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ENZYME

ENZYME entry: EC 2.5.1.49

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.49
Accepted Name
O-acetylhomoserine aminocarboxypropyltransferase
Alternative Name(s)
methionine synthase
O-acetylhomoserine (thiol)-lyase
O-acetylhomoserine sulfhydrolase
O-acetyl-L-homoserine acetate-lyase (adding methanethiol)
O-acetyl-L-homoserine sulfhydrolase
OAH sulfhydrylase
Reaction catalysed
O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)
Comment(s)
  • Also reacts with other thiols and H2S, producing homocysteine or thioethers.
  • The name methionine synthase is more commonly applied to EC 2.1.1.13.
  • The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly.
  • Formerly EC 4.2.99.10.
Cross-references
BRENDA2.5.1.49
EC2PDB2.5.1.49
ExplorEnz2.5.1.49
KEGG Ligand Database for Enzyme Nomenclature2.5.1.49
IUBMB Enzyme Nomenclature2.5.1.49
MEDLINEFind literature relating to 2.5.1.49
MetaCyc2.5.1.49
Rhea expert-curated reactions2.5.1.49
UniProtKB/Swiss-Prot
P50125, CYSD_EMENIQ92441, CYSD_KLULAO13326, CYSD_SCHPO
P06106, CYSD_YEASTQ12198, METW_YEASTQ79VI4, METY_CORGL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-