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ENZYME

ENZYME entry: EC 2.5.1.58

Accepted Name
protein farnesyltransferase
Alternative Name(s)
CAAX farnesyltransferase
FTase
Reaction catalysed
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]
Comment(s)
  • This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
  • Catalyzes the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein.
  • These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59.
  • The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
  • Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction.
Cross-references
BRENDA2.5.1.58
EC2PDB2.5.1.58
ExplorEnz2.5.1.58
PRIAM enzyme-specific profiles2.5.1.58
KEGG Ligand Database for Enzyme Nomenclature2.5.1.58
IUBMB Enzyme Nomenclature2.5.1.58
IntEnz2.5.1.58
MEDLINEFind literature relating to 2.5.1.58
MetaCyc2.5.1.58
Rhea expert-curated reactions2.5.1.58
UniProtKB/Swiss-Prot
Q9LX33, FNTA_ARATHP29702, FNTA_BOVINQ9Y765, FNTA_CANAX
Q54RT9, FNTA_DICDIP49354, FNTA_HUMANQ61239, FNTA_MOUSE
O24304, FNTA_PEAQ04631, FNTA_RATO60052, FNTA_SCHPO
P93227, FNTA_SOLLCP29703, FNTA_YEASTQ38920, FNTB_ARATH
P49355, FNTB_BOVINQ55D51, FNTB_DICDIP49356, FNTB_HUMAN
G4MY67, FNTB_MAGO7Q8K2I1, FNTB_MOUSEQ04903, FNTB_PEA
Q02293, FNTB_RATO13782, FNTB_SCHPOP22007, FNTB_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-