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ENZYME entry: EC 3.1.4.50

Accepted Name
Glycosylphosphatidylinositol phospholipase D.
Alternative Name(s)
Glycoprotein phospholipase D.
GPI-PLD.
Phosphatidylinositol phospholipase D.
Phosphatidylinositol-glycan-specific phospholipase D.
Phosphatidylinositol-specific phospholipase D.
Reaction catalysed
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate
Comment(s)
  • This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure.
  • It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas EC 4.6.1.14 does so by elimination.
  • It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
Cross-references
BRENDA3.1.4.50
EC2PDB3.1.4.50
ExplorEnz3.1.4.50
PRIAM enzyme-specific profiles3.1.4.50
KEGG Ligand Database for Enzyme Nomenclature3.1.4.50
IUBMB Enzyme Nomenclature3.1.4.50
IntEnz3.1.4.50
MEDLINEFind literature relating to 3.1.4.50
MetaCyc3.1.4.50
Rhea expert-curated reactions3.1.4.50
UniProtKB/Swiss-Prot
P80109, PHLD_BOVIN;  P80108, PHLD_HUMAN;  O70362, PHLD_MOUSE;  
Q8R2H5, PHLD_RAT;  Q86AV9, PLDG_DICDI;  

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