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ENZYME entry: EC 2.7.11.15

Accepted Name
[Beta-adrenergic-receptor] kinase.
Alternative Name(s)
ADRBK1.
Adrenergic receptor kinase.
BARK1.
Beta(2)ARK.
Beta-adrenergic receptor-specific kinase.
Beta-adrenergic-receptor kinase.
Beta-adrenergic-receptor kinase (phosphorylating).
Beta-adrenoceptor kinase.
Beta-AR kinase.
Beta-ARK.
Beta-receptor kinase.
Reaction catalysed
ATP + [beta-adrenergic receptor] <=> ADP + [beta-adrenergic receptor] phosphate
Comment(s)
  • Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly.
  • Does not act on casein or histones.
  • Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16).
  • Formerly EC 2.7.1.126.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.15
EC2PDB2.7.11.15
ExplorEnz2.7.11.15
PRIAM enzyme-specific profiles2.7.11.15
KEGG Ligand Database for Enzyme Nomenclature2.7.11.15
IUBMB Enzyme Nomenclature2.7.11.15
IntEnz2.7.11.15
MEDLINEFind literature relating to 2.7.11.15
MetaCyc2.7.11.15
Rhea expert-curated reactions2.7.11.15
UniProtKB/Swiss-Prot
P21146, ARBK1_BOVIN;  O97627, ARBK1_DIDVI;  P25098, ARBK1_HUMAN;  
Q64682, ARBK1_MESAU;  Q99MK8, ARBK1_MOUSE;  P26817, ARBK1_RAT;  
P26818, ARBK2_BOVIN;  P35626, ARBK2_HUMAN;  Q3UYH7, ARBK2_MOUSE;  
P26819, ARBK2_RAT;  

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