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ENZYME

ENZYME entry: EC 3.1.4.53

Accepted Name
3',5'-cyclic-AMP phosphodiesterase
Alternative Name(s)
cAMP-specific PDE
cAMP-specific phosphodiesterase
Reaction catalysed
3',5'-cyclic AMP + H2O <=> AMP + H(+)
Comment(s)
  • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
  • Formerly EC 3.1.4.n1.
Cross-references
BRENDA3.1.4.53
EC2PDB3.1.4.53
ExplorEnz3.1.4.53
PRIAM enzyme-specific profiles3.1.4.53
KEGG Ligand Database for Enzyme Nomenclature3.1.4.53
IUBMB Enzyme Nomenclature3.1.4.53
IntEnz3.1.4.53
MEDLINEFind literature relating to 3.1.4.53
MetaCyc3.1.4.53
Rhea expert-curated reactions3.1.4.53
UniProtKB/Swiss-Prot
D4P095, CNPD3_PSEAIP0AEW5, CPDA_ECO57P0AEW4, CPDA_ECOLI
P44685, CPDA_HAEINQ8DEI1, CPDA_VIBVUQ9VJ79, PDE11_DROME
Q9HCR9, PDE11_HUMANP0C1Q2, PDE11_MOUSEQ8VID6, PDE11_RAT
Q1KKS3, PDE11_TAKRUP12019, PDE1_DICDIQ23917, PDE2_DICDI
P06776, PDE2_YEASTO89085, PDE4A_CAVPOQ9W4T4, PDE4A_DROME
P27815, PDE4A_HUMANO89084, PDE4A_MOUSEP54748, PDE4A_RAT
P12252, PDE4B_DROMEQ07343, PDE4B_HUMANP14646, PDE4B_RAT
Q9W4S9, PDE4C_DROMEQ08493, PDE4C_HUMANQ3UEI1, PDE4C_MOUSE
P14644, PDE4C_RATQ08499, PDE4D_HUMANQ01063, PDE4D_MOUSE
P14270, PDE4D_RATQ8IRU4, PDE4E_DROMEQ86H13, PDE4_DICDI
Q8MM62, PDE6_DICDIQ13946, PDE7A_HUMANP70453, PDE7A_MOUSE
O08593, PDE7A_RATQ9NP56, PDE7B_HUMANQ9QXQ1, PDE7B_MOUSE
Q54HY0, PDE7_DICDIO60658, PDE8A_HUMANO88502, PDE8A_MOUSE
O95263, PDE8B_HUMANE9Q4S1, PDE8B_MOUSEQ6NNF2, PDE8_DROME
Q8I6Z7, PDEB_PLAF7

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-