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ENZYME entry: EC 3.1.6.21

Accepted Name
Linear primary-alkylsulfatase.
Alternative Name(s)
Type III linear primary-alkylsulfatase.
Reaction catalysed
A primary alkyl sulfate ester + H(2)O <=> an alcohol + sulfate
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • This enzyme belongs to the type III sulfatase family.
  • The enzyme is active against linear primary-alkyl sulfate esters, such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl sulfate.
  • The enzyme from Pseudomonas aeruginosa is secreted out of the cell.
  • The catalytic mechanism begins with activation of a water molecule by the binuclear Zn(2+) cluster, resulting in a nucleophilic attack on the carbon atom.
  • Cf. EC 3.1.6.22 and EC 3.1.6.19.
Cross-references
BRENDA3.1.6.21
EC2PDB3.1.6.21
ExplorEnz3.1.6.21
PRIAM enzyme-specific profiles3.1.6.21
KEGG Ligand Database for Enzyme Nomenclature3.1.6.21
IUBMB Enzyme Nomenclature3.1.6.21
IntEnz3.1.6.21
MEDLINEFind literature relating to 3.1.6.21
MetaCyc3.1.6.21
Rhea expert-curated reactions3.1.6.21
UniProtKB/Swiss-Prot
P32717, LPAKS_ECOLI;  Q9I5I9, LPAKS_PSEAE;  Q52556, LPAKS_PSES9;  
F2WP51, LPAKS_PSESP;  

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