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ENZYME

ENZYME entry: EC 2.5.1.60

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.60
Accepted Name
protein geranylgeranyltransferase type II
Alternative Name(s)
GGTaseII
Rab geranylgeranyltransferase
RabGGTase
type II protein geranyl-geranyltransferase
Reaction catalysed
geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate
Comment(s)
  • This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes.
  • Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
  • Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP).
  • Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
Cross-references
BRENDA2.5.1.60
EC2PDB2.5.1.60
ExplorEnz2.5.1.60
KEGG Ligand Database for Enzyme Nomenclature2.5.1.60
IUBMB Enzyme Nomenclature2.5.1.60
MEDLINEFind literature relating to 2.5.1.60
MetaCyc2.5.1.60
Rhea expert-curated reactions2.5.1.60
UniProtKB/Swiss-Prot
P41992, GGTB2_CAEELQ84J75, PG2B1_ARATHQ8VYB7, PGTA1_ARATH
Q9FJ32, PGTA2_ARATHQ5EA80, PGTA_BOVINO93829, PGTA_CANAX
Q55DQ4, PGTA_DICDIQ92696, PGTA_HUMANQ9JHK4, PGTA_MOUSE
A5A779, PGTA_PIGQ5NVK5, PGTA_PONABQ08602, PGTA_RAT
O94412, PGTA_SCHPOQ00618, PGTA_YEASTQ9LHL5, PGTB2_ARATH
Q5E9B3, PGTB2_BOVINO93830, PGTB2_CANAXB0G172, PGTB2_DICDI
P53611, PGTB2_HUMANP53612, PGTB2_MOUSEQ08603, PGTB2_RAT
P46960, PGTB2_SCHPOP20133, PGTB2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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