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ENZYME

ENZYME entry: EC 3.1.6.19

Accepted Name
(R)-specific secondary-alkylsulfatase (type III)
Alternative Name(s)
(R)-specific sec-alkylsulfatase
(R)-specific secondary-alkylsulfatase
sec-alkylsulfatase
Reaction catalysed
an (R)-secondary-alkyl sulfate + H2O = an (S)-secondary-alcohol + sulfate
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • This enzyme belongs to the type III sulfatase family.
  • The enzyme from the bacterium Rhodococcus ruber prefers linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates.
  • The enzyme from the bacterium Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties.
  • Hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom, resulting in perfect enantioselectivity. cf. EC 1.14.11.77 and EC 3.1.6.1.
Cross-references
BRENDA3.1.6.19
EC2PDB3.1.6.19
ExplorEnz3.1.6.19
PRIAM enzyme-specific profiles3.1.6.19
KEGG Ligand Database for Enzyme Nomenclature3.1.6.19
IUBMB Enzyme Nomenclature3.1.6.19
IntEnz3.1.6.19
MEDLINEFind literature relating to 3.1.6.19
MetaCyc3.1.6.19
Rhea expert-curated reactions3.1.6.19
UniProtKB/Swiss-Prot
F8KAY7, RSAKS_PSESP

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