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ENZYME entry: EC 3.1.1.109

Accepted Name
Iron(III) salmochelin esterase.
Reaction catalysed
  • Iron(III)-[diglucosyl-enterobactin] complex + H(2)O <=> iron(III)-[salmochelin S2] complex
  • Iron(III)-[monoglucosyl-enterobactin] complex + H(2)O <=> iron(III)-[monoglucosyl-(2,3-dihydroxybenzoylserine)(3)] complex
  • Iron(III)-[salmochelin S2] complex + H(2)O <=> iron(III)-[diglucosyl-(2,3-dihydroxybenzoylserine)(2)] complex + N-(2,3-dihydroxybenzoyl)-L-serine
  • Iron(III)-[salmochelin S2] complex + H(2)O <=> iron(III)-[salmochelin S1] complex + salmochelin SX
  • Iron(III)-[monoglucosyl-(2,3-dihydroxybenzoylserine)(3)] complex + H(2)O <=> iron(III)-[salmochelin S1] complex + N-(2,3-dihydroxybenzoyl)-L-serine
  • Iron(III)-[diglucosyl-(2,3-dihydroxybenzoylserine)(2)] complex + H(2)O <=> iron(III)-[salmochelin SX] complex + salmochelin SX
Comment(s)
  • This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains.
  • The enzyme acts on iron(III)-bound enterobactin and C-glucosylated derivatives known as salmochelins.
  • Unlike EC 3.1.1.107, (IroE), IroD prefers iron(III)-bound siderophores as substrates, and is assumed to act after the iron- siderophore complexes are imported into the cell.
  • It catalyzes several hydrolytic reactions, producing a mixture of iron(III)-(N-(2,3-dihydroxybenzoyl)-L-serine) complex and salmochelin SX.
Cross-references
BRENDA3.1.1.109
EC2PDB3.1.1.109
ExplorEnz3.1.1.109
PRIAM enzyme-specific profiles3.1.1.109
KEGG Ligand Database for Enzyme Nomenclature3.1.1.109
IUBMB Enzyme Nomenclature3.1.1.109
IntEnz3.1.1.109
MEDLINEFind literature relating to 3.1.1.109
MetaCyc3.1.1.109
Rhea expert-curated reactions3.1.1.109
UniProtKB/Swiss-Prot
A0A0H2V660, IROD_ECOL6

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