Expasy logo

ENZYME

ENZYME entry: EC 2.5.1.49

Accepted Name
O-acetylhomoserine aminocarboxypropyltransferase
Alternative Name(s)
methionine synthase
O-acetylhomoserine (thiol)-lyase
O-acetylhomoserine sulfhydrolase
O-acetyl-L-homoserine acetate-lyase (adding methanethiol)
O-acetyl-L-homoserine sulfhydrolase
OAH sulfhydrylase
Reaction catalysed
methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine
Comment(s)
  • Also reacts with other thiols and H2S, producing homocysteine or thioethers.
  • The name methionine synthase is more commonly applied to EC 2.1.1.13.
  • The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly.
  • Formerly EC 4.2.99.10.
Cross-references
BRENDA2.5.1.49
EC2PDB2.5.1.49
ExplorEnz2.5.1.49
PRIAM enzyme-specific profiles2.5.1.49
KEGG Ligand Database for Enzyme Nomenclature2.5.1.49
IUBMB Enzyme Nomenclature2.5.1.49
IntEnz2.5.1.49
MEDLINEFind literature relating to 2.5.1.49
MetaCyc2.5.1.49
Rhea expert-curated reactions2.5.1.49
UniProtKB/Swiss-Prot
P50125, CYSD_EMENIQ92441, CYSD_KLULAO13326, CYSD_SCHPO
P06106, CYSD_YEASTQ12198, METW_YEASTQ79VI4, METY_CORGL

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-