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ENZYME entry: EC 2.7.11.16

Accepted Name
[G-protein-coupled receptor] kinase.
Alternative Name(s)
G protein-coupled receptor kinase.
GPCR kinase.
GPCRK.
Reaction catalysed
ATP + [G-protein-coupled receptor] <=> ADP + [G-protein-coupled receptor] phosphate
Comment(s)
  • All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate.
  • (cf. EC 2.7.11.14 and EC 2.7.11.15).
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.16
EC2PDB2.7.11.16
ExplorEnz2.7.11.16
PRIAM enzyme-specific profiles2.7.11.16
KEGG Ligand Database for Enzyme Nomenclature2.7.11.16
IUBMB Enzyme Nomenclature2.7.11.16
IntEnz2.7.11.16
MEDLINEFind literature relating to 2.7.11.16
MetaCyc2.7.11.16
Rhea expert-curated reactions2.7.11.16
UniProtKB/Swiss-Prot
P32865, GPRK1_DROME;  P32866, GPRK2_DROME;  Q622Z7, GRK1_CAEBR;  
Q09537, GRK1_CAEEL;  Q09639, GRK2_CAEEL;  P32298, GRK4_HUMAN;  
O70291, GRK4_MOUSE;  P70507, GRK4_RAT;  P43249, GRK5_BOVIN;  
P34947, GRK5_HUMAN;  Q8VEB1, GRK5_MOUSE;  Q62833, GRK5_RAT;  
P43250, GRK6_HUMAN;  O70293, GRK6_MOUSE;  P97711, GRK6_RAT;  

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