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ENZYME entry: EC 3.1.6.19

Accepted Name
(R)-specific secondary-alkylsulfatase.
Alternative Name(s)
(R)-specific sec-alkylsulfatase.
Sec-alkylsulfatase.
Reaction catalysed
An (R)-secondary-alkyl sulfate + H(2)O <=> an (S)-secondary-alcohol + sulfate
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme from Rhodococcus ruber is involved in the biodegradation of alkyl sulfate esters used as detergents and released into the environment.
  • The preferred substrates are linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates.
  • The enzyme from Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties.
  • Perfect enantioselectivities are obtained for substrates bearing groups of different size adjacent to the sulfate moiety.
  • The enzymatic hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom.
Cross-references
BRENDA3.1.6.19
EC2PDB3.1.6.19
ExplorEnz3.1.6.19
PRIAM enzyme-specific profiles3.1.6.19
KEGG Ligand Database for Enzyme Nomenclature3.1.6.19
IUBMB Enzyme Nomenclature3.1.6.19
IntEnz3.1.6.19
MEDLINEFind literature relating to 3.1.6.19
MetaCyc3.1.6.19
Rhea expert-curated reactions3.1.6.19

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