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ENZYME entry: EC

Accepted Name
acyloxyacyl hydrolase.
Reaction catalysed
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
  • The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms.
  • It consists of diglucosamine, beta-D-GlcN-(1->6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue.
  • Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3.
  • The enzyme from human leukocytes detoxifies the lipid by hydrolyzing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS).
  • It also possesses a wide range of phospholipase and acyltransferase activities (e.g. EC, EC, EC and EC, hydrolyzing diacylglycerol and phosphatidyl compounds, but not triacylglycerols.
  • It has a preference for saturated C12-C16 acyl groups.
PRIAM enzyme-specific profiles3.1.1.77
KEGG Ligand Database for Enzyme Nomenclature3.1.1.77
IUBMB Enzyme Nomenclature3.1.1.77
MEDLINEFind literature relating to
Rhea expert-curated reactions3.1.1.77
P28039, AOAH_HUMAN;  O35298, AOAH_MOUSE;  O18823, AOAH_RABIT;  

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