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ENZYME

ENZYME entry: EC 3.1.3.62

Accepted Name
multiple inositol-polyphosphate phosphatase
Alternative Name(s)
MIPP
phytase
Reaction catalysed
  • 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
  • 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate
  • 1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate
  • 1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate
  • 1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate
Comment(s)
  • This ubiquitous enzyme degrades myo-inositol hexakisphosphate (phytate) to Ins(2,3)P2 and Ins(2)P.
  • Activities have been characterized in the yeast Saccharomyces cerevisiae, the plant Lupinus albus and the bacteria Bacillus sp. and Raoultella terrigena.
  • In mammal cells Ins(2,3)P2 and Ins(2)P are the major inositol phosphate compounds found.
  • The mammal enzyme is also active on Ins(1,3,4,5,6)P5 that is dephosphorylated to Ins(1,4,5,6)P4 and Ins(1,4,5)P3, and on 2,3- bisphospho-D-glycerate (cf. EC 3.1.3.80).
  • In addition, it acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3 in vitro (cf. EC 3.1.3.67).
  • It does not hydrolyze phosphates from the 2-positions of inositol phosphates.
  • In other organisms the degradation of phytate follows different routes. (cf. EC 3.1.3.8, EC 3.1.3.26, and EC 3.1.3.72).
Cross-references
BRENDA3.1.3.62
EC2PDB3.1.3.62
ExplorEnz3.1.3.62
PRIAM enzyme-specific profiles3.1.3.62
KEGG Ligand Database for Enzyme Nomenclature3.1.3.62
IUBMB Enzyme Nomenclature3.1.3.62
IntEnz3.1.3.62
MEDLINEFind literature relating to 3.1.3.62
MetaCyc3.1.3.62
Rhea expert-curated reactions3.1.3.62
UniProtKB/Swiss-Prot
F1NPQ2, MINP1_CHICKQ54ND5, MINP1_DICDIQ9VV72, MINP1_DROME
Q9UNW1, MINP1_HUMANQ9Z2L6, MINP1_MOUSEQ5R890, MINP1_PONAB
O35217, MINP1_RAT

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