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ENZYME entry: EC 2.5.1.60

Accepted Name
protein geranylgeranyltransferase type II.
Alternative Name(s)
GGTaseII.
Rab geranylgeranyltransferase.
RabGGTase.
type II protein geranyl-geranyltransferase.
Reaction catalysed
geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]
Comment(s)
  • This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes.
  • Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
  • Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP).
  • Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
Cross-references
BRENDA2.5.1.60
EC2PDB2.5.1.60
ExplorEnz2.5.1.60
PRIAM enzyme-specific profiles2.5.1.60
KEGG Ligand Database for Enzyme Nomenclature2.5.1.60
IUBMB Enzyme Nomenclature2.5.1.60
IntEnz2.5.1.60
MEDLINEFind literature relating to 2.5.1.60
MetaCyc2.5.1.60
Rhea expert-curated reactions2.5.1.60
UniProtKB/Swiss-Prot
P41992, GGTB2_CAEEL;  Q84J75, PG2B1_ARATH;  Q8VYB7, PGTA1_ARATH;  
Q9FJ32, PGTA2_ARATH;  Q5EA80, PGTA_BOVIN;  O93829, PGTA_CANAX;  
Q55DQ4, PGTA_DICDI;  Q92696, PGTA_HUMAN;  Q9JHK4, PGTA_MOUSE;  
A5A779, PGTA_PIG;  Q5NVK5, PGTA_PONAB;  Q08602, PGTA_RAT;  
O94412, PGTA_SCHPO;  Q00618, PGTA_YEAST;  Q9LHL5, PGTB2_ARATH;  
Q5E9B3, PGTB2_BOVIN;  O93830, PGTB2_CANAX;  B0G172, PGTB2_DICDI;  
P53611, PGTB2_HUMAN;  P53612, PGTB2_MOUSE;  Q08603, PGTB2_RAT;  
P46960, PGTB2_SCHPO;  P20133, PGTB2_YEAST;  

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