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ENZYME entry: EC 2.7.11.14

Accepted Name
rhodopsin kinase.
Alternative Name(s)
cone opsin kinase.
GPCR kinase 1.
G-protein-coupled receptor kinase 1.
opsin kinase.
opsin kinase (phosphorylating).
rhodopsin kinase (phosphorylating).
RK.
Reaction catalysed
  • ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]
  • ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]
Comment(s)
  • Acts on the bleached or activated form of rhodopsin.
  • Also phosphorylates the beta-adrenergic receptor, but more slowly.
  • Does not act on casein, histones or phosphovitin.
  • Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and EC 2.7.11.16).
  • Formerly EC 2.7.1.97 and EC 2.7.1.125.
Cross-references
BRENDA2.7.11.14
EC2PDB2.7.11.14
ExplorEnz2.7.11.14
PRIAM enzyme-specific profiles2.7.11.14
KEGG Ligand Database for Enzyme Nomenclature2.7.11.14
IUBMB Enzyme Nomenclature2.7.11.14
IntEnz2.7.11.14
MEDLINEFind literature relating to 2.7.11.14
MetaCyc2.7.11.14
Rhea expert-curated reactions2.7.11.14
UniProtKB/Swiss-Prot
P28327, GRK1_BOVIN;  Q15835, GRK1_HUMAN;  Q9WVL4, GRK1_MOUSE;  
Q63651, GRK1_RAT;  Q49HM9, GRK7A_DANRE;  B6CZ17, GRK7A_XENLA;  
Q1XHL7, GRK7B_DANRE;  B6CZ18, GRK7B_XENLA;  Q8WMV0, GRK7_BOVIN;  
Q8WTQ7, GRK7_HUMAN;  Q9Z2G7, GRK7_ICTTR;  Q8WP15, GRK7_PIG;  

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