A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.5.1.59
| Accepted Name |
|---|
| Protein geranylgeranyltransferase type I.
|
| Alternative Name(s) |
|---|
| GGTase-I. |
| GGTaseI. |
| Type I protein geranyl-geranyltransferase. |
| Reaction catalysed |
|---|
| Geranylgeranyl diphosphate + protein-cysteine <=> S-geranylgeranyl-protein + diphosphate |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.60, constitutes the
protein prenyltransferase family of enzymes.
- Catalyzes the formation of a thioether linkage between the C-1 atom
of the geranylgeranyl group and a cysteine residue fourth from the
C-terminus of the protein.
- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
where the terminal residue, X, is preferably leucine; serine,
methionine, alanine or glutamine makes the protein a substrate for
EC 2.5.1.58.
- The enzymes are relaxed in specificity for A(1), but cannot act if
A(2) is aromatic.
- Known targets of this enzyme include most gamma-subunits of
heterotrimeric G proteins and Ras-related GTPases such as members of
the Ras and Rac/Rho families.
- The Zn(2+) is required for peptide, but not for isoprenoid, substrate
binding.
|
| Cross-references |
|---|
| PROSITE | PDOC00703 |
| BRENDA | 2.5.1.59 |
| EC2PDB | 2.5.1.59 |
| ExplorEnz | 2.5.1.59 |
| PRIAM enzyme-specific profiles | 2.5.1.59 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.59 |
| IUBMB Enzyme Nomenclature | 2.5.1.59 |
| IntEnz | 2.5.1.59 |
| MEDLINE | Find literature relating to 2.5.1.59 |
| MetaCyc | 2.5.1.59 |
| UniProtKB/Swiss-Prot |
| Q9LX33, FNTA_ARATH; | P29702, FNTA_BOVIN; | Q9Y765, FNTA_CANAX; |
| Q54RT9, FNTA_DICDI; | P49354, FNTA_HUMAN; | Q61239, FNTA_MOUSE; |
| O24304, FNTA_PEA; | Q04631, FNTA_RAT; | O60052, FNTA_SCHPO; |
| P93227, FNTA_SOLLC; | P29703, FNTA_YEAST; | O80642, PGT1_ARATH; |
| Q5EAD5, PGTB1_BOVIN; | Q55DA3, PGTB1_DICDI; | P53609, PGTB1_HUMAN; |
| Q8BUY9, PGTB1_MOUSE; | P53610, PGTB1_RAT; | P32434, PGTB1_SCHPO; |
| P18898, PGTB1_YEAST; |
|
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