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ENZYME

ENZYME entry: EC 3.1.4.60

PURL: https://purl.expasy.org/enzyme/EC/3.1.4.60
Accepted Name
pApA phosphodiesterase
Alternative Name(s)
pApA hydrolase
Reaction catalysed
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)
Comment(s)
  • The enzyme, characterized from the Gram-positive bacterium Staphylococcus aureus, is a cytoplasmic protein that contains a DHH/DHHA1 domain.
  • It can act on cyclic di-3',5'-adenylate with a much lower activity (cf. EC 3.1.4.59).
  • Activity requires Mn(2+) and is inhibited by ppGpp.
Cross-references
BRENDA3.1.4.60
EC2PDB3.1.4.60
ExplorEnz3.1.4.60
KEGG Ligand Database for Enzyme Nomenclature3.1.4.60
IUBMB Enzyme Nomenclature3.1.4.60
MEDLINEFind literature relating to 3.1.4.60
MetaCyc3.1.4.60
Rhea expert-curated reactions3.1.4.60

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-