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ENZYME

ENZYME entry: EC 2.7.11.14

Accepted Name
rhodopsin kinase
Alternative Name(s)
cone opsin kinase
GPCR kinase 1
G-protein-coupled receptor kinase 1
opsin kinase
opsin kinase (phosphorylating)
rhodopsin kinase (phosphorylating)
RK
Reaction catalysed
  • ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]
  • ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]
Comment(s)
  • Acts on the bleached or activated form of rhodopsin.
  • Also phosphorylates the beta-adrenergic receptor, but more slowly.
  • Does not act on casein, histones or phosphovitin.
  • Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and EC 2.7.11.16).
  • Formerly EC 2.7.1.97 and EC 2.7.1.125.
Cross-references
BRENDA2.7.11.14
EC2PDB2.7.11.14
ExplorEnz2.7.11.14
PRIAM enzyme-specific profiles2.7.11.14
KEGG Ligand Database for Enzyme Nomenclature2.7.11.14
IUBMB Enzyme Nomenclature2.7.11.14
IntEnz2.7.11.14
MEDLINEFind literature relating to 2.7.11.14
MetaCyc2.7.11.14
Rhea expert-curated reactions2.7.11.14
UniProtKB/Swiss-Prot
P28327, GRK1_BOVINQ15835, GRK1_HUMANQ9WVL4, GRK1_MOUSE
Q63651, GRK1_RATQ49HM9, GRK7A_DANREB6CZ17, GRK7A_XENLA
Q1XHL7, GRK7B_DANREB6CZ18, GRK7B_XENLAQ8WMV0, GRK7_BOVIN
Q8WTQ7, GRK7_HUMANQ9Z2G7, GRK7_ICTTRQ8WP15, GRK7_PIG

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