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ENZYME

ENZYME entry: EC 2.7.1.207

PURL: https://purl.expasy.org/enzyme/EC/2.7.1.207
Accepted Name
protein-N(pi)-phosphohistidine--lactose phosphotransferase
Alternative Name(s)
lactose PTS permease
Reaction catalysed
lactose(out) + N(pros)-phospho-L-histidyl-[protein] = lactose 6-phosphate(in) + L-histidyl-[protein]
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
BRENDA2.7.1.207
EC2PDB2.7.1.207
ExplorEnz2.7.1.207
KEGG Ligand Database for Enzyme Nomenclature2.7.1.207
IUBMB Enzyme Nomenclature2.7.1.207
MEDLINEFind literature relating to 2.7.1.207
MetaCyc2.7.1.207
Rhea expert-curated reactions2.7.1.207
UniProtKB/Swiss-Prot
P24400, PTLCB_LACCAP23531, PTLCB_LACLLQ5HE15, PTLCB_STAAC
Q931G6, PTLCB_STAAMQ99S77, PTLCB_STAANQ6GEN9, PTLCB_STAAR
Q6G7C4, PTLCB_STAASP11162, PTLCB_STAAUQ7A092, PTLCB_STAAW
Q5HM40, PTLCB_STAEQQ8CNF7, PTLCB_STAESQ4L869, PTLCB_STAHJ
P50976, PTLCB_STRMU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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