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ENZYME

ENZYME entry: EC 3.1.26.13

Accepted Name
retroviral ribonuclease H
Reaction catalysed
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus
Comment(s)
  • Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication.
  • To perform this task the enzyme combines two distinct activities.
  • The polymerase domain (EC 2.7.7.49) occupies the N-terminal two- thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third.
  • The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites.
Cross-references
BRENDA3.1.26.13
EC2PDB3.1.26.13
ExplorEnz3.1.26.13
PRIAM enzyme-specific profiles3.1.26.13
KEGG Ligand Database for Enzyme Nomenclature3.1.26.13
IUBMB Enzyme Nomenclature3.1.26.13
IntEnz3.1.26.13
MEDLINEFind literature relating to 3.1.26.13
MetaCyc3.1.26.13
Rhea expert-curated reactions3.1.26.13
UniProtKB/Swiss-Prot
P19560, POL_BIV29P33459, POL_CAEVCP11204, POL_EIAV9
P32542, POL_EIAVCP03371, POL_EIAVYP16088, POL_FIVPE
P19028, POL_FIVSDP31822, POL_FIVT2O93215, POL_HV190
O12158, POL_HV192O89290, POL_HV193Q9QBY3, POL_HV196
Q9QBZ9, POL_HV197O41798, POL_HV19NP03369, POL_HV1A2
Q77373, POL_HV1ANP03366, POL_HV1B1P04587, POL_HV1B5
Q73368, POL_HV1B9P03367, POL_HV1BRP04589, POL_HV1EL
Q75002, POL_HV1ETP04585, POL_HV1H2P20875, POL_HV1JR
P0C6F2, POL_HV1LWQ9QBZ1, POL_HV1M2P04588, POL_HV1MA
P05961, POL_HV1MNQ9QBZ5, POL_HV1MPQ79666, POL_HV1MV
P12497, POL_HV1N5P18802, POL_HV1NDP20892, POL_HV1OY
P05959, POL_HV1RHQ9WC54, POL_HV1S2Q9WC63, POL_HV1S9
O89940, POL_HV1SEP24740, POL_HV1U4Q9Q720, POL_HV1V9
Q9QSR3, POL_HV1VIP35963, POL_HV1Y2Q9IDV9, POL_HV1YB
O91080, POL_HV1YFP12499, POL_HV1Z2P18096, POL_HV2BE
P24107, POL_HV2CAP17757, POL_HV2D1P15833, POL_HV2D2
Q89928, POL_HV2EHP18042, POL_HV2G1Q74120, POL_HV2KR
P05962, POL_HV2NZP04584, POL_HV2ROP12451, POL_HV2SB
P20876, POL_HV2STQ76634, POL_HV2UCQ82851, POL_JEMBR
P16901, POL_OMVVSP17283, POL_SIVCZQ1A249, POL_SIVEK
Q02836, POL_SIVG1P22382, POL_SIVGBP05896, POL_SIVM1
Q1A267, POL_SIVMBP05897, POL_SIVMKP12502, POL_SIVS4
P19505, POL_SIVSPQ8AII1, POL_SIVTNP27973, POL_SIVV1
P27980, POL_SIVVGP05895, POL_SIVVT

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