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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.5.1.49

Accepted Name
O-acetylhomoserine aminocarboxypropyltransferase.
Alternative Name(s)
Methionine synthase.
O-acetyl-L-homoserine acetate-lyase (adding methanethiol).
O-acetyl-L-homoserine sulfhydrolase.
O-acetylhomoserine (thiol)-lyase.
O-acetylhomoserine sulfhydrolase.
OAH sulfhydrylase.
Reaction catalysed
O-acetyl-L-homoserine + methanethiol <=> L-methionine + acetate
Comment(s)
  • Also reacts with other thiols and H(2)S, producing homocysteine or thioethers.
  • The name methionine synthase is more commonly applied to EC 2.1.1.13.
  • The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly.
  • Formerly EC 4.2.99.10.
Cross-references
PROSITEPDOC00677
BRENDA2.5.1.49
EC2PDB2.5.1.49
ExplorEnz2.5.1.49
PRIAM enzyme-specific profiles2.5.1.49
KEGG Ligand Database for Enzyme Nomenclature2.5.1.49
IUBMB Enzyme Nomenclature2.5.1.49
IntEnz2.5.1.49
MEDLINEFind literature relating to 2.5.1.49
MetaCyc2.5.1.49
UniProtKB/Swiss-Prot
P50125, CYSD_EMENI;  Q92441, CYSD_KLULA;  O13326, CYSD_SCHPO;  
P06106, CYSD_YEAST;  Q79VI4, METY_CORGL;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-