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ENZYME

ENZYME entry: EC 2.6.1.121

PURL: https://purl.expasy.org/enzyme/EC/2.6.1.121
Accepted Name
8-amino-7-oxononanoate carboxylating dehydrogenase
Reaction catalysed
(8S)-8-amino-7-oxononanoate + L-lysyl-[protein] + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)
Comment(s)
  • The enzyme, which participates in biotin biosynthesis, is found in haloarchaea and some cyanobacteria.
  • It forms a conjugant between (7R,8S)-8-amino-7-oxononanoate and an internal lysine residue and catalyzes multiple reactions, including a reduction, a carboxylation of the epsilon-amino group of the lysine residue, and an oxidative cleavage of the conjugate to release (7R,8S)-8-amino-7-(carboxyamino)nonanoate.
  • During this process the lysine residue serves as an amino donor and is converted to (S)-2-amino-6-oxohexanoate, resulting in inactivation of the enzyme following a single turnover. cf. EC 2.6.1.105.
Cross-references
BRENDA2.6.1.121
EC2PDB2.6.1.121
ExplorEnz2.6.1.121
KEGG Ligand Database for Enzyme Nomenclature2.6.1.121
IUBMB Enzyme Nomenclature2.6.1.121
MEDLINEFind literature relating to 2.6.1.121
MetaCyc2.6.1.121
Rhea expert-curated reactions2.6.1.121
UniProtKB/Swiss-Prot
I3R9K3, BIOU_HALMTQ55650, BIOU_SYNY3

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