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ENZYME entry: EC 2.5.1.60
Accepted Name |
protein geranylgeranyltransferase type II.
|
Alternative Name(s) |
GGTaseII. |
Rab geranylgeranyltransferase. |
RabGGTase. |
type II protein geranyl-geranyltransferase. |
Reaction catalysed |
geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] |
Comment(s) |
- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the
protein prenyltransferase family of enzymes.
- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-
related GTPases of a single family, the Rab family (Ypt/Sec4 in lower
eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
- Reaction is entirely dependent on the Rab substrate being bound to
Rab escort protein (REP).
- Post-translational modification with the geranylgeranyl moiety is
essential for Rab GTPases to be able to control the processes of
membrane docking and fusion.
|
Cross-references |
BRENDA | 2.5.1.60 |
EC2PDB | 2.5.1.60 |
ExplorEnz | 2.5.1.60 |
PRIAM enzyme-specific profiles | 2.5.1.60 |
KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.60 |
IUBMB Enzyme Nomenclature | 2.5.1.60 |
IntEnz | 2.5.1.60 |
MEDLINE | Find literature relating to 2.5.1.60 |
MetaCyc | 2.5.1.60 |
Rhea expert-curated reactions | 2.5.1.60 |
UniProtKB/Swiss-Prot |
P41992, GGTB2_CAEEL; | Q84J75, PG2B1_ARATH; | Q8VYB7, PGTA1_ARATH; |
Q9FJ32, PGTA2_ARATH; | Q5EA80, PGTA_BOVIN; | O93829, PGTA_CANAX; |
Q55DQ4, PGTA_DICDI; | Q92696, PGTA_HUMAN; | Q9JHK4, PGTA_MOUSE; |
A5A779, PGTA_PIG; | Q5NVK5, PGTA_PONAB; | Q08602, PGTA_RAT; |
O94412, PGTA_SCHPO; | Q00618, PGTA_YEAST; | Q9LHL5, PGTB2_ARATH; |
Q5E9B3, PGTB2_BOVIN; | O93830, PGTB2_CANAX; | B0G172, PGTB2_DICDI; |
P53611, PGTB2_HUMAN; | P53612, PGTB2_MOUSE; | Q08603, PGTB2_RAT; |
P46960, PGTB2_SCHPO; | P20133, PGTB2_YEAST; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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