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ENZYME entry: EC 2.5.1.59

Accepted Name
Protein geranylgeranyltransferase type I.
Alternative Name(s)
GGTase-I.
GGTaseI.
Type I protein geranyl-geranyltransferase.
Reaction catalysed
Geranylgeranyl diphosphate + protein-cysteine <=> S-geranylgeranyl-protein + diphosphate
Cofactor(s)
Zn(2+).
Comment(s)
  • This enzyme, along with EC 2.5.1.58 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
  • Catalyzes the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein.
  • These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58.
  • The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
  • Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
  • The Zn(2+) is required for peptide, but not for isoprenoid, substrate binding.
Cross-references
PROSITEPDOC00703
BRENDA2.5.1.59
EC2PDB2.5.1.59
ExplorEnz2.5.1.59
PRIAM enzyme-specific profiles2.5.1.59
KEGG Ligand Database for Enzyme Nomenclature2.5.1.59
IUBMB Enzyme Nomenclature2.5.1.59
IntEnz2.5.1.59
MEDLINEFind literature relating to 2.5.1.59
MetaCyc2.5.1.59
Rhea expert-curated reactions2.5.1.59
UniProtKB/Swiss-Prot
Q9LX33, FNTA_ARATH;  P29702, FNTA_BOVIN;  Q9Y765, FNTA_CANAX;  
Q54RT9, FNTA_DICDI;  P49354, FNTA_HUMAN;  Q61239, FNTA_MOUSE;  
O24304, FNTA_PEA;  Q04631, FNTA_RAT;  O60052, FNTA_SCHPO;  
P93227, FNTA_SOLLC;  P29703, FNTA_YEAST;  O80642, PGTB1_ARATH;  
Q5EAD5, PGTB1_BOVIN;  Q55DA3, PGTB1_DICDI;  P53609, PGTB1_HUMAN;  
Q8BUY9, PGTB1_MOUSE;  P53610, PGTB1_RAT;  P32434, PGTB1_SCHPO;  
P18898, PGTB1_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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