JEY0, DHYS_THEKOB6YVB1, DHYS_THEON
Q97BN6, DHYS_THEVOQ9SC80, DHYS_TOBACQ6CG56, DHYS_YARLI
P38791, DHYS_YEAST

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