A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.5.1.60
| Accepted Name |
|---|
| Protein geranylgeranyltransferase type II.
|
| Alternative Name(s) |
|---|
| GGTaseII. |
| Rab geranylgeranyltransferase. |
| RabGGTase. |
| Type II protein geranyl-geranyltransferase. |
| Reaction catalysed |
|---|
| Geranylgeranyl diphosphate + protein-cysteine <=> S-geranylgeranyl-protein + diphosphate |
| Comment(s) |
|---|
- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the
protein prenyltransferase family of enzymes.
- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-
related GTPases of a single family, the Rab family (Ypt/Sec4 in lower
eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
- Reaction is entirely dependent on the Rab substrate being bound to
Rab escort protein (REP).
- Post-translational modification with the geranylgeranyl moiety is
essential for Rab GTPases to be able to control the processes of
membrane docking and fusion.
|
| Cross-references |
|---|
| PROSITE | PDOC00703 |
| BRENDA | 2.5.1.60 |
| EC2PDB | 2.5.1.60 |
| ExplorEnz | 2.5.1.60 |
| PRIAM enzyme-specific profiles | 2.5.1.60 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.60 |
| IUBMB Enzyme Nomenclature | 2.5.1.60 |
| IntEnz | 2.5.1.60 |
| MEDLINE | Find literature relating to 2.5.1.60 |
| MetaCyc | 2.5.1.60 |
| UniProtKB/Swiss-Prot |
| P41992, GGTB2_CAEEL; | Q8VYB7, PGTA1_ARATH; | Q9FJ32, PGTA2_ARATH; |
| Q5EA80, PGTA_BOVIN; | O93829, PGTA_CANAX; | Q55DQ4, PGTA_DICDI; |
| Q92696, PGTA_HUMAN; | Q9JHK4, PGTA_MOUSE; | A5A779, PGTA_PIG; |
| Q5NVK5, PGTA_PONAB; | Q08602, PGTA_RAT; | O94412, PGTA_SCHPO; |
| Q00618, PGTA_YEAST; | Q84J75, PGTB1_ARATH; | Q9LHL5, PGTB2_ARATH; |
| Q5E9B3, PGTB2_BOVIN; | O93830, PGTB2_CANAX; | B0G172, PGTB2_DICDI; |
| P53611, PGTB2_HUMAN; | P53612, PGTB2_MOUSE; | Q08603, PGTB2_RAT; |
| P46960, PGTB2_SCHPO; | P20133, PGTB2_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-