| Accepted Name |
|---|
| protein farnesyltransferase
|
| Alternative Name(s) |
|---|
| CAAX farnesyltransferase |
| FTase |
| Reaction catalysed |
|---|
| L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate |
| Comment(s) |
|---|
- This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the
protein prenyltransferase family of enzymes.
- Catalyzes the formation of a thioether linkage between the C-1 of an
isoprenyl group and a cysteine residue fourth from the C-terminus of
the protein.
- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
where the terminal residue, X, is preferably serine, methionine,
alanine or glutamine; leucine makes the protein a substrate for
EC 2.5.1.59.
- The enzymes are relaxed in specificity for A(1), but cannot act if
A(2) is aromatic.
- Substrates of the prenyltransferases include Ras, Rho, Rab, other
Ras-related small GTP-binding proteins, gamma-subunits of
heterotrimeric G-proteins, nuclear lamins, centromeric proteins and
many proteins involved in visual signal transduction.
|
| Cross-references |
|---|
| Rhea expert-curated reactions | 2.5.1.58 |
| ExplorEnz | 2.5.1.58 |
| IUBMB Enzyme Nomenclature | 2.5.1.58 |
| UniProtKB/Swiss-Prot |
| Q9LX33, FNTA_ARATH | P29702, FNTA_BOVIN | Q9Y765, FNTA_CANAX |
| Q54RT9, FNTA_DICDI | P49354, FNTA_HUMAN | Q61239, FNTA_MOUSE |
| O24304, FNTA_PEA | Q04631, FNTA_RAT | O60052, FNTA_SCHPO |
| P93227, FNTA_SOLLC | P29703, FNTA_YEAST | Q38920, FNTB_ARATH |
| P49355, FNTB_BOVIN | Q55D51, FNTB_DICDI | P49356, FNTB_HUMAN |
| Q8K2I1, FNTB_MOUSE | Q04903, FNTB_PEA | G4MY67, FNTB_PYRO7 |
| Q02293, FNTB_RAT | O13782, FNTB_SCHPO | P22007, FNTB_YEAST |
|
| BRENDA | 2.5.1.58 |
| MetaCyc | 2.5.1.58 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.58 |
| EC2PDB | 2.5.1.58 |
| MEDLINE | Find literature relating to 2.5.1.58 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-
