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ENZYME

ENZYME entry: EC 3.2.1.10

Accepted Name
oligo-1,6-glucosidase
Alternative Name(s)
alpha-methylglucosidase
isomaltase
oligosaccharide alpha-1,6-glucosidase
sucrase-isomaltase
Reaction catalysed
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose
Comment(s)
  • This enzyme, like EC 3.2.1.33, can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41, EC 3.2.1.142 and EC 3.2.1.68 is maltose.
  • It also hydrolyzes isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin.
  • The enzyme from intestinal mucosa is a single polypeptide chain that also catalyzes the reaction of EC 3.2.1.48.
  • Differs from EC 3.2.1.33 in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.
Cross-references
BRENDA3.2.1.10
EC2PDB3.2.1.10
ExplorEnz3.2.1.10
PRIAM enzyme-specific profiles3.2.1.10
KEGG Ligand Database for Enzyme Nomenclature3.2.1.10
IUBMB Enzyme Nomenclature3.2.1.10
IntEnz3.2.1.10
MEDLINEFind literature relating to 3.2.1.10
MetaCyc3.2.1.10
Rhea expert-curated reactions3.2.1.10
UniProtKB/Swiss-Prot
Q08295, IMA2_YEASTP40884, IMA5_YEASTP0CW40, MALX2_YEAST
P53051, MALX3_YEASTP0CW41, MALX4_YEASTO06994, O16G1_BACSU
O34364, O16G2_BACSUO05242, O16G3_BACSUP21332, O16G_BACCE
P29093, O16G_BACF5Q9K8U9, O16G_HALH5Q45101, O16G_HEYCO
P29094, O16G_PARTMP14410, SUIS_HUMANP56729, SUIS_PIG
P07768, SUIS_RABITP23739, SUIS_RATO62653, SUIS_SUNMU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
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