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ENZYME

ENZYME entry: EC 3.2.1.217

Accepted Name
exo-acting protein-alpha-N-acetylgalactosaminidase
Reaction catalysed
  • 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine
  • 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine
Comment(s)
  • The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it.
  • Unlike EC 3.2.1.49, it is not able to act on blood group A antigen.
Cross-references
BRENDA3.2.1.217
EC2PDB3.2.1.217
ExplorEnz3.2.1.217
PRIAM enzyme-specific profiles3.2.1.217
KEGG Ligand Database for Enzyme Nomenclature3.2.1.217
IUBMB Enzyme Nomenclature3.2.1.217
IntEnz3.2.1.217
MEDLINEFind literature relating to 3.2.1.217
MetaCyc3.2.1.217
Rhea expert-curated reactions3.2.1.217

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-