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ENZYME

ENZYME entry: EC 2.7.11.15

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.15
Accepted Name
[beta-adrenergic-receptor] kinase
Alternative Name(s)
ADRBK1
adrenergic receptor kinase
BARK1
beta2ARK
beta-adrenergic-receptor kinase
beta-adrenergic-receptor kinase (phosphorylating)
beta-adrenergic receptor-specific kinase
beta-adrenoceptor kinase
beta-ARK
beta-AR kinase
beta-receptor kinase
Reaction catalysed
[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)
Comment(s)
  • Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly.
  • Does not act on casein or histones.
  • Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16).
  • Formerly EC 2.7.1.126.
Cross-references
BRENDA2.7.11.15
EC2PDB2.7.11.15
ExplorEnz2.7.11.15
KEGG Ligand Database for Enzyme Nomenclature2.7.11.15
IUBMB Enzyme Nomenclature2.7.11.15
MEDLINEFind literature relating to 2.7.11.15
MetaCyc2.7.11.15
Rhea expert-curated reactions2.7.11.15
UniProtKB/Swiss-Prot
P21146, ARBK1_BOVINO97627, ARBK1_DIDVIP25098, ARBK1_HUMAN
Q64682, ARBK1_MESAUQ99MK8, ARBK1_MOUSEP26817, ARBK1_RAT
P26818, ARBK2_BOVINP35626, ARBK2_HUMANQ3UYH7, ARBK2_MOUSE
P26819, ARBK2_RAT

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