ENZYME entry: EC 2.7.11.14
Accepted Name |
Rhodopsin kinase.
|
Alternative Name(s) |
Cone opsin kinase. |
G-protein-coupled receptor kinase 1. |
GPCR kinase 1. |
Opsin kinase. |
Opsin kinase (phosphorylating). |
Rhodopsin kinase (phosphorylating). |
RK. |
Reaction catalysed |
ATP + [rhodopsin] <=> ADP + [rhodopsin] phosphate |
Comment(s) |
- Acts on the bleached or activated form of rhodopsin.
- Also phosphorylates the beta-adrenergic receptor, but more slowly.
- Does not act on casein, histones or phosphovitin.
- Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and
EC 2.7.11.16).
- Formerly EC 2.7.1.97 and EC 2.7.1.125.
|
Cross-references |
PROSITE | PDOC00100 |
BRENDA | 2.7.11.14 |
EC2PDB | 2.7.11.14 |
ExplorEnz | 2.7.11.14 |
PRIAM enzyme-specific profiles | 2.7.11.14 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.14 |
IUBMB Enzyme Nomenclature | 2.7.11.14 |
IntEnz | 2.7.11.14 |
MEDLINE | Find literature relating to 2.7.11.14 |
MetaCyc | 2.7.11.14 |
Rhea expert-curated reactions | 2.7.11.14 |
UniProtKB/Swiss-Prot |
P28327, GRK1_BOVIN; | Q15835, GRK1_HUMAN; | Q9WVL4, GRK1_MOUSE; |
Q63651, GRK1_RAT; | Q49HM9, GRK7A_DANRE; | B6CZ17, GRK7A_XENLA; |
Q1XHL7, GRK7B_DANRE; | B6CZ18, GRK7B_XENLA; | Q8WMV0, GRK7_BOVIN; |
Q8WTQ7, GRK7_HUMAN; | Q9Z2G7, GRK7_ICTTR; | Q8WP15, GRK7_PIG; |
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