ENZYME entry: EC 3.1.4.50
| Accepted Name |
|---|
| Glycosylphosphatidylinositol phospholipase D.
|
| Alternative Name(s) |
|---|
| Glycoprotein phospholipase D. |
| GPI-PLD. |
| Phosphatidylinositol phospholipase D. |
| Phosphatidylinositol-glycan-specific phospholipase D. |
| Phosphatidylinositol-specific phospholipase D. |
| Reaction catalysed |
|---|
| 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate |
| Comment(s) |
|---|
- This enzyme is also active when O-4 of the glucosamine is substituted
by carrying the oligosaccharide that can link a protein to the
structure.
- It therefore cleaves proteins from the lipid part of the
glycosylphosphatidylinositol (GPI) anchors, but does so by
hydrolysis, whereas EC 4.6.1.14 does so by elimination.
- It acts on plasma membranes only after solubilization of the
substrate with detergents or solvents, but it may act on
intracellular membranes.
|
| Cross-references |
|---|
| BRENDA | 3.1.4.50 |
| EC2PDB | 3.1.4.50 |
| ExplorEnz | 3.1.4.50 |
| PRIAM enzyme-specific profiles | 3.1.4.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.50 |
| IUBMB Enzyme Nomenclature | 3.1.4.50 |
| IntEnz | 3.1.4.50 |
| MEDLINE | Find literature relating to 3.1.4.50 |
| MetaCyc | 3.1.4.50 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-