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ENZYME

ENZYME entry: EC 2.7.8.48

PURL: https://purl.expasy.org/enzyme/EC/2.7.8.48
Accepted Name
ceramide phosphoethanolamine synthase
Alternative Name(s)
CPE synthase
Reaction catalysed
  • CDP-ethanolamine + an N-acyl-sphingoid base = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)
  • an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Comment(s)
  • The enzyme from invertebrates, best studied from the fly Drosophila melanogaster, is common in arthropods, worms, bees, spiders, and scorpions, and has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes.
  • Its product, ceramide phosphoethanolamine, is synthesized as the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca.
  • The invertebrate enzyme requires a Mn(II) cofactor.
  • In mammals the activity has been shown to be catalyzed by members of the EC 2.7.8.27 family, such as SGMS1, SGMS2, and SAMD8.
  • Formerly EC 2.7.8.n3.
Cross-references
BRENDA2.7.8.48
EC2PDB2.7.8.48
ExplorEnz2.7.8.48
KEGG Ligand Database for Enzyme Nomenclature2.7.8.48
IUBMB Enzyme Nomenclature2.7.8.48
MEDLINEFind literature relating to 2.7.8.48
MetaCyc2.7.8.48
Rhea expert-curated reactions2.7.8.48
UniProtKB/Swiss-Prot
O77475, CPESY_DROME

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