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ENZYME entry: EC 3.1.4.53

Accepted Name
3',5'-cyclic-AMP phosphodiesterase.
Alternative Name(s)
cAMP-specific PDE.
cAMP-specific phosphodiesterase.
Reaction catalysed
3',5'-cyclic AMP + H2O <=> AMP + H(+)
Comment(s)
  • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
  • Formerly EC 3.1.4.n1.
Cross-references
BRENDA3.1.4.53
EC2PDB3.1.4.53
ExplorEnz3.1.4.53
PRIAM enzyme-specific profiles3.1.4.53
KEGG Ligand Database for Enzyme Nomenclature3.1.4.53
IUBMB Enzyme Nomenclature3.1.4.53
IntEnz3.1.4.53
MEDLINEFind literature relating to 3.1.4.53
MetaCyc3.1.4.53
Rhea expert-curated reactions3.1.4.53
UniProtKB/Swiss-Prot
D4P095, CNPD3_PSEAI;  P0AEW5, CPDA_ECO57;  P0AEW4, CPDA_ECOLI;  
P44685, CPDA_HAEIN;  Q8DEI1, CPDA_VIBVU;  Q9VJ79, PDE11_DROME;  
Q9HCR9, PDE11_HUMAN;  P0C1Q2, PDE11_MOUSE;  Q8VID6, PDE11_RAT;  
Q1KKS3, PDE11_TAKRU;  P12019, PDE1_DICDI;  Q23917, PDE2_DICDI;  
P06776, PDE2_YEAST;  O89085, PDE4A_CAVPO;  Q9W4T4, PDE4A_DROME;  
P27815, PDE4A_HUMAN;  O89084, PDE4A_MOUSE;  P54748, PDE4A_RAT;  
P12252, PDE4B_DROME;  Q07343, PDE4B_HUMAN;  P14646, PDE4B_RAT;  
Q9W4S9, PDE4C_DROME;  Q08493, PDE4C_HUMAN;  Q3UEI1, PDE4C_MOUSE;  
P14644, PDE4C_RAT;  Q08499, PDE4D_HUMAN;  Q01063, PDE4D_MOUSE;  
P14270, PDE4D_RAT;  Q8IRU4, PDE4E_DROME;  Q86H13, PDE4_DICDI;  
Q8MM62, PDE6_DICDI;  Q13946, PDE7A_HUMAN;  P70453, PDE7A_MOUSE;  
O08593, PDE7A_RAT;  Q9NP56, PDE7B_HUMAN;  Q9QXQ1, PDE7B_MOUSE;  
Q54HY0, PDE7_DICDI;  O60658, PDE8A_HUMAN;  O88502, PDE8A_MOUSE;  
O95263, PDE8B_HUMAN;  E9Q4S1, PDE8B_MOUSE;  Q6NNF2, PDE8_DROME;  
Q8I6Z7, PDEB_PLAF7;  

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