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ENZYME entry: EC 3.1.21.5

Accepted Name
type III site-specific deoxyribonuclease.
Alternative Name(s)
type III restriction enzyme.
Reaction catalysed
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates
Comment(s)
  • Has an absolute requirement for ATP, but does not hydrolyze it; S-adenosyl-L-methionine stimulates the reaction, but is not absolutely required.
  • Recognize specific short DNA sequences and cleave a short distance away from the recognition sequence.
  • Exist as complexes with enzymes of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
  • Formerly EC 3.1.24.3 and EC 3.1.24.4.
Cross-references
BRENDA3.1.21.5
EC2PDB3.1.21.5
ExplorEnz3.1.21.5
PRIAM enzyme-specific profiles3.1.21.5
KEGG Ligand Database for Enzyme Nomenclature3.1.21.5
IUBMB Enzyme Nomenclature3.1.21.5
IntEnz3.1.21.5
MEDLINEFind literature relating to 3.1.21.5
MetaCyc3.1.21.5
Rhea expert-curated reactions3.1.21.5
UniProtKB/Swiss-Prot
P25241, T3RE_BACC1;  P08764, T3RE_BPP1;  Q5ZND2, T3RE_ECOLX;  
P40815, T3RE_SALTY;  P44105, T3RH_HAEIN;  

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