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ENZYME entry: EC 3.1.2.29

Accepted Name
fluoroacetyl-CoA thioesterase.
Reaction catalysed
fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)
Comment(s)
  • Fluoroacetate is extremely toxic.
  • It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC 2.3.3.1 to produce fluorocitrate, a metabolite of which binds very tightly to EC 4.2.1.3 and halts the TCA cycle.
  • This enzyme hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it.
  • It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers.
Cross-references
BRENDA3.1.2.29
EC2PDB3.1.2.29
ExplorEnz3.1.2.29
PRIAM enzyme-specific profiles3.1.2.29
KEGG Ligand Database for Enzyme Nomenclature3.1.2.29
IUBMB Enzyme Nomenclature3.1.2.29
IntEnz3.1.2.29
MEDLINEFind literature relating to 3.1.2.29
MetaCyc3.1.2.29
Rhea expert-curated reactions3.1.2.29
UniProtKB/Swiss-Prot
Q1EMV2, FLK_STRCT

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