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ENZYME entry: EC

Accepted Name
Endoplasmic reticulum Man(8)GlcNAc(2) 1,2-alpha-mannosidase.
Reaction catalysed
Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + H(2)O <=> Man(7)GlcNAc(2)-[protein] (isomer 7A(1,2,3)B(3)) + D-mannopyranose
  • In yeast this activity is catalyzed by a dedicated enzyme that processes unfolded protein-bound Man(8)GlcNAc(2) N-glycans within the endoplasmic reticulum to Man(7)GlcNAc(2).
  • The exposed alpha-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation.
  • In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation.
  • It is carried out by EC
  • The names of the isomers listed here are based on a nomenclature system proposed by Prien et al.
PRIAM enzyme-specific profiles3.2.1.210
KEGG Ligand Database for Enzyme Nomenclature3.2.1.210
IUBMB Enzyme Nomenclature3.2.1.210
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