ENZYME entry: EC 3.1.2.29
| Accepted Name |
|---|
| Fluoroacetyl-CoA thioesterase.
|
| Reaction catalysed |
|---|
| Fluoroacetyl-CoA + H(2)O <=> fluoroacetate + CoA |
| Comment(s) |
|---|
- Fluoroacetate is extremely toxic.
- It reacts with CoA to form fluoroacetyl-CoA, which substitutes for
acetyl CoA and reacts with EC 2.3.3.1 to produce fluorocitrate,
a metabolite of which binds very tightly to EC 4.2.1.3 and halts the
TCA cycle.
- This enzyme hydrolyzes fluoroacetyl-CoA before it can react with
citrate synthase, and thus confers fluoroacetate resistance on the
organisms that produce it.
- It has been described in the poisonous plant Dichapetalum cymosum and
the bacterium Streptomyces cattleya, both of which are fluoroacetate
producers.
|
| Cross-references |
|---|
| BRENDA | 3.1.2.29 |
| EC2PDB | 3.1.2.29 |
| ExplorEnz | 3.1.2.29 |
| PRIAM enzyme-specific profiles | 3.1.2.29 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.2.29 |
| IUBMB Enzyme Nomenclature | 3.1.2.29 |
| IntEnz | 3.1.2.29 |
| MEDLINE | Find literature relating to 3.1.2.29 |
| MetaCyc | 3.1.2.29 |
| UniProtKB/Swiss-Prot |
|
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