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ENZYME

ENZYME entry: EC 2.7.11.24

Accepted Name
mitogen-activated protein kinase
Alternative Name(s)
c-Jun N-terminal kinase
ERK
extracellular signal-regulated kinase
JNK
MAPK
MAP kinase
MBP kinase I
MBP kinase II
microtubule-associated protein 2 kinase
microtubule-associated protein kinase
myelin basic protein kinase
SAPK
stress-activated protein kinase
Reaction catalysed
  • ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation.
  • Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline.
  • A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY).
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.24
EC2PDB2.7.11.24
ExplorEnz2.7.11.24
PRIAM enzyme-specific profiles2.7.11.24
KEGG Ligand Database for Enzyme Nomenclature2.7.11.24
IUBMB Enzyme Nomenclature2.7.11.24
IntEnz2.7.11.24
MEDLINEFind literature relating to 2.7.11.24
MetaCyc2.7.11.24
Rhea expert-curated reactions2.7.11.24
UniProtKB/Swiss-Prot
B0XXN8, BCK1_ASPFCQ4WXY0, BCK1_ASPFUP0CP67, CPK1_CRYNB
P0CP66, CPK1_CRYNJQ5A1D3, ERK1_CANALC4YGK0, ERK1_CANAW
P42525, ERK1_DICDIQ54QB1, ERK2_DICDIQ9W354, ERK7_DROME
P40417, ERKA_DROMEP16892, FUS3_YEASTA3EZ55, HOG1A_WALI9
M1T7M3, HOG1B_WALI9Q52PH6, HOG1_ALTBRA1CPG7, HOG1_ASPCL
Q4WSF6, HOG1_ASPFUQ38HL5, HOG1_ASPGLA2QRF6, HOG1_ASPNC
Q0D0P5, HOG1_ASPTNQ6PWX2, HOG1_BEABAQ702W0, HOG1_BLAAD
Q8TGA9, HOG1_BLUGRA1IVT7, HOG1_BOTFBQ92207, HOG1_CANAL
Q6FIU2, HOG1_CANGAQ2H332, HOG1_CHAGBQ4W6D3, HOG1_COCHE
Q1DUU8, HOG1_COCIMQ2WFL5, HOG1_COCMIQ75Q66, HOG1_COLOR
P0CP69, HOG1_CRYNBQ56R42, HOG1_CRYNHP0CP68, HOG1_CRYNJ
Q875L0, HOG1_CRYPAQ9UV50, HOG1_DEBHAQ9P419, HOG1_EMENI
Q750A9, HOG1_EREGSQ5I6M2, HOG1_EXSTUQ4PNJ1, HOG1_FUSCU
Q4PKS0, HOG1_GIBINP0C431, HOG1_GIBZEQ8NJT7, HOG1_HORWE
Q6XKY3, HOG1_HYPATQ6CJA8, HOG1_KLULAA1D2C9, HOG1_NEOFI
Q96TL5, HOG1_NEUCRQ0U4L8, HOG1_PHANOA3LN91, HOG1_PICST
Q9UV51, HOG1_PYRO7Q09892, HOG1_SCHPOQ1L5Z8, HOG1_TORDE
Q2WGK3, HOG1_TRIHAQ4PC06, HOG1_USTMAA3EZ53, HOG1_WALMU
A3EZ54, HOG1_WALSEQ6C4M9, HOG1_YARLIP32485, HOG1_YEAST
O93982, HOG1_ZYGRCO59854, HOG1_ZYGROQ1KTF2, HOG1_ZYMTI
O59853, HOG2_ZYGROQ9U6D2, JNK1_ANCCAQ8WQG9, JNK1_CAEEL
P92208, JNK_DROMEQ966Y3, JNK_SUBDOO44408, KGB1_CAEEL
P14681, KSS1_YEASTO94737, MAPK1_PNECAO42781, MAPK2_PNECA
Q00859, MAPK_FUSVNG4NDR3, MCK1_PYRO7P46196, MK01_BOVIN
P28482, MK01_HUMANP63085, MK01_MOUSEP63086, MK01_RAT
P26696, MK01_XENLAP27361, MK03_HUMANQ63844, MK03_MOUSE
P21708, MK03_RATP31152, MK04_HUMANQ6P5G0, MK04_MOUSE
Q63454, MK04_RATQ5F3W3, MK06_CHICKQ16659, MK06_HUMAN
Q61532, MK06_MOUSEQ5R7U1, MK06_PONABP27704, MK06_RAT
A5PKJ4, MK07_BOVINQ13164, MK07_HUMANQ9WVS8, MK07_MOUSE
P0C865, MK07_RATQ90327, MK08A_CYPCAO42099, MK08B_CYPCA
Q9DGD9, MK08_DANREP45983, MK08_HUMANQ91Y86, MK08_MOUSE
P49185, MK08_RATQ8QHK8, MK08_XENLAP79996, MK09_CHICK
P45984, MK09_HUMANQ9WTU6, MK09_MOUSEP49186, MK09_RAT
P53779, MK10_HUMANQ61831, MK10_MOUSEP49187, MK10_RAT
Q15759, MK11_HUMANQ9WUI1, MK11_MOUSEO42376, MK12_DANRE
P53778, MK12_HUMANO08911, MK12_MOUSEQ63538, MK12_RAT
Q3T0N5, MK13_BOVINO15264, MK13_HUMANQ9Z1B7, MK13_MOUSE
Q9N272, MK13_PANTRQ9WTY9, MK13_RATQ90336, MK14A_CYPCA
Q9DGE2, MK14A_DANREQ9I958, MK14B_CYPCAQ9DGE1, MK14B_DANRE
P83100, MK14C_DROMEO02812, MK14_CANLFQ16539, MK14_HUMAN
P47811, MK14_MOUSEQ95NE7, MK14_PANTRP70618, MK14_RAT
P47812, MK14_XENLAQ11179, MK15_CAEELQ8TD08, MK15_HUMAN
Q80Y86, MK15_MOUSEQ9Z2A6, MK15_RATQ501Q9, MK15_XENLA
Q9LKZ2, MK1_CAPANQ9LKZ1, MK2_CAPANO62618, MK38A_DROME
O61443, MK38B_DROMEQ5AAG6, MKC1_CANALP43068, MKC1_CANAX
B0XPE4, MKK2_ASPFCQ4WJJ0, MKK2_ASPFUG4N6Z6, MKK2_PYRO7
Q07176, MMK1_MEDSAQ40353, MMK2_MEDSAO81472, MP3K2_ARATH
Q9M1Z5, MPK10_ARATHQ5ZCI1, MPK10_ORYSJQ9LMM5, MPK11_ARATH
Q5VN19, MPK11_ORYSJQ8GYQ5, MPK12_ARATHQ5Z9J0, MPK12_ORYSJ
Q9LQQ9, MPK13_ARATHA2X0M1, MPK13_ORYSIQ0E459, MPK13_ORYSJ
O23236, MPK14_ARATHQ75KK8, MPK14_ORYSJQ9C9U4, MPK15_ARATH
Q53N72, MPK15_ORYSJQ8W4J2, MPK16_ARATHQ5VP69, MPK16_ORYSJ
Q84M93, MPK17_ARATHQ6L5F7, MPK17_ORYSJQ9C5C0, MPK18_ARATH
Q9LUC3, MPK19_ARATHQ39021, MPK1_ARATHP39745, MPK1_CAEEL
Q84UI5, MPK1_ORYSJQ9SJG9, MPK20_ARATHQ39022, MPK2_ARATH
Q5J4W4, MPK2_ORYSJQ39023, MPK3_ARATHQ6Z437, MPK3_ORYSJ
A9T142, MPK4A_PHYPAA9S9Q8, MPK4B_PHYPAQ39024, MPK4_ARATH
Q9GRU1, MPK4_LEIMEQ5Z859, MPK4_ORYSJQ39025, MPK5_ARATH
A2XFC8, MPK5_ORYSIQ10N20, MPK5_ORYSJQ39026, MPK6_ARATH
Q336X9, MPK6_ORYSJQ39027, MPK7_ARATHQ67C40, MPK7_ORYSJ
Q9LM33, MPK8_ARATHQ5SN53, MPK8_ORYSJQ9LV37, MPK9_ARATH
Q6L5D4, MPK9_ORYSJB0Y4X4, MPKA_ASPFCQ4WQR3, MPKA_ASPFU
B0Y8W7, MPKB_ASPFCA1CAF0, MPKC_ASPCLB0Y462, MPKC_ASPFC
Q4WUN7, MPKC_ASPFUA2QN07, MPKC_ASPNCQ2U469, MPKC_ASPOR
Q0CIC7, MPKC_ASPTNQ9HG11, MPKC_EMENIA1DES4, MPKC_NEOFI
Q06060, MPK_PEAQ40884, MPK_PETHYG4N374, MPS1_PYRO7
O13352, MPS1_PYRORG4N7X0, MST11_PYRO7G4NEB8, MST7_PYRO7
Q8QGV6, NLK2_XENLAB1H3E1, NLK2_XENTRE1BMN8, NLK_BOVIN
A8XSC1, NLK_CAEBRQ9U9Y8, NLK_CAEELE2QWQ2, NLK_CANLF
Q9UBE8, NLK_HUMANO54949, NLK_MOUSED3ZSZ3, NLK_RAT
Q40517, NTF3_TOBACQ40532, NTF4_TOBACQ40531, NTF6_TOBAC
Q17446, PMK1_CAEELG4N0Z0, PMK1_PYRO7Q92246, PMK1_PYROR
Q8MXI4, PMK2_CAEELO44514, PMK3_CAEELB0XR80, SAKA_ASPFC
Q00772, SLT2_YEASTG5EBT1, SMA5_CAEELP41808, SMK1_YEAST
P27638, SPK1_SCHPOQ92398, SPM1_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
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