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ENZYME

ENZYME entry: EC 3.4.17.21

PURL: https://purl.expasy.org/enzyme/EC/3.4.17.21
Accepted Name
glutamate carboxypeptidase II
Alternative Name(s)
folate hydrolase
NAALADase
N-acetylated-gamma-linked-acidic dipeptidase
pteroylpoly-gamma-glutamate carboxypeptidase
Reaction catalysed
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates
Comment(s)
  • Hydrolyzes alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu and folylpoly-gamma- glutamates.
  • With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate.
  • Does not hydrolyze Ac-beta-Asp-Glu.
  • Inhibited by quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl- pentanedioate.
  • The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalyzed by EC 3.4.17.11 and EC 3.4.19.9.
  • Belongs to peptidase family M28.
  • Formerly EC 3.4.19.8.
Cross-references
BRENDA3.4.17.21
EC2PDB3.4.17.21
ExplorEnz3.4.17.21
KEGG Ligand Database for Enzyme Nomenclature3.4.17.21
IUBMB Enzyme Nomenclature3.4.17.21
MEDLINEFind literature relating to 3.4.17.21
MetaCyc3.4.17.21
Rhea expert-curated reactions3.4.17.21
UniProtKB/Swiss-Prot
Q04609, FOLH1_HUMANO35409, FOLH1_MOUSEO77564, FOLH1_PIG
P70627, FOLH1_RATD4B1R0, GCP1_ARTBCQ9M1S8, GCP2_ARATH
Q5WN23, GCP2_CAEBRP91406, GCP2_CAEELQ7Y228, LAMP1_ARATH
Q9Y3Q0, NALD2_HUMANQ9CZR2, NALD2_MOUSEQ852M4, PLAT3_ORYSJ
A0A1D6L709, VP8_MAIZE

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