ENZYME entry: EC 3.1.26.13

Accepted Name

retroviral ribonuclease H

Reaction catalysed

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus

Comment(s)

Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication.
To perform this task the enzyme combines two distinct activities.
The polymerase domain (EC 2.7.7.49) occupies the N-terminal two- thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third.
The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites.

Cross-references

BRENDA

3.1.26.13

EC2PDB

3.1.26.13

ExplorEnz

3.1.26.13

PRIAM enzyme-specific profiles

3.1.26.13

KEGG Ligand Database for Enzyme Nomenclature

3.1.26.13

IUBMB Enzyme Nomenclature

3.1.26.13

IntEnz

3.1.26.13

MEDLINE

Find literature relating to 3.1.26.13

MetaCyc

3.1.26.13

Rhea expert-curated reactions

3.1.26.13

UniProtKB/Swiss-Prot

P19560, POL_BIV29	P33459, POL_CAEVC	P11204, POL_EIAV9
P32542, POL_EIAVC	P03371, POL_EIAVY	P16088, POL_FIVPE
P19028, POL_FIVSD	P31822, POL_FIVT2	O93215, POL_HV190
O12158, POL_HV192	O89290, POL_HV193	Q9QBY3, POL_HV196
Q9QBZ9, POL_HV197	O41798, POL_HV19N	P03369, POL_HV1A2
Q77373, POL_HV1AN	P03366, POL_HV1B1	P04587, POL_HV1B5
Q73368, POL_HV1B9	P03367, POL_HV1BR	P04589, POL_HV1EL
Q75002, POL_HV1ET	P04585, POL_HV1H2	P20875, POL_HV1JR
P0C6F2, POL_HV1LW	Q9QBZ1, POL_HV1M2	P04588, POL_HV1MA
P05961, POL_HV1MN	Q9QBZ5, POL_HV1MP	Q79666, POL_HV1MV
P12497, POL_HV1N5	P18802, POL_HV1ND	P20892, POL_HV1OY
P05959, POL_HV1RH	Q9WC54, POL_HV1S2	Q9WC63, POL_HV1S9
O89940, POL_HV1SE	P24740, POL_HV1U4	Q9Q720, POL_HV1V9
Q9QSR3, POL_HV1VI	P35963, POL_HV1Y2	Q9IDV9, POL_HV1YB
O91080, POL_HV1YF	P12499, POL_HV1Z2	P18096, POL_HV2BE
P24107, POL_HV2CA	P17757, POL_HV2D1	P15833, POL_HV2D2
Q89928, POL_HV2EH	P18042, POL_HV2G1	Q74120, POL_HV2KR
P05962, POL_HV2NZ	P04584, POL_HV2RO	P12451, POL_HV2SB
P20876, POL_HV2ST	Q76634, POL_HV2UC	Q82851, POL_JEMBR
P16901, POL_OMVVS	P17283, POL_SIVCZ	Q1A249, POL_SIVEK
Q02836, POL_SIVG1	P22382, POL_SIVGB	P05896, POL_SIVM1
Q1A267, POL_SIVMB	P05897, POL_SIVMK	P12502, POL_SIVS4
P19505, POL_SIVSP	Q8AII1, POL_SIVTN	P27973, POL_SIVV1
P27980, POL_SIVVG	P05895, POL_SIVVT

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