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ENZYME entry: EC 3.1.1.109

Accepted Name
iron(III) salmochelin esterase.
Reaction catalysed
  • Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)
  • Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)
  • Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine
  • Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
  • Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine
  • Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine
Comment(s)
  • This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains.
  • The enzyme acts on iron(III)-bound enterobactin and C-glucosylated derivatives known as salmochelins.
  • Unlike EC 3.1.1.107, (IroE), IroD prefers iron(III)-bound siderophores as substrates, and is assumed to act after the iron- siderophore complexes are imported into the cell.
  • It catalyzes several hydrolytic reactions, producing a mixture of iron(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] complex and salmochelin SX.
Cross-references
BRENDA3.1.1.109
EC2PDB3.1.1.109
ExplorEnz3.1.1.109
PRIAM enzyme-specific profiles3.1.1.109
KEGG Ligand Database for Enzyme Nomenclature3.1.1.109
IUBMB Enzyme Nomenclature3.1.1.109
IntEnz3.1.1.109
MEDLINEFind literature relating to 3.1.1.109
MetaCyc3.1.1.109
Rhea expert-curated reactions3.1.1.109
UniProtKB/Swiss-Prot
A0A0H2V660, IROD_ECOL6

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