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ENZYME entry: EC

Accepted Name
linear primary-alkylsulfatase.
Alternative Name(s)
type III linear primary-alkylsulfatase.
Reaction catalysed
a primary linear alkyl sulfate ester + H2O <=> a primary alcohol + H(+) + sulfate
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • This enzyme belongs to the type III sulfatase family.
  • The enzyme is active against linear primary-alkyl sulfate esters, such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl sulfate.
  • The enzyme from Pseudomonas aeruginosa is secreted out of the cell.
  • The catalytic mechanism begins with activation of a water molecule by the binuclear Zn(2+) cluster, resulting in a nucleophilic attack on the carbon atom.
  • Cf. EC and EC
PRIAM enzyme-specific profiles3.1.6.21
KEGG Ligand Database for Enzyme Nomenclature3.1.6.21
IUBMB Enzyme Nomenclature3.1.6.21
MEDLINEFind literature relating to
Rhea expert-curated reactions3.1.6.21

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