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ENZYME

ENZYME entry: EC 2.7.1.195

PURL: https://purl.expasy.org/enzyme/EC/2.7.1.195
Accepted Name
protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase
Alternative Name(s)
2-O-alpha-mannosyl-D-glycerate PTS permease
Reaction catalysed
(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.195
EC2PDB2.7.1.195
ExplorEnz2.7.1.195
KEGG Ligand Database for Enzyme Nomenclature2.7.1.195
IUBMB Enzyme Nomenclature2.7.1.195
MEDLINEFind literature relating to 2.7.1.195
MetaCyc2.7.1.195
Rhea expert-curated reactions2.7.1.195
UniProtKB/Swiss-Prot
P54745, MNGA_ECOLI

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