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ENZYME

ENZYME entry: EC 2.7.7.4

Accepted Name
sulfate adenylyltransferase
Alternative Name(s)
ATP-sulfurylase
sulfate adenylate transferase
sulfurylase
Reaction catalysed
ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate
Comment(s)
  • The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.
  • This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.
Cross-references
BRENDA2.7.7.4
EC2PDB2.7.7.4
ExplorEnz2.7.7.4
PRIAM enzyme-specific profiles2.7.7.4
KEGG Ligand Database for Enzyme Nomenclature2.7.7.4
IUBMB Enzyme Nomenclature2.7.7.4
IntEnz2.7.7.4
MEDLINEFind literature relating to 2.7.7.4
MetaCyc2.7.7.4
Rhea expert-curated reactions2.7.7.4
UniProtKB/Swiss-Prot
Q9LIK9, APS1_ARATHQ43870, APS2_ARATHO23324, APS3_ARATH
Q9S7D8, APS4_ARATHQ0A977, CYSD1_ALKEHQ1QWX0, CYSD1_CHRSD
A1U3Y0, CYSD1_MARN8A8FXJ5, CYSD1_SHESHQ0A653, CYSD2_ALKEH
Q1QUF8, CYSD2_CHRSDA1U490, CYSD2_MARN8A8FXM2, CYSD2_SHESH
Q6FDA0, CYSD_ACIADB0VSD7, CYSD_ACIBSB0V9N5, CYSD_ACIBY
A0KP36, CYSD_AERHHA4SRG9, CYSD_AERS4Q7D0L8, CYSD_AGRFC
B9JB96, CYSD_AGRRKB9JT86, CYSD_AGRVSB2URN8, CYSD_AKKM8
A8EWR5, CYSD_ALIB4Q5E831, CYSD_ALIF1B5FGJ8, CYSD_ALIFM
B6ELP2, CYSD_ALISLC1DQ71, CYSD_AZOVDQ5LES4, CYSD_BACFN
Q64VR0, CYSD_BACFRQ8AAQ0, CYSD_BACTNQ1LTP5, CYSD_BAUCH
A5E8X6, CYSD_BRASBA4YYA7, CYSD_BRASOQ2YP46, CYSD_BRUA2
A6WVC7, CYSD_BRUA4Q57FI5, CYSD_BRUABA9M7D7, CYSD_BRUC2
C0RGP5, CYSD_BRUMBQ8YEX2, CYSD_BRUMEA5VNC5, CYSD_BRUO2
B0CJ51, CYSD_BRUSIQ8G2W6, CYSD_BRUSUB8D9K2, CYSD_BUCA5
P57499, CYSD_BUCAIB8D7V4, CYSD_BUCATQ39EM7, CYSD_BURL3
B0T3J3, CYSD_CAUSKQ9A881, CYSD_CAUVCQ11K42, CYSD_CHESB
A4SDU0, CYSD_CHLPMQ7NVN6, CYSD_CHRVOB5EF56, CYSD_CITBB
A8ANW6, CYSD_CITK8Q483A0, CYSD_COLP3A7MJ68, CYSD_CROS8
A7ZQJ6, CYSD_ECO24B7UHH1, CYSD_ECO27B7MKM6, CYSD_ECO45
B7LEH0, CYSD_ECO55Q8X7X4, CYSD_ECO57B5Z3B4, CYSD_ECO5E
B7NT96, CYSD_ECO7IB7MZ53, CYSD_ECO81B7LXG4, CYSD_ECO8A
C4ZZQ6, CYSD_ECOBWB1XCS8, CYSD_ECODHA8A3N1, CYSD_ECOHS
A1AEU6, CYSD_ECOK1Q0TEA6, CYSD_ECOL5Q8FEJ0, CYSD_ECOL6
B1IUS7, CYSD_ECOLCP21156, CYSD_ECOLIB7N6Y2, CYSD_ECOLU
B6I6E2, CYSD_ECOSEB1LQ73, CYSD_ECOSMQ1R7T9, CYSD_ECOUT
A4WDV7, CYSD_ENT38B2VG02, CYSD_ERWT9B7LWK3, CYSD_ESCF3
B9M197, CYSD_GEODFQ39RP7, CYSD_GEOMGC6E751, CYSD_GEOSM
A5G8G3, CYSD_GEOURQ2SBG0, CYSD_HAHCHA1WZK4, CYSD_HALHL
Q0C438, CYSD_HYPNAB5XV29, CYSD_KLEP3A6TD44, CYSD_KLEP7
A0L6E2, CYSD_MAGMMQ0ALV0, CYSD_MARMMA6VXC5, CYSD_MARMS
B7L0Y0, CYSD_METC4Q604B7, CYSD_METCAA9W4X2, CYSD_METEP
B8IRX8, CYSD_METNOB1Z7C1, CYSD_METPBB1LSA1, CYSD_METRJ
B0U8Y5, CYSD_METS4P65671, CYSD_MYCBOA1KI72, CYSD_MYCBP
A4T8Q2, CYSD_MYCGIA3Q3I2, CYSD_MYCSJA1UK27, CYSD_MYCSK
Q1B510, CYSD_MYCSSA5U1Y3, CYSD_MYCTAP9WIK0, CYSD_MYCTO
P9WIK1, CYSD_MYCTUA1TDE9, CYSD_MYCVPQ1D9W6, CYSD_MYXXD
Q5YUA1, CYSD_NOCFAA6LA51, CYSD_PARD8Q6D1A5, CYSD_PECAS
C6DDH0, CYSD_PECCPQ7N8L1, CYSD_PHOLLQ6LM68, CYSD_PHOPR
A6KXG8, CYSD_PHOV8B4F231, CYSD_PROMHQ48ED3, CYSD_PSE14
Q15VB5, CYSD_PSEA6A6VBB6, CYSD_PSEA7B7UZY2, CYSD_PSEA8
Q02GZ8, CYSD_PSEABO50273, CYSD_PSEAEQ1I585, CYSD_PSEE4
Q4KI67, CYSD_PSEF5C3KDP1, CYSD_PSEFSA4XQP2, CYSD_PSEMY
A5W8T2, CYSD_PSEP1Q3KHY6, CYSD_PSEPFB0KGN7, CYSD_PSEPG
Q88NA9, CYSD_PSEPKB1J166, CYSD_PSEPWQ87WW0, CYSD_PSESM
Q3ILR0, CYSD_PSET1Q4ZNW4, CYSD_PSEU2A4VIE6, CYSD_PSEU5
A1ST25, CYSD_PSYINB3PTD3, CYSD_RHIE6Q2KB48, CYSD_RHIEC
Q1MJV3, CYSD_RHIL3Q985Q5, CYSD_RHILOB5ZUF6, CYSD_RHILW
P56892, CYSD_RHIMEO33580, CYSD_RHITRQ07UU1, CYSD_RHOP5
Q21D94, CYSD_RHOPBQ2RS06, CYSD_RHORTQ21IS4, CYSD_SACD2
B5F416, CYSD_SALA4A9MF23, CYSD_SALARQ57KI9, CYSD_SALCH
B5FTT0, CYSD_SALDCB5QW23, CYSD_SALEPB5RDQ8, CYSD_SALG2
B4TFX2, CYSD_SALHSB4T462, CYSD_SALNSQ5PEH1, CYSD_SALPA
A9N2D9, CYSD_SALPBB5BEY9, CYSD_SALPKB4TTW6, CYSD_SALSV
P65673, CYSD_SALTIP65672, CYSD_SALTYA8G9Y4, CYSD_SERP5
A1S9N7, CYSD_SHEAMB8EE60, CYSD_SHEB2A3D822, CYSD_SHEB5
A6WJU3, CYSD_SHEB8A9L389, CYSD_SHEB9Q12QM9, CYSD_SHEDO
Q07Y91, CYSD_SHEFNB0TTD5, CYSD_SHEHHA3QCU1, CYSD_SHELP
Q8EB09, CYSD_SHEONA8H0A3, CYSD_SHEPAA4Y9X3, CYSD_SHEPC
B8CSV0, CYSD_SHEPWA0KTI2, CYSD_SHESAQ0HFM4, CYSD_SHESM
Q0HYA6, CYSD_SHESRA1RGF7, CYSD_SHESWB1KMH3, CYSD_SHEWM
B2TZH9, CYSD_SHIB3Q31XB4, CYSD_SHIBSQ32CH8, CYSD_SHIDS
Q0T1I3, CYSD_SHIF8P59740, CYSD_SHIFLQ3YYB0, CYSD_SHISS
Q2NVM9, CYSD_SODGMQ30U93, CYSD_SULDNA6QB13, CYSD_SULNB
Q3A3P5, CYSD_SYNC1B3E8X9, CYSD_TRIL1B7VKY3, CYSD_VIBA3
A7MWG4, CYSD_VIBC1A5F579, CYSD_VIBC3Q9KP19, CYSD_VIBCH
C3LRM2, CYSD_VIBCMQ87SY0, CYSD_VIBPAQ8DE72, CYSD_VIBVU
Q7MPF3, CYSD_VIBVYQ8PHD0, CYSD_XANACQ3BPY6, CYSD_XANC5
Q4UY06, CYSD_XANC8B0RPG8, CYSD_XANCBQ8P610, CYSD_XANCP
Q2P0H4, CYSD_XANOMB2SI03, CYSD_XANOPQ9PD79, CYSD_XYLFA
Q87DG8, CYSD_XYLFTA1JJS9, CYSD_YERE8A7FLY3, CYSD_YERP3
Q1C483, CYSD_YERPAB2K572, CYSD_YERPBQ8ZBP1, CYSD_YERPE
A9R1C3, CYSD_YERPGQ1CLS1, CYSD_YERPNA4TPZ2, CYSD_YERPP
Q66EC8, CYSD_YERPSB1JJG3, CYSD_YERPYQ5NRM5, CYSD_ZYMMO
P9WNM4, CYSNC_MYCTOP9WNM5, CYSNC_MYCTUO50274, CYSNC_PSEAE
Q7UMW2, CYSNC_RHOBAQ9PD78, CYSNC_XYLFAQ87DG7, CYSNC_XYLFT
A0KP35, CYSN_AERHHA4SRG8, CYSN_AERS4Q8UH69, CYSN_AGRFC
B9JB95, CYSN_AGRRKA8EWR6, CYSN_ALIB4Q5E830, CYSN_ALIF1
B5FGJ9, CYSN_ALIFMB6ELP3, CYSN_ALISLB4RTW4, CYSN_ALTMD
Q5LES3, CYSN_BACFNQ64VQ9, CYSN_BACFRQ8AAP9, CYSN_BACTN
B8D9K1, CYSN_BUCA5P57498, CYSN_BUCAIB8D7V3, CYSN_BUCAT
B3PII1, CYSN_CELJUQ1QUF9, CYSN_CHRSDQ7NVN5, CYSN_CHRVO
A8ANW5, CYSN_CITK8Q482Z9, CYSN_COLP3A7MJ69, CYSN_CROS8
A7ZQJ5, CYSN_ECO24B7UHH0, CYSN_ECO27B7MKM5, CYSN_ECO45
B7LEG9, CYSN_ECO55Q8X7X7, CYSN_ECO57B5Z3B3, CYSN_ECO5E
B7NT95, CYSN_ECO7IB7MZ52, CYSN_ECO81B7LXG3, CYSN_ECO8A
C4ZZQ5, CYSN_ECOBWB1XCS7, CYSN_ECODHA8A3N0, CYSN_ECOHS
A1AEU5, CYSN_ECOK1Q0TEA7, CYSN_ECOL5Q8FEJ1, CYSN_ECOL6
B1IUS8, CYSN_ECOLCP23845, CYSN_ECOLIB7N6Y1, CYSN_ECOLU
B6I6E1, CYSN_ECOSEB1LQ72, CYSN_ECOSMQ1R7U0, CYSN_ECOUT
B2VG01, CYSN_ERWT9B7LWK4, CYSN_ESCF3Q14HG2, CYSN_FRAT1
A0Q6F0, CYSN_FRATNQ5NG10, CYSN_FRATTA4IXZ5, CYSN_FRATW
C1D890, CYSN_LARHHB7L0X9, CYSN_METC4A9W4X1, CYSN_METEP
B1Z7C0, CYSN_METPBQ7N8L0, CYSN_PHOLLQ6LM69, CYSN_PHOPR
Q15VB8, CYSN_PSEA6A1ST27, CYSN_PSYINP56893, CYSN_RHIME
O33581, CYSN_RHITRQ21IS6, CYSN_SACD2B5F415, CYSN_SALA4
A9MF24, CYSN_SALARQ57KJ0, CYSN_SALCHB5FTS9, CYSN_SALDC
B5QW22, CYSN_SALEPB5RDQ7, CYSN_SALG2B4TFX1, CYSN_SALHS
B4T461, CYSN_SALNSQ5PEH2, CYSN_SALPAA9N2D8, CYSN_SALPB
C0PXB1, CYSN_SALPCB5BEY8, CYSN_SALPKB4TTW5, CYSN_SALSV
Q8Z470, CYSN_SALTIQ8ZMF5, CYSN_SALTYQ8EB10, CYSN_SHEON
B1KMH4, CYSN_SHEWMB2TZI0, CYSN_SHIB3Q31XB3, CYSN_SHIBS
Q32CH9, CYSN_SHIDSQ0T1I2, CYSN_SHIF8Q83JX8, CYSN_SHIFL
Q3YYB1, CYSN_SHISSQ2NVM8, CYSN_SODGMA6QB12, CYSN_SULNB
C5BSJ5, CYSN_TERTTC4LAG3, CYSN_TOLATB7VKY2, CYSN_VIBA3
A7MWE9, CYSN_VIBC1A5F578, CYSN_VIBC3Q9KP20, CYSN_VIBCH
C3LRM1, CYSN_VIBCMQ87SX9, CYSN_VIBPAQ8DE73, CYSN_VIBVU
Q7MPF2, CYSN_VIBVYA1JJT0, CYSN_YERE8A7FLY2, CYSN_YERP3
Q8ZBP2, CYSN_YERPEQ66EC7, CYSN_YERPSQ74ZF6, MET3_ASHGO
A1CJC1, MET3_ASPCLQ4WWN8, MET3_ASPFUQ8NJN1, MET3_ASPNG
Q8NK83, MET3_ASPORP56862, MET3_ASPTEQ0CC19, MET3_ASPTN
Q9Y872, MET3_CANALQ6FXQ8, MET3_CANGBQ2H454, MET3_CHAGB
Q1EAF9, MET3_COCIMP0CN05, MET3_CRYNBQ8TG24, MET3_CRYNH
P0CN04, MET3_CRYNJQ6BSU5, MET3_DEBHAQ12555, MET3_EMENI
Q4I1N3, MET3_GIBZEQ6CNU6, MET3_KLULCQ8J0I4, MET3_MUCCL
A1D858, MET3_NEOFIQ7SE75, MET3_NEUCRQ12650, MET3_PENCH
Q0V6P9, MET3_PHANOP78937, MET3_SCHPOQ4P460, MET3_USTMA
Q6CFD2, MET3_YARLIP08536, MET3_YEASTQ9X5U0, MMCV_STRLA
P28603, NODP_AZOBRP13441, NODP_RHIMEP72338, NODP_RHIS3
O07308, NODP_RHISBP52995, NODP_RHITRP28604, NODQ_AZOBR
P13442, NODQ_RHIMEP72339, NODQ_RHIS3O07309, NODQ_RHISB
P52978, NODQ_RHITRO54820, PAPS1_CAVPOO43252, PAPS1_HUMAN
Q60967, PAPS1_MOUSEO95340, PAPS2_HUMANO88428, PAPS2_MOUSE
A0A061AE05, PAPSH_CAEELQ27128, PAPSS_URECAO34764, SAT1_BACSU
O06736, SAT2_BACSUA9ENT2, SATC1_SORC5A9G7W0, SATC2_SORC5
O67174, SATC_AQUAEB0BZ94, SAT_ACAM1Q9YCR4, SAT_AERPE
Q0VRM0, SAT_ALCBSQ5WKF4, SAT_ALKCKO66036, SAT_ALLVD
O28606, SAT_ARCFUC3P517, SAT_BACAAC3L9N5, SAT_BACAC
A0RBN3, SAT_BACAHQ81T48, SAT_BACANB7JGQ4, SAT_BACC0
Q73B75, SAT_BACC1B7INB5, SAT_BACC2C1EMR9, SAT_BACC3
B7HHH7, SAT_BACC4B7HKE6, SAT_BACC7A7GMW1, SAT_BACCN
B9IV12, SAT_BACCQQ81FZ0, SAT_BACCRQ63DV8, SAT_BACCZ
Q6HLD3, SAT_BACHKQ65JT9, SAT_BACLDA9VLJ0, SAT_BACMK
A8FD24, SAT_BACP2A7Z4H9, SAT_BACVZQ3A8R0, SAT_CARHZ
A0RYU6, SAT_CENSYA9WFJ2, SAT_CHLAAQ3AQ83, SAT_CHLCH
B3ELG8, SAT_CHLPBB9LKB9, SAT_CHLSYQ8KE30, SAT_CHLTE
C1CVW9, SAT_DEIDVQ1IYH9, SAT_DEIGDP56864, SAT_DEIRA
B8FB52, SAT_DESALB1I3M7, SAT_DESAPB8J4A8, SAT_DESDA
A4J272, SAT_DESRMO76156, SAT_ENTH1Q5L2Y0, SAT_GEOKA
C5D5A6, SAT_GEOSWA4IKB5, SAT_GEOTNQ7NLN7, SAT_GLOVI
B8D0S5, SAT_HALOHA2BMW0, SAT_HYPBUA8AB48, SAT_IGNH4
Q88X61, SAT_LACPLB1HXC8, SAT_LYSSCB0JW81, SAT_MICAN
Q60FC6, SAT_NEOYEA9A541, SAT_NITMSB2J5M3, SAT_NOSP7
Q8EQN5, SAT_OCEIHB4SAM9, SAT_PELPBA5D5R7, SAT_PELTS
C0QSU0, SAT_PERMHA9BFU2, SAT_PETMOP84547, SAT_POPEU
Q4FST7, SAT_PSYA2Q1QAY1, SAT_PSYCKA5WEH0, SAT_PSYWF
P56863, SAT_PYRABQ54506, SAT_RIFPSB7JVS6, SAT_RIPO1
Q1AXE5, SAT_RUBXDA1AVC7, SAT_RUTMCB9DLL5, SAT_STACT
Q5HL01, SAT_STAEQQ8CR03, SAT_STAESQ4L9E7, SAT_STAHJ
A3DLD9, SAT_STAMFQ49UM4, SAT_STAS1Q67QB5, SAT_SYMTH
Q31RJ2, SAT_SYNE7A0LH38, SAT_SYNFMQ2JU97, SAT_SYNJA
B1XLP7, SAT_SYNP2Q5N2R3, SAT_SYNP6P74241, SAT_SYNY3
B6YUW9, SAT_THEONQ3SEZ6, SAT_THIDAQ111K4, SAT_TRIEI
Q3MAI6, SAT_TRIV2A5CXS6, SAT_VESOH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-