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ENZYME entry: EC 2.7.11.17

Accepted Name
Calcium/calmodulin-dependent protein kinase.
Alternative Name(s)
Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase.
Ca(2+)/calmodulin-dependent protein kinase 1.
Ca(2+)/calmodulin-dependent protein kinase II.
Ca(2+)/calmodulin-dependent protein kinase IV.
Ca(2+)/calmodulin-dependent protein kinase kinase.
Ca(2+)/calmodulin-dependent protein kinase kinase beta.
Calcium/calmodulin-dependent protein kinase type II.
Caldesmon kinase.
Caldesmon kinase (phosphorylating).
Calmodulin-dependent kinase II.
CaM kinase.
CaM kinase II.
CAM PKII.
CaM-regulated serine/threonine kinase.
CaMKI.
CaMKII.
CaMKIV.
CaMKK-alpha.
CaMKK-beta.
Microtubule-associated protein 2 kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Cofactor(s)
Ca(2+).
Comment(s)
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.17
EC2PDB2.7.11.17
ExplorEnz2.7.11.17
PRIAM enzyme-specific profiles2.7.11.17
KEGG Ligand Database for Enzyme Nomenclature2.7.11.17
IUBMB Enzyme Nomenclature2.7.11.17
IntEnz2.7.11.17
MEDLINEFind literature relating to 2.7.11.17
MetaCyc2.7.11.17
Rhea expert-curated reactions2.7.11.17
UniProtKB/Swiss-Prot
Q10KY3, CAMK1_ORYSJ;  W0LYS5, CAMKI_MACNP;  Q43531, CCAMK_LILLO;  
A0AAR7, CCAMK_LOTJA;  Q6RET7, CCAMK_MEDTR;  Q6AVM3, CCAMK_ORYSJ;  
Q6RET6, CCAMK_PEA;  A8X6H4, CMK1_CAEBR;  Q9TXJ0, CMK1_CAEEL;  
Q24210, CSKP_DROME;  Q6DEH3, KC2D1_DANRE;  Q6DGS3, KC2D2_DANRE;  
Q00771, KCC1A_EMENI;  Q14012, KCC1A_HUMAN;  Q91YS8, KCC1A_MOUSE;  
Q63450, KCC1A_RAT;  Q9Y899, KCC1B_EMEND;  Q6P2M8, KCC1B_HUMAN;  
Q9QYK9, KCC1B_MOUSE;  O70150, KCC1B_RAT;  Q8IU85, KCC1D_HUMAN;  
Q8BW96, KCC1D_MOUSE;  Q96NX5, KCC1G_HUMAN;  Q91VB2, KCC1G_MOUSE;  
Q7TNJ7, KCC1G_RAT;  O14408, KCC1_METAN;  Q9P7I2, KCC1_SCHPO;  
P27466, KCC1_YEAST;  Q00168, KCC2A_DROME;  Q9UQM7, KCC2A_HUMAN;  
P11798, KCC2A_MOUSE;  Q5RCC4, KCC2A_PONAB;  P11275, KCC2A_RAT;  
Q3MHJ9, KCC2B_BOVIN;  Q13554, KCC2B_HUMAN;  P28652, KCC2B_MOUSE;  
P08413, KCC2B_RAT;  Q2HJF7, KCC2D_BOVIN;  A8WXF6, KCC2D_CAEBR;  
O62305, KCC2D_CAEEL;  Q5ZKI0, KCC2D_CHICK;  Q13557, KCC2D_HUMAN;  
Q6PHZ2, KCC2D_MOUSE;  Q95266, KCC2D_PIG;  O77708, KCC2D_RABIT;  
P15791, KCC2D_RAT;  Q9DG02, KCC2D_XENLA;  Q13555, KCC2G_HUMAN;  
Q923T9, KCC2G_MOUSE;  P11730, KCC2G_RAT;  O42844, KCC2_SCHPO;  
P22517, KCC2_YEAST;  Q16566, KCC4_HUMAN;  P08414, KCC4_MOUSE;  
P13234, KCC4_RAT;  Q07250, KCCS_MALDO;  Q8N5S9, KKCC1_HUMAN;  
Q8VBY2, KKCC1_MOUSE;  P97756, KKCC1_RAT;  Q96RR4, KKCC2_HUMAN;  
Q8C078, KKCC2_MOUSE;  O88831, KKCC2_RAT;  Q9Y898, KKCCC_EMEND;  
Q3Y416, KKCC_CAEEL;  

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