ENZYME entry: EC 3.2.1.210
| Accepted Name |
|---|
| Endoplasmic reticulum Man(8)GlcNAc(2) 1,2-alpha-mannosidase.
|
| Reaction catalysed |
|---|
| Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + H(2)O <=> Man(7)GlcNAc(2)-[protein] (isomer 7A(1,2,3)B(3)) + D-mannopyranose |
| Comment(s) |
|---|
- In yeast this activity is catalyzed by a dedicated enzyme that
processes unfolded protein-bound Man(8)GlcNAc(2) N-glycans within the
endoplasmic reticulum to Man(7)GlcNAc(2).
- The exposed alpha-1,6-linked mannose residue in the product enables
the recognition by the YOS9 lectin, targeting the proteins for
degradation.
- In mammalian cells this activity is part of the regular processing of
N-glycosylated proteins, and is not associated with protein
degradation.
- It is carried out by EC 3.2.1.113.
- The names of the isomers listed here are based on a nomenclature
system proposed by Prien et al.
|
| Cross-references |
|---|
| BRENDA | 3.2.1.210 |
| EC2PDB | 3.2.1.210 |
| ExplorEnz | 3.2.1.210 |
| PRIAM enzyme-specific profiles | 3.2.1.210 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.210 |
| IUBMB Enzyme Nomenclature | 3.2.1.210 |
| IntEnz | 3.2.1.210 |
| MEDLINE | Find literature relating to 3.2.1.210 |
| MetaCyc | 3.2.1.210 |
| Rhea expert-curated reactions | 3.2.1.210 |
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