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ENZYME entry: EC 2.5.1.58

Accepted Name
Protein farnesyltransferase.
Alternative Name(s)
CAAX farnesyltransferase.
FTase.
Reaction catalysed
Farnesyl diphosphate + protein-cysteine <=> S-farnesyl protein + diphosphate
Cofactor(s)
Mg(2+); Zn(2+).
Comment(s)
  • This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
  • Catalyzes the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein.
  • These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59.
  • The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
  • Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction.
Cross-references
PROSITEPDOC00703
BRENDA2.5.1.58
EC2PDB2.5.1.58
ExplorEnz2.5.1.58
PRIAM enzyme-specific profiles2.5.1.58
KEGG Ligand Database for Enzyme Nomenclature2.5.1.58
IUBMB Enzyme Nomenclature2.5.1.58
IntEnz2.5.1.58
MEDLINEFind literature relating to 2.5.1.58
MetaCyc2.5.1.58
UniProtKB/Swiss-Prot
Q9LX33, FNTA_ARATH;  P29702, FNTA_BOVIN;  Q9Y765, FNTA_CANAX;  
Q54RT9, FNTA_DICDI;  P49354, FNTA_HUMAN;  Q61239, FNTA_MOUSE;  
O24304, FNTA_PEA;  Q04631, FNTA_RAT;  O60052, FNTA_SCHPO;  
P93227, FNTA_SOLLC;  P29703, FNTA_YEAST;  Q38920, FNTB_ARATH;  
P49355, FNTB_BOVIN;  Q55D51, FNTB_DICDI;  P49356, FNTB_HUMAN;  
Q8K2I1, FNTB_MOUSE;  Q04903, FNTB_PEA;  Q02293, FNTB_RAT;  
O13782, FNTB_SCHPO;  P22007, FNTB_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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