ENZYME entry: EC 3.1.4.50
Accepted Name |
Glycosylphosphatidylinositol phospholipase D.
|
Alternative Name(s) |
Glycoprotein phospholipase D. |
GPI-PLD. |
Phosphatidylinositol phospholipase D. |
Phosphatidylinositol-glycan-specific phospholipase D. |
Phosphatidylinositol-specific phospholipase D. |
Reaction catalysed |
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate |
Comment(s) |
- This enzyme is also active when O-4 of the glucosamine is substituted
by carrying the oligosaccharide that can link a protein to the
structure.
- It therefore cleaves proteins from the lipid part of the
glycosylphosphatidylinositol (GPI) anchors, but does so by
hydrolysis, whereas EC 4.6.1.14 does so by elimination.
- It acts on plasma membranes only after solubilization of the
substrate with detergents or solvents, but it may act on
intracellular membranes.
|
Cross-references |
BRENDA | 3.1.4.50 |
EC2PDB | 3.1.4.50 |
ExplorEnz | 3.1.4.50 |
PRIAM enzyme-specific profiles | 3.1.4.50 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.50 |
IUBMB Enzyme Nomenclature | 3.1.4.50 |
IntEnz | 3.1.4.50 |
MEDLINE | Find literature relating to 3.1.4.50 |
MetaCyc | 3.1.4.50 |
UniProtKB/Swiss-Prot |
|
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