ENZYME entry: EC 220.127.116.11
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|Endoplasmic reticulum Man(8)GlcNAc(2) 1,2-alpha-mannosidase.
|Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + H(2)O <=> Man(7)GlcNAc(2)-[protein] (isomer 7A(1,2,3)B(3)) + D-mannopyranose|
- In yeast this activity is catalyzed by a dedicated enzyme that
processes unfolded protein-bound Man(8)GlcNAc(2) N-glycans within the
endoplasmic reticulum to Man(7)GlcNAc(2).
- The exposed alpha-1,6-linked mannose residue in the product enables
the recognition by the YOS9 lectin, targeting the proteins for
- In mammalian cells this activity is part of the regular processing of
N-glycosylated proteins, and is not associated with protein
- It is carried out by EC 18.104.22.168.
- The names of the isomers listed here are based on a nomenclature
system proposed by Prien et al.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
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