ENZYME entry: EC 2.5.1.58
Accepted Name |
Protein farnesyltransferase.
|
Alternative Name(s) |
CAAX farnesyltransferase. |
FTase. |
Reaction catalysed |
Farnesyl diphosphate + protein-cysteine <=> S-farnesyl protein + diphosphate |
Cofactor(s) |
Mg(2+); Zn(2+).
|
Comment(s) |
- This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the
protein prenyltransferase family of enzymes.
- Catalyzes the formation of a thioether linkage between the C-1 of an
isoprenyl group and a cysteine residue fourth from the C-terminus of
the protein.
- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
where the terminal residue, X, is preferably serine, methionine,
alanine or glutamine; leucine makes the protein a substrate for
EC 2.5.1.59.
- The enzymes are relaxed in specificity for A(1), but cannot act if
A(2) is aromatic.
- Substrates of the prenyltransferases include Ras, Rho, Rab, other
Ras-related small GTP-binding proteins, gamma-subunits of
heterotrimeric G-proteins, nuclear lamins, centromeric proteins and
many proteins involved in visual signal transduction.
|
Cross-references |
PROSITE | PDOC00703 |
BRENDA | 2.5.1.58 |
EC2PDB | 2.5.1.58 |
ExplorEnz | 2.5.1.58 |
PRIAM enzyme-specific profiles | 2.5.1.58 |
KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.58 |
IUBMB Enzyme Nomenclature | 2.5.1.58 |
IntEnz | 2.5.1.58 |
MEDLINE | Find literature relating to 2.5.1.58 |
MetaCyc | 2.5.1.58 |
UniProtKB/Swiss-Prot |
Q9LX33, FNTA_ARATH; | P29702, FNTA_BOVIN; | Q9Y765, FNTA_CANAX; |
Q54RT9, FNTA_DICDI; | P49354, FNTA_HUMAN; | Q61239, FNTA_MOUSE; |
O24304, FNTA_PEA; | Q04631, FNTA_RAT; | O60052, FNTA_SCHPO; |
P93227, FNTA_SOLLC; | P29703, FNTA_YEAST; | Q38920, FNTB_ARATH; |
P49355, FNTB_BOVIN; | Q55D51, FNTB_DICDI; | P49356, FNTB_HUMAN; |
G4MY67, FNTB_MAGO7; | Q8K2I1, FNTB_MOUSE; | Q04903, FNTB_PEA; |
Q02293, FNTB_RAT; | O13782, FNTB_SCHPO; | P22007, FNTB_YEAST; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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