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ENZYME

ENZYME entry: EC 2.7.11.17

Accepted Name
calcium/calmodulin-dependent protein kinase
Alternative Name(s)
Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase
Ca(2+)/calmodulin-dependent protein kinase 1
Ca(2+)/calmodulin-dependent protein kinase II
Ca(2+)/calmodulin-dependent protein kinase IV
Ca(2+)/calmodulin-dependent protein kinase kinase
Ca(2+)/calmodulin-dependent protein kinase kinase beta
calcium/calmodulin-dependent protein kinase type II
caldesmon kinase
caldesmon kinase (phosphorylating)
calmodulin-dependent kinase II
CaMKI
CaMKII
CaM kinase
CaM kinase II
CaMKIV
CaMKKalpha
CaMKKbeta
CAM PKII
CaM-regulated serine/threonine kinase
microtubule-associated protein 2 kinase
Reaction catalysed
  • ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
Cross-references
BRENDA2.7.11.17
EC2PDB2.7.11.17
ExplorEnz2.7.11.17
PRIAM enzyme-specific profiles2.7.11.17
KEGG Ligand Database for Enzyme Nomenclature2.7.11.17
IUBMB Enzyme Nomenclature2.7.11.17
IntEnz2.7.11.17
MEDLINEFind literature relating to 2.7.11.17
MetaCyc2.7.11.17
Rhea expert-curated reactions2.7.11.17
UniProtKB/Swiss-Prot
Q10KY3, CAMK1_ORYSJW0LYS5, CAMKI_MACNPQ43531, CCAMK_LILLO
A0AAR7, CCAMK_LOTJAQ6RET7, CCAMK_MEDTRQ6AVM3, CCAMK_ORYSJ
Q6RET6, CCAMK_PEAA8X6H4, CMK1_CAEBRQ9TXJ0, CMK1_CAEEL
Q24210, CSKP_DROMEQ6DEH3, KC2D1_DANREQ6DGS3, KC2D2_DANRE
Q00771, KCC1A_EMENIQ14012, KCC1A_HUMANQ91YS8, KCC1A_MOUSE
Q63450, KCC1A_RATQ9Y899, KCC1B_EMENDQ6P2M8, KCC1B_HUMAN
Q9QYK9, KCC1B_MOUSEO70150, KCC1B_RATQ8IU85, KCC1D_HUMAN
Q8BW96, KCC1D_MOUSEQ96NX5, KCC1G_HUMANQ91VB2, KCC1G_MOUSE
Q7TNJ7, KCC1G_RATO14408, KCC1_METANQ9P7I2, KCC1_SCHPO
P27466, KCC1_YEASTQ00168, KCC2A_DROMEQ9UQM7, KCC2A_HUMAN
P11798, KCC2A_MOUSEQ5RCC4, KCC2A_PONABP11275, KCC2A_RAT
Q3MHJ9, KCC2B_BOVINQ13554, KCC2B_HUMANP28652, KCC2B_MOUSE
P08413, KCC2B_RATQ2HJF7, KCC2D_BOVINA8WXF6, KCC2D_CAEBR
O62305, KCC2D_CAEELQ5ZKI0, KCC2D_CHICKQ13557, KCC2D_HUMAN
Q6PHZ2, KCC2D_MOUSEQ95266, KCC2D_PIGO77708, KCC2D_RABIT
P15791, KCC2D_RATQ9DG02, KCC2D_XENLAQ13555, KCC2G_HUMAN
Q923T9, KCC2G_MOUSEP11730, KCC2G_RATO42844, KCC2_SCHPO
P22517, KCC2_YEASTQ16566, KCC4_HUMANP08414, KCC4_MOUSE
P13234, KCC4_RATQ07250, KCCS_MALDOQ8N5S9, KKCC1_HUMAN
Q8VBY2, KKCC1_MOUSEP97756, KKCC1_RATQ96RR4, KKCC2_HUMAN
Q8C078, KKCC2_MOUSEO88831, KKCC2_RATQ9Y898, KKCCC_EMEND
Q3Y416, KKCC_CAEEL

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