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ENZYME

ENZYME entry: EC 2.7.7.4

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.4
Accepted Name
sulfate adenylyltransferase
Alternative Name(s)
ATP-sulfurylase
sulfate adenylate transferase
sulfurylase
Reaction catalysed
sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate
Comment(s)
  • The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.
  • This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.
Cross-references
BRENDA2.7.7.4
EC2PDB2.7.7.4
ExplorEnz2.7.7.4
KEGG Ligand Database for Enzyme Nomenclature2.7.7.4
IUBMB Enzyme Nomenclature2.7.7.4
MEDLINEFind literature relating to 2.7.7.4
MetaCyc2.7.7.4
Rhea expert-curated reactions2.7.7.4
UniProtKB/Swiss-Prot
Q9LIK9, APS1_ARATHQ43870, APS2_ARATHO23324, APS3_ARATH
Q9S7D8, APS4_ARATHQ0A977, CYSD1_ALKEHQ1QWX0, CYSD1_CHRI1
A1U3Y0, CYSD1_MARN8A8FXJ5, CYSD1_SHESHQ0A653, CYSD2_ALKEH
Q1QUF8, CYSD2_CHRI1A1U490, CYSD2_MARN8A8FXM2, CYSD2_SHESH
Q6FDA0, CYSD_ACIADB0VSD7, CYSD_ACIBSB0V9N5, CYSD_ACIBY
A0KP36, CYSD_AERHHA4SRG9, CYSD_AERS4Q7D0L8, CYSD_AGRFC
B2URN8, CYSD_AKKM8A8EWR5, CYSD_ALIB4Q5E831, CYSD_ALIF1
B5FGJ8, CYSD_ALIFMB6ELP2, CYSD_ALISLB9JT86, CYSD_ALLAM
C1DQ71, CYSD_AZOVDQ5LES4, CYSD_BACFNQ64VR0, CYSD_BACFR
Q8AAQ0, CYSD_BACTNQ1LTP5, CYSD_BAUCHA5E8X6, CYSD_BRASB
A4YYA7, CYSD_BRASOQ2YP46, CYSD_BRUA2A6WVC7, CYSD_BRUA4
Q57FI5, CYSD_BRUABA9M7D7, CYSD_BRUC2C0RGP5, CYSD_BRUMB
Q8YEX2, CYSD_BRUMEA5VNC5, CYSD_BRUO2B0CJ51, CYSD_BRUSI
Q8G2W6, CYSD_BRUSUB8D9K2, CYSD_BUCA5P57499, CYSD_BUCAI
B8D7V4, CYSD_BUCATQ39EM7, CYSD_BURL3B0T3J3, CYSD_CAUSK
Q9A881, CYSD_CAUVCQ11K42, CYSD_CHESBA4SDU0, CYSD_CHLPM
Q7NVN6, CYSD_CHRVOB5EF56, CYSD_CITBBA8ANW6, CYSD_CITK8
Q483A0, CYSD_COLP3A7MJ68, CYSD_CROS8A7ZQJ6, CYSD_ECO24
B7UHH1, CYSD_ECO27B7MKM6, CYSD_ECO45B7LEH0, CYSD_ECO55
Q8X7X4, CYSD_ECO57B5Z3B4, CYSD_ECO5EB7NT96, CYSD_ECO7I
B7MZ53, CYSD_ECO81B7LXG4, CYSD_ECO8AC4ZZQ6, CYSD_ECOBW
B1XCS8, CYSD_ECODHA8A3N1, CYSD_ECOHSA1AEU6, CYSD_ECOK1
Q0TEA6, CYSD_ECOL5Q8FEJ0, CYSD_ECOL6B1IUS7, CYSD_ECOLC
P21156, CYSD_ECOLIB7N6Y2, CYSD_ECOLUB6I6E2, CYSD_ECOSE
B1LQ73, CYSD_ECOSMQ1R7T9, CYSD_ECOUTA4XQP2, CYSD_ECTM1
A4WDV7, CYSD_ENT38B2VG02, CYSD_ERWT9B7LWK3, CYSD_ESCF3
B9M197, CYSD_GEODFQ39RP7, CYSD_GEOMGC6E751, CYSD_GEOSM
A5G8G3, CYSD_GEOURQ2SBG0, CYSD_HAHCHA1WZK4, CYSD_HALHL
Q0C438, CYSD_HYPNAA6TD44, CYSD_KLEP7B5XV29, CYSD_KLEV3
A0L6E2, CYSD_MAGMMQ0ALV0, CYSD_MARMMA6VXC5, CYSD_MARMS
B7L0Y0, CYSD_METC4Q604B7, CYSD_METCAA9W4X2, CYSD_METEP
B8IRX8, CYSD_METNOB1Z7C1, CYSD_METPBB1LSA1, CYSD_METRJ
B0U8Y5, CYSD_METS4P65671, CYSD_MYCBOA1KI72, CYSD_MYCBP
A4T8Q2, CYSD_MYCGIA3Q3I2, CYSD_MYCSJA1UK27, CYSD_MYCSK
Q1B510, CYSD_MYCSSA5U1Y3, CYSD_MYCTAP9WIK0, CYSD_MYCTO
P9WIK1, CYSD_MYCTUA1TDE9, CYSD_MYCVPQ1D9W6, CYSD_MYXXD
Q5YUA1, CYSD_NOCFAA6LA51, CYSD_PARD8Q6D1A5, CYSD_PECAS
C6DDH0, CYSD_PECCPQ7N8L1, CYSD_PHOLLQ6LM68, CYSD_PHOPR
A6KXG8, CYSD_PHOV8B4F231, CYSD_PROMHQ48ED3, CYSD_PSE14
Q15VB5, CYSD_PSEA6B7UZY2, CYSD_PSEA8Q02GZ8, CYSD_PSEAB
O50273, CYSD_PSEAEQ1I585, CYSD_PSEE4Q4KI67, CYSD_PSEF5
C3KDP1, CYSD_PSEFSA5W8T2, CYSD_PSEP1A6VBB6, CYSD_PSEP7
Q3KHY6, CYSD_PSEPFB0KGN7, CYSD_PSEPGQ88NA9, CYSD_PSEPK
B1J166, CYSD_PSEPWQ87WW0, CYSD_PSESMQ3ILR0, CYSD_PSET1
Q4ZNW4, CYSD_PSEU2A1ST25, CYSD_PSYINB3PTD3, CYSD_RHIE6
Q2KB48, CYSD_RHIECQ1MJV3, CYSD_RHIJ3Q985Q5, CYSD_RHILO
B5ZUF6, CYSD_RHILWP56892, CYSD_RHIMEB9JB96, CYSD_RHIR8
O33580, CYSD_RHITRQ07UU1, CYSD_RHOP5Q21D94, CYSD_RHOPB
Q2RS06, CYSD_RHORTQ21IS4, CYSD_SACD2B5F416, CYSD_SALA4
A9MF23, CYSD_SALARQ57KI9, CYSD_SALCHB5FTT0, CYSD_SALDC
B5QW23, CYSD_SALEPB5RDQ8, CYSD_SALG2B4TFX2, CYSD_SALHS
B4T462, CYSD_SALNSQ5PEH1, CYSD_SALPAA9N2D9, CYSD_SALPB
B5BEY9, CYSD_SALPKB4TTW6, CYSD_SALSVP65673, CYSD_SALTI
P65672, CYSD_SALTYA8G9Y4, CYSD_SERP5A1S9N7, CYSD_SHEAM
B8EE60, CYSD_SHEB2A3D822, CYSD_SHEB5A6WJU3, CYSD_SHEB8
A9L389, CYSD_SHEB9Q12QM9, CYSD_SHEDOQ07Y91, CYSD_SHEFN
B0TTD5, CYSD_SHEHHA3QCU1, CYSD_SHELPQ8EB09, CYSD_SHEON
A8H0A3, CYSD_SHEPAA4Y9X3, CYSD_SHEPCB8CSV0, CYSD_SHEPW
A0KTI2, CYSD_SHESAQ0HFM4, CYSD_SHESMQ0HYA6, CYSD_SHESR
A1RGF7, CYSD_SHESWB1KMH3, CYSD_SHEWMB2TZH9, CYSD_SHIB3
Q31XB4, CYSD_SHIBSQ32CH8, CYSD_SHIDSQ0T1I3, CYSD_SHIF8
P59740, CYSD_SHIFLQ3YYB0, CYSD_SHISSQ2NVM9, CYSD_SODGM
A4VIE6, CYSD_STUS1Q30U93, CYSD_SULDNA6QB13, CYSD_SULNB
Q3A3P5, CYSD_SYNC1B3E8X9, CYSD_TRIL1B7VKY3, CYSD_VIBA3
A7MWG4, CYSD_VIBC1A5F579, CYSD_VIBC3Q9KP19, CYSD_VIBCH
C3LRM2, CYSD_VIBCMQ87SY0, CYSD_VIBPAQ8DE72, CYSD_VIBVU
Q7MPF3, CYSD_VIBVYQ8PHD0, CYSD_XANACQ4UY06, CYSD_XANC8
B0RPG8, CYSD_XANCBQ8P610, CYSD_XANCPQ3BPY6, CYSD_XANE5
Q2P0H4, CYSD_XANOMB2SI03, CYSD_XANOPQ9PD79, CYSD_XYLFA
Q87DG8, CYSD_XYLFTA1JJS9, CYSD_YERE8A7FLY3, CYSD_YERP3
Q1C483, CYSD_YERPAB2K572, CYSD_YERPBQ8ZBP1, CYSD_YERPE
A9R1C3, CYSD_YERPGQ1CLS1, CYSD_YERPNA4TPZ2, CYSD_YERPP
Q66EC8, CYSD_YERPSB1JJG3, CYSD_YERPYQ5NRM5, CYSD_ZYMMO
P9WNM4, CYSNC_MYCTOP9WNM5, CYSNC_MYCTUO50274, CYSNC_PSEAE
Q7UMW2, CYSNC_RHOBAQ9PD78, CYSNC_XYLFAQ87DG7, CYSNC_XYLFT
A0KP35, CYSN_AERHHA4SRG8, CYSN_AERS4Q8UH69, CYSN_AGRFC
A8EWR6, CYSN_ALIB4Q5E830, CYSN_ALIF1B5FGJ9, CYSN_ALIFM
B6ELP3, CYSN_ALISLB4RTW4, CYSN_ALTMDQ5LES3, CYSN_BACFN
Q64VQ9, CYSN_BACFRQ8AAP9, CYSN_BACTNB8D9K1, CYSN_BUCA5
P57498, CYSN_BUCAIB8D7V3, CYSN_BUCATB3PII1, CYSN_CELJU
Q1QUF9, CYSN_CHRI1Q7NVN5, CYSN_CHRVOA8ANW5, CYSN_CITK8
Q482Z9, CYSN_COLP3A7MJ69, CYSN_CROS8A7ZQJ5, CYSN_ECO24
B7UHH0, CYSN_ECO27B7MKM5, CYSN_ECO45B7LEG9, CYSN_ECO55
Q8X7X7, CYSN_ECO57B5Z3B3, CYSN_ECO5EB7NT95, CYSN_ECO7I
B7MZ52, CYSN_ECO81B7LXG3, CYSN_ECO8AC4ZZQ5, CYSN_ECOBW
B1XCS7, CYSN_ECODHA8A3N0, CYSN_ECOHSA1AEU5, CYSN_ECOK1
Q0TEA7, CYSN_ECOL5Q8FEJ1, CYSN_ECOL6B1IUS8, CYSN_ECOLC
P23845, CYSN_ECOLIB7N6Y1, CYSN_ECOLUB6I6E1, CYSN_ECOSE
B1LQ72, CYSN_ECOSMQ1R7U0, CYSN_ECOUTB2VG01, CYSN_ERWT9
B7LWK4, CYSN_ESCF3Q14HG2, CYSN_FRAT1A0Q6F0, CYSN_FRATN
Q5NG10, CYSN_FRATTA4IXZ5, CYSN_FRATWC1D890, CYSN_LARHH
B7L0X9, CYSN_METC4A9W4X1, CYSN_METEPB1Z7C0, CYSN_METPB
Q7N8L0, CYSN_PHOLLQ6LM69, CYSN_PHOPRQ15VB8, CYSN_PSEA6
A1ST27, CYSN_PSYINP56893, CYSN_RHIMEB9JB95, CYSN_RHIR8
O33581, CYSN_RHITRQ21IS6, CYSN_SACD2B5F415, CYSN_SALA4
A9MF24, CYSN_SALARQ57KJ0, CYSN_SALCHB5FTS9, CYSN_SALDC
B5QW22, CYSN_SALEPB5RDQ7, CYSN_SALG2B4TFX1, CYSN_SALHS
B4T461, CYSN_SALNSQ5PEH2, CYSN_SALPAA9N2D8, CYSN_SALPB
C0PXB1, CYSN_SALPCB5BEY8, CYSN_SALPKB4TTW5, CYSN_SALSV
Q8Z470, CYSN_SALTIQ8ZMF5, CYSN_SALTYQ8EB10, CYSN_SHEON
B1KMH4, CYSN_SHEWMB2TZI0, CYSN_SHIB3Q31XB3, CYSN_SHIBS
Q32CH9, CYSN_SHIDSQ0T1I2, CYSN_SHIF8Q83JX8, CYSN_SHIFL
Q3YYB1, CYSN_SHISSQ2NVM8, CYSN_SODGMA6QB12, CYSN_SULNB
C5BSJ5, CYSN_TERTTC4LAG3, CYSN_TOLATB7VKY2, CYSN_VIBA3
A7MWE9, CYSN_VIBC1A5F578, CYSN_VIBC3Q9KP20, CYSN_VIBCH
C3LRM1, CYSN_VIBCMQ87SX9, CYSN_VIBPAQ8DE73, CYSN_VIBVU
Q7MPF2, CYSN_VIBVYA1JJT0, CYSN_YERE8A7FLY2, CYSN_YERP3
Q8ZBP2, CYSN_YERPEQ66EC7, CYSN_YERPSA1CJC1, MET3_ASPCL
Q4WWN8, MET3_ASPFUQ8NJN1, MET3_ASPNGQ8NK83, MET3_ASPOR
P56862, MET3_ASPTEQ0CC19, MET3_ASPTNQ9Y872, MET3_CANAL
Q6FXQ8, MET3_CANGAQ2H454, MET3_CHAGBQ1EAF9, MET3_COCIM
P0CN04, MET3_CRYD1P0CN05, MET3_CRYD3Q8TG24, MET3_CRYN9
Q6BSU5, MET3_DEBHAQ12555, MET3_EMENIQ74ZF6, MET3_EREGS
Q4I1N3, MET3_GIBZEQ6CNU6, MET3_KLULAQ8J0I4, MET3_MUCCL
Q4P460, MET3_MYCMDA1D858, MET3_NEOFIQ7SE75, MET3_NEUCR
Q12650, MET3_PENCHQ0V6P9, MET3_PHANOP78937, MET3_SCHPO
Q6CFD2, MET3_YARLIP08536, MET3_YEASTQ9X5U0, MMCV_STRLA
P28603, NODP_AZOBRP13441, NODP_RHIMEP72338, NODP_RHIS3
O07308, NODP_RHISBP52995, NODP_RHITRP28604, NODQ_AZOBR
P13442, NODQ_RHIMEP72339, NODQ_RHIS3O07309, NODQ_RHISB
P52978, NODQ_RHITRO54820, PAPS1_CAVPOO43252, PAPS1_HUMAN
Q60967, PAPS1_MOUSEO95340, PAPS2_HUMANO88428, PAPS2_MOUSE
A0A061AE05, PAPSH_CAEELQ27128, PAPSS_URECAO34764, SAT1_BACSU
O06736, SAT2_BACSUA9ENT2, SATC1_SORC5A9G7W0, SATC2_SORC5
O67174, SATC_AQUAEB0BZ94, SAT_ACAM1Q9YCR4, SAT_AERPE
Q0VRM0, SAT_ALCBSO66036, SAT_ALLVDO28606, SAT_ARCFU
C3P517, SAT_BACAAC3L9N5, SAT_BACACA0RBN3, SAT_BACAH
Q81T48, SAT_BACANB7JGQ4, SAT_BACC0Q73B75, SAT_BACC1
B7INB5, SAT_BACC2C1EMR9, SAT_BACC3B7HHH7, SAT_BACC4
B7HKE6, SAT_BACC7A7GMW1, SAT_BACCNB9IV12, SAT_BACCQ
Q81FZ0, SAT_BACCRQ63DV8, SAT_BACCZQ6HLD3, SAT_BACHK
Q65JT9, SAT_BACLDA9VLJ0, SAT_BACMKA8FD24, SAT_BACP2
A7Z4H9, SAT_BACVZQ3A8R0, SAT_CARHZA0RYU6, SAT_CENSY
A9WFJ2, SAT_CHLAAQ3AQ83, SAT_CHLCHB3ELG8, SAT_CHLPB
B9LKB9, SAT_CHLSYQ8KE30, SAT_CHLTEC1CVW9, SAT_DEIDV
Q1IYH9, SAT_DEIGDP56864, SAT_DEIRAB8FB52, SAT_DESAL
B1I3M7, SAT_DESAPB8J4A8, SAT_DESDAA4J272, SAT_DESRM
O76156, SAT_ENTH1Q5L2Y0, SAT_GEOKAC5D5A6, SAT_GEOSW
A4IKB5, SAT_GEOTNQ7NLN7, SAT_GLOVIB8D0S5, SAT_HALOH
A2BMW0, SAT_HYPBUA8AB48, SAT_IGNH4Q88X61, SAT_LACPL
B1HXC8, SAT_LYSSCB0JW81, SAT_MICANA9A541, SAT_NITMS
B2J5M3, SAT_NOSP7Q8EQN5, SAT_OCEIHB4SAM9, SAT_PELPB
A5D5R7, SAT_PELTSC0QSU0, SAT_PERMHA9BFU2, SAT_PETMO
B1XLP7, SAT_PICP2P84547, SAT_POPEUQ4FST7, SAT_PSYA2
Q1QAY1, SAT_PSYCKA5WEH0, SAT_PSYWFP56863, SAT_PYRAB
Q60FC6, SAT_PYRYEQ54506, SAT_RIFPSB7JVS6, SAT_RIPO1
Q1AXE5, SAT_RUBXDA1AVC7, SAT_RUTMCQ5WKF4, SAT_SHOC1
B9DLL5, SAT_STACTQ5HL01, SAT_STAEQQ8CR03, SAT_STAES
Q4L9E7, SAT_STAHJA3DLD9, SAT_STAMFQ49UM4, SAT_STAS1
Q67QB5, SAT_SYMTHQ31RJ2, SAT_SYNE7A0LH38, SAT_SYNFM
Q2JU97, SAT_SYNJAQ5N2R3, SAT_SYNP6P74241, SAT_SYNY3
B6YUW9, SAT_THEONQ3SEZ6, SAT_THIDAQ111K4, SAT_TRIEI
Q3MAI6, SAT_TRIV2A5CXS6, SAT_VESOH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-