ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.5.1.59

Accepted Name

Protein geranylgeranyltransferase type I.

Alternative Name(s)

GGTase-I.

GGTaseI.

Type I protein geranyl-geranyltransferase.

Reaction catalysed

Geranylgeranyl diphosphate + protein-cysteine <=> S-geranylgeranyl-protein + diphosphate

Cofactor(s)

Zn(2+).

Comment(s)

This enzyme, along with EC 2.5.1.58 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
Catalyzes the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein.
These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58.
The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
The Zn(2+) is required for peptide, but not for isoprenoid, substrate binding.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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