| Accepted Name |
|---|
| Protein farnesyltransferase.
|
| Alternative Name(s) |
|---|
| CAAX farnesyltransferase. |
| FTase. |
| Reaction catalysed |
|---|
| Farnesyl diphosphate + protein-cysteine <=> S-farnesyl protein + diphosphate |
| Cofactor(s) |
|---|
| Mg(2+); Zn(2+).
|
| Comment(s) |
|---|
- This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the
protein prenyltransferase family of enzymes.
- Catalyzes the formation of a thioether linkage between the C-1 of an
isoprenyl group and a cysteine residue fourth from the C-terminus of
the protein.
- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
where the terminal residue, X, is preferably serine, methionine,
alanine or glutamine; leucine makes the protein a substrate for
EC 2.5.1.59.
- The enzymes are relaxed in specificity for A(1), but cannot act if
A(2) is aromatic.
- Substrates of the prenyltransferases include Ras, Rho, Rab, other
Ras-related small GTP-binding proteins, gamma-subunits of
heterotrimeric G-proteins, nuclear lamins, centromeric proteins and
many proteins involved in visual signal transduction.
|
| Cross-references |
|---|
| PROSITE | PDOC00703 |
| BRENDA | 2.5.1.58 |
| EC2PDB | 2.5.1.58 |
| ExplorEnz | 2.5.1.58 |
| PRIAM enzyme-specific profiles | 2.5.1.58 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.58 |
| IUBMB Enzyme Nomenclature | 2.5.1.58 |
| IntEnz | 2.5.1.58 |
| MEDLINE | Find literature relating to 2.5.1.58 |
| MetaCyc | 2.5.1.58 |
| Rhea expert-curated reactions | 2.5.1.58 |
| UniProtKB/Swiss-Prot |
| Q9LX33, FNTA_ARATH; | P29702, FNTA_BOVIN; | Q9Y765, FNTA_CANAX; |
| Q54RT9, FNTA_DICDI; | P49354, FNTA_HUMAN; | Q61239, FNTA_MOUSE; |
| O24304, FNTA_PEA; | Q04631, FNTA_RAT; | O60052, FNTA_SCHPO; |
| P93227, FNTA_SOLLC; | P29703, FNTA_YEAST; | Q38920, FNTB_ARATH; |
| P49355, FNTB_BOVIN; | Q55D51, FNTB_DICDI; | P49356, FNTB_HUMAN; |
| G4MY67, FNTB_MAGO7; | Q8K2I1, FNTB_MOUSE; | Q04903, FNTB_PEA; |
| Q02293, FNTB_RAT; | O13782, FNTB_SCHPO; | P22007, FNTB_YEAST; |
|