ENZYME entry: EC 2.8.1.2

Accepted Name
3-mercaptopyruvate sulfurtransferase.
Reaction catalysed
3-mercaptopyruvate + reduced thioredoxin <=> pyruvate + hydrogen sulfide + oxidized thioredoxin
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes a transsulfuration reaction from 3-mercaptopyruvate to an internal cysteine residue.
  • In the presence of a dithiol such as reduced thioredoxin or dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide.
  • The enzyme participates in a sulfur relay process that leads to the 2-thiolation of some tRNAs and to protein urmylation by transferring sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the MOCS3 sulfurtransferase (EC 2.8.1.11).
Cross-references
PROSITEPDOC00322
BRENDA2.8.1.2
EC2PDB2.8.1.2
ExplorEnz2.8.1.2
PRIAM enzyme-specific profiles2.8.1.2
KEGG Ligand Database for Enzyme Nomenclature2.8.1.2
IUBMB Enzyme Nomenclature2.8.1.2
IntEnz2.8.1.2
MEDLINEFind literature relating to 2.8.1.2
MetaCyc2.8.1.2
UniProtKB/Swiss-Prot
O64530, STR1_ARATH;  Q24JL3, STR2_ARATH;  P58388, THTM_ECO57;  
P31142, THTM_ECOLI;  P25325, THTM_HUMAN;  Q99J99, THTM_MOUSE;  
Q9I452, THTM_PSEAE;  P97532, THTM_RAT;  Q9USJ1, THTM_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
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