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ENZYME entry: EC 4.2.1.3

Accepted Name
Aconitate hydratase.
Alternative Name(s)
Aconitase.
Cis-aconitase.
Citrate hydro-lyase.
Citrate(isocitrate) hydro-lyase.
Reaction catalysed
Citrate <=> isocitrate
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
  • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
  • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
  • Formerly EC 4.2.1.4.
Cross-references
PROSITEPDOC00423
BRENDA4.2.1.3
EC2PDB4.2.1.3
ExplorEnz4.2.1.3
PRIAM enzyme-specific profiles4.2.1.3
KEGG Ligand Database for Enzyme Nomenclature4.2.1.3
IUBMB Enzyme Nomenclature4.2.1.3
IntEnz4.2.1.3
MEDLINEFind literature relating to 4.2.1.3
MetaCyc4.2.1.3
UniProtKB/Swiss-Prot
P09339, ACNA_BACSU;  P70920, ACNA_BRADU;  Q6NH63, ACNA_CORDI;  
Q8FTA8, ACNA_COREF;  Q8NQ98, ACNA_CORGL;  Q4JVM4, ACNA_CORJK;  
Q937N8, ACNA_CUPNE;  Q9RTN7, ACNA_DEIRA;  P25516, ACNA_ECOLI;  
Q2A1K3, ACNA_FRATH;  O08451, ACNA_MYCAV;  A0QX20, ACNA_MYCS2;  
O53166, ACNA_MYCTU;  Q9I3F5, ACNA_PSEAE;  Q1RKD5, ACNA_RICBR;  
Q92G90, ACNA_RICCN;  Q4UK20, ACNA_RICFE;  Q9ZCF4, ACNA_RICPR;  
Q68VV0, ACNA_RICTY;  Q8ZP52, ACNA_SALTY;  Q5HG69, ACNA_STAAC;  
P63433, ACNA_STAAM;  P99148, ACNA_STAAN;  Q6GH55, ACNA_STAAR;  
Q6G9K9, ACNA_STAAS;  P63434, ACNA_STAAW;  Q5HPJ0, ACNA_STAEQ;  
Q8CPC2, ACNA_STAES;  Q59938, ACNA_STRMU;  Q5SMF6, ACNA_THET8;  
P36683, ACNB_ECOLI;  Q9ZL64, ACNB_HELPJ;  P56418, ACNB_HELPY;  
Q9I2V5, ACNB_PSEAE;  Q8ZRS8, ACNB_SALTY;  P74582, ACNB_SYNY3;  
Q8EJW3, ACND_SHEON;  Q42560, ACO1_ARATH;  Q94A28, ACO2M_ARATH;  
Q9SIB9, ACO3M_ARATH;  Q0VCU1, ACOC_BOVIN;  Q23500, ACOC_CAEEL;  
Q90875, ACOC_CHICK;  P49608, ACOC_CUCMA;  Q42669, ACOC_CUCMC;  
Q54X73, ACOC_DICDI;  P21399, ACOC_HUMAN;  P28271, ACOC_MOUSE;  
Q6YZX6, ACOC_ORYSJ;  Q01059, ACOC_RABIT;  Q63270, ACOC_RAT;  
O04916, ACOC_SOLTU;  D4AT77, ACON_ARTBC;  Q4WLN1, ACON_ASPFU;  
P20004, ACON_BOVIN;  P34455, ACON_CAEEL;  P82611, ACON_CANAL;  
Q54XS2, ACON_DICDI;  C8VG90, ACON_EMENI;  P49609, ACON_GRAGA;  
Q99798, ACON_HUMAN;  P37032, ACON_LEGPH;  Q99KI0, ACON_MOUSE;  
P16276, ACON_PIG;  Q9ER34, ACON_RAT;  O13966, ACON_SCHPO;  
P19414, ACON_YEAST;  Q8NSL3, PRPD2_CORGL;  Q937N6, PRPD_CUPNE;  
Q8X693, PRPD_ECO57;  P77243, PRPD_ECOLI;  H8F0D6, PRPD_MYCTE;  
O06582, PRPD_MYCTU;  Q8Z903, PRPD_SALTI;  P74840, PRPD_SALTY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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