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ENZYME entry: EC 3.1.4.60

Accepted Name
PApA phosphodiesterase.
Alternative Name(s)
PApA hydrolase.
Reaction catalysed
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(2)O <=> 2 AMP
Comment(s)
  • The enzyme, characterized from the Gram-positive bacterium Staphylococcus aureus, is a cytoplasmic protein that contains a DHH/DHHA1 domain.
  • It can act on cyclic di-3',5'-adenylate with a much lower activity (cf. EC 3.1.4.59).
  • Activity requires Mn(2+) and is inhibited by ppGpp.
Cross-references
BRENDA3.1.4.60
EC2PDB3.1.4.60
ExplorEnz3.1.4.60
PRIAM enzyme-specific profiles3.1.4.60
KEGG Ligand Database for Enzyme Nomenclature3.1.4.60
IUBMB Enzyme Nomenclature3.1.4.60
IntEnz3.1.4.60
MEDLINEFind literature relating to 3.1.4.60
MetaCyc3.1.4.60

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