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ENZYME entry: EC 2.7.1.151

Accepted Name
inositol-polyphosphate multikinase.
Alternative Name(s)
inositol polyphosphate 6-/3-/5-kinase.
IP3/IP4 6-/3-kinase.
IP3/IP4 dual-specificity 6-/3-kinase.
IpK2.
Reaction catalysed
1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)
Comment(s)
  • This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.
  • The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively.
  • Yeast produces InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158.
Cross-references
BRENDA2.7.1.151
EC2PDB2.7.1.151
ExplorEnz2.7.1.151
PRIAM enzyme-specific profiles2.7.1.151
KEGG Ligand Database for Enzyme Nomenclature2.7.1.151
IUBMB Enzyme Nomenclature2.7.1.151
IntEnz2.7.1.151
MEDLINEFind literature relating to 2.7.1.151
MetaCyc2.7.1.151
Rhea expert-curated reactions2.7.1.151
UniProtKB/Swiss-Prot
A2X5H5, IPK2_ORYSI;  Q6H545, IPK2_ORYSJ;  Q9LY23, IPMKA_ARATH;  
Q9FLT2, IPMKB_ARATH;  Q8NFU5, IPMK_HUMAN;  Q7TT16, IPMK_MOUSE;  
Q99NI4, IPMK_RAT;  Q9US14, IPMK_SCHPO;  P07250, IPMK_YEAST;  

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