ENZYME entry: EC 3.1.4.50
| Accepted Name |
|---|
| glycosylphosphatidylinositol phospholipase D.
|
| Alternative Name(s) |
|---|
| glycoprotein phospholipase D. |
| GPI-PLD. |
| phosphatidylinositol-glycan-specific phospholipase D. |
| phosphatidylinositol phospholipase D. |
| phosphatidylinositol-specific phospholipase D. |
| Reaction catalysed |
|---|
| an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) |
| Comment(s) |
|---|
- This enzyme is also active when O-4 of the glucosamine is substituted
by carrying the oligosaccharide that can link a protein to the
structure.
- It therefore cleaves proteins from the lipid part of the
glycosylphosphatidylinositol (GPI) anchors, but does so by
hydrolysis, whereas EC 4.6.1.14 does so by elimination.
- It acts on plasma membranes only after solubilization of the
substrate with detergents or solvents, but it may act on
intracellular membranes.
|
| Cross-references |
|---|
| BRENDA | 3.1.4.50 |
| EC2PDB | 3.1.4.50 |
| ExplorEnz | 3.1.4.50 |
| PRIAM enzyme-specific profiles | 3.1.4.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.50 |
| IUBMB Enzyme Nomenclature | 3.1.4.50 |
| IntEnz | 3.1.4.50 |
| MEDLINE | Find literature relating to 3.1.4.50 |
| MetaCyc | 3.1.4.50 |
| Rhea expert-curated reactions | 3.1.4.50 |
| UniProtKB/Swiss-Prot |
|
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