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ENZYME

ENZYME entry: EC 2.7.1.25

Accepted Name
adenylyl-sulfate kinase
Alternative Name(s)
adenosine 5'-phosphosulfate kinase
adenylylsulfate kinase
APS kinase
Reaction catalysed
adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)
Comment(s)
  • The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.
  • This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.
Cross-references
BRENDA2.7.1.25
EC2PDB2.7.1.25
ExplorEnz2.7.1.25
PRIAM enzyme-specific profiles2.7.1.25
KEGG Ligand Database for Enzyme Nomenclature2.7.1.25
IUBMB Enzyme Nomenclature2.7.1.25
IntEnz2.7.1.25
MEDLINEFind literature relating to 2.7.1.25
MetaCyc2.7.1.25
Rhea expert-curated reactions2.7.1.25
UniProtKB/Swiss-Prot
Q43295, APK1_ARATHO49196, APK2_ARATHQ9SRW7, APK3_ARATH
Q84JF0, APK4_ARATHO34577, CYSC1_BACSUQ9KCT0, CYSC1_HALH5
O06735, CYSC2_BACSUQ9K7H6, CYSC2_HALH5B0CAX3, CYSC_ACAM1
A0KP33, CYSC_AERHHQ9YCR6, CYSC_AERPEA4SRG6, CYSC_AERS4
O29953, CYSC_ARCFUQ5LES5, CYSC_BACFNQ64VR1, CYSC_BACFR
Q65JT8, CYSC_BACLDA8FD25, CYSC_BACP2Q8AAQ1, CYSC_BACTN
A7Z4I0, CYSC_BACVZP57497, CYSC_BUCAIQ8K9D4, CYSC_BUCAP
Q0BI00, CYSC_BURCMB9LKC1, CYSC_CHLSYA8ANW4, CYSC_CITK8
Q97MT8, CYSC_CLOABA5N960, CYSC_CLOK5A7MJ70, CYSC_CROS8
C1CVW7, CYSC_DEIDVQ1IYI1, CYSC_DEIGDP56861, CYSC_DEIRA
A7ZQJ4, CYSC_ECO24B7UHG9, CYSC_ECO27B7MKM4, CYSC_ECO45
B7LEG8, CYSC_ECO55P0A6J2, CYSC_ECO57B5Z3B2, CYSC_ECO5E
B7NT94, CYSC_ECO7IB7MYQ5, CYSC_ECO81B7LXG2, CYSC_ECO8A
C4ZZQ4, CYSC_ECOBWB1XCS6, CYSC_ECODHA8A3M9, CYSC_ECOHS
A1AEU4, CYSC_ECOK1Q0TEA8, CYSC_ECOL5Q8FEJ2, CYSC_ECOL6
B1IUS9, CYSC_ECOLCP0A6J1, CYSC_ECOLIB7N6Y0, CYSC_ECOLU
B6I6E0, CYSC_ECOSEB1LQ71, CYSC_ECOSMQ1R7U1, CYSC_ECOUT
A4WDV5, CYSC_ENT38B2VG00, CYSC_ERWT9B7LWK5, CYSC_ESCF3
B9M543, CYSC_GEODFA5G863, CYSC_GEOURB7K8N5, CYSC_GLOC7
B8D0S4, CYSC_HALOHB5XV31, CYSC_KLEP3A6TD42, CYSC_KLEP7
Q88X60, CYSC_LACPLA1U3X8, CYSC_MARN8B0JL16, CYSC_MICAN
Q1D6P1, CYSC_MYXXDQ8EQN3, CYSC_OCEIHB2T3K5, CYSC_PARPJ
Q13ZJ7, CYSC_PARXLA6KXG9, CYSC_PHOV8B1XN05, CYSC_PICP2
Q7VE24, CYSC_PROMAP57702, CYSC_PSEAEP29811, CYSC_PSEAI
Q1I2K4, CYSC_PSEE4P56858, CYSC_PYRABQ7UQW3, CYSC_RHOBA
B7K5B1, CYSC_RIPO1B5F414, CYSC_SALA4A9MF25, CYSC_SALAR
Q57KJ1, CYSC_SALCHB5FTS8, CYSC_SALDCB5QW21, CYSC_SALEP
B5RDQ6, CYSC_SALG2B4TFX0, CYSC_SALHSB4T460, CYSC_SALNS
Q5PEH3, CYSC_SALPAA9N2D7, CYSC_SALPBC0PXB0, CYSC_SALPC
B5BEY7, CYSC_SALPKB4TTW4, CYSC_SALSVP63890, CYSC_SALTI
P63889, CYSC_SALTYA1S9N4, CYSC_SHEAMB8EE63, CYSC_SHEB2
A3D819, CYSC_SHEB5A6WJU6, CYSC_SHEB8A9L392, CYSC_SHEB9
Q12QM6, CYSC_SHEDOQ07Y94, CYSC_SHEFNB0TTD2, CYSC_SHEHH
Q8EB13, CYSC_SHEONA8H0A6, CYSC_SHEPAA4Y9X0, CYSC_SHEPC
A0KTI5, CYSC_SHESAQ0HFM7, CYSC_SHESMQ0HYA3, CYSC_SHESR
A1RGG0, CYSC_SHESWB2TZI1, CYSC_SHIB3Q31XB2, CYSC_SHIBS
Q32CI0, CYSC_SHIDSQ0T1I1, CYSC_SHIF8Q83JX9, CYSC_SHIFL
Q3YYB2, CYSC_SHISSB9DLK2, CYSC_STACTQ5HL02, CYSC_STAEQ
Q8CR04, CYSC_STAESQ4L9E6, CYSC_STAHJQ49UM5, CYSC_STAS1
Q2JUC0, CYSC_SYNJAQ2JLM3, CYSC_SYNJBP72940, CYSC_SYNY3
Q8DJ87, CYSC_THEVBB5YJA6, CYSC_THEYDQ9KP21, CYSC_VIBCH
Q87SX6, CYSC_VIBPAQ8DE75, CYSC_VIBVUQ7MPF0, CYSC_VIBVY
Q8ZBP3, CYSC_YERPEP9WNM4, CYSNC_MYCTOP9WNM5, CYSNC_MYCTU
O50274, CYSNC_PSEAEQ7UMW2, CYSNC_RHOBAQ9PD78, CYSNC_XYLFA
Q87DG7, CYSNC_XYLFTO49204, KAPS_CATROQ92203, KAPS_EMENI
Q12657, KAPS_PENCHQ9HGF8, KAPS_SACBAQ9C2Y6, KAPS_SACPS
Q9P7G9, KAPS_SCHPOQ02196, KAPS_YEASTP28604, NODQ_AZOBR
P13442, NODQ_RHIMEP72339, NODQ_RHIS3O07309, NODQ_RHISB
P52978, NODQ_RHITRO54820, PAPS1_CAVPOO43252, PAPS1_HUMAN
Q60967, PAPS1_MOUSEO95340, PAPS2_HUMANO88428, PAPS2_MOUSE
A0A061AE05, PAPSH_CAEELQ27128, PAPSS_URECAA9ENT2, SATC1_SORC5
A9G7W0, SATC2_SORC5O67174, SATC_AQUAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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