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ENZYME entry: EC 2.7.1.207

Accepted Name
Protein-N(pi)-phosphohistidine--lactose phosphotransferase.
Alternative Name(s)
Lactose PTS permease.
Reaction catalysed
[Protein]-N(pi)-phospho-L-histidine + lactose(Side 1) <=> [protein]-L-histidine + lactose 6'-phosphate(Side 2)
Comment(s)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
  • The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
  • The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
  • Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
  • The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
  • Formerly EC 2.7.1.69.
Cross-references
PROSITEPDOC00795
BRENDA2.7.1.207
EC2PDB2.7.1.207
ExplorEnz2.7.1.207
PRIAM enzyme-specific profiles2.7.1.207
KEGG Ligand Database for Enzyme Nomenclature2.7.1.207
IUBMB Enzyme Nomenclature2.7.1.207
IntEnz2.7.1.207
MEDLINEFind literature relating to 2.7.1.207
MetaCyc2.7.1.207
UniProtKB/Swiss-Prot
P24400, PTLCB_LACCA;  P23531, PTLCB_LACLL;  Q5HE15, PTLCB_STAAC;  
Q931G6, PTLCB_STAAM;  Q99S77, PTLCB_STAAN;  Q6GEN9, PTLCB_STAAR;  
Q6G7C4, PTLCB_STAAS;  P11162, PTLCB_STAAU;  Q7A092, PTLCB_STAAW;  
Q5HM40, PTLCB_STAEQ;  Q8CNF7, PTLCB_STAES;  Q4L869, PTLCB_STAHJ;  
P50976, PTLCB_STRMU;  

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