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ENZYME entry: EC

Accepted Name
endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase
Reaction catalysed
H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)
  • In yeast this activity is catalyzed by a dedicated enzyme that processes unfolded protein-bound Man8GlcNAc2 N-glycans within the endoplasmic reticulum to Man7GlcNAc2.
  • The exposed alpha-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation.
  • In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation.
  • It is carried out by EC
  • The names of the isomers listed here are based on a nomenclature system proposed by Prien et al.
PRIAM enzyme-specific profiles3.2.1.210
KEGG Ligand Database for Enzyme Nomenclature3.2.1.210
IUBMB Enzyme Nomenclature3.2.1.210
MEDLINEFind literature relating to
Rhea expert-curated reactions3.2.1.210

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