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ENZYME

ENZYME entry: EC 4.6.1.14

PURL: https://purl.expasy.org/enzyme/EC/4.6.1.14
Accepted Name
glycosylphosphatidylinositol diacylglycerol-lyase
Alternative Name(s)
(glycosyl)phosphatidylinositol-specific phospholipase C
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol- lyase (1,2-cyclic-phosphate-forming)
glycosyl inositol phospholipid anchor-hydrolyzing enzyme
glycosylphosphatidylinositol-phospholipase C
glycosylphosphatidylinositol-specific phospholipase C
GPI-PLC
GPI-specific phospholipase C
variant-surface-glycoprotein phospholipase C
VSG-lipase
Reaction catalysed
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol
Comment(s)
  • This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure.
  • It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors.
  • In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group.
  • In other cases, the diacylglycerol is replaced by ceramide.
  • The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown.
  • Substitution on O-2 of the inositol blocks action of this enzyme.
  • It is not identical with EC 3.1.4.50.
  • Formerly EC 3.1.4.47.
Cross-references
BRENDA4.6.1.14
EC2PDB4.6.1.14
ExplorEnz4.6.1.14
KEGG Ligand Database for Enzyme Nomenclature4.6.1.14
IUBMB Enzyme Nomenclature4.6.1.14
MEDLINEFind literature relating to 4.6.1.14
MetaCyc4.6.1.14
Rhea expert-curated reactions4.6.1.14
UniProtKB/Swiss-Prot
P09194, PHLC_TRYBBO15886, PHLC_TRYCR

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