ENZYME entry: EC 3.1.2.29
Accepted Name |
Fluoroacetyl-CoA thioesterase.
|
Reaction catalysed |
Fluoroacetyl-CoA + H(2)O <=> fluoroacetate + CoA |
Comment(s) |
- Fluoroacetate is extremely toxic.
- It reacts with CoA to form fluoroacetyl-CoA, which substitutes for
acetyl CoA and reacts with EC 2.3.3.1 to produce fluorocitrate,
a metabolite of which binds very tightly to EC 4.2.1.3 and halts the
TCA cycle.
- This enzyme hydrolyzes fluoroacetyl-CoA before it can react with
citrate synthase, and thus confers fluoroacetate resistance on the
organisms that produce it.
- It has been described in the poisonous plant Dichapetalum cymosum and
the bacterium Streptomyces cattleya, both of which are fluoroacetate
producers.
|
Cross-references |
BRENDA | 3.1.2.29 |
EC2PDB | 3.1.2.29 |
ExplorEnz | 3.1.2.29 |
PRIAM enzyme-specific profiles | 3.1.2.29 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.2.29 |
IUBMB Enzyme Nomenclature | 3.1.2.29 |
IntEnz | 3.1.2.29 |
MEDLINE | Find literature relating to 3.1.2.29 |
MetaCyc | 3.1.2.29 |
Rhea expert-curated reactions | 3.1.2.29 |
UniProtKB/Swiss-Prot |
|
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