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ENZYME

ENZYME entry: EC 3.4.21.100

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.100
Accepted Name
sedolisin
Alternative Name(s)
pseudomonalisin
pseudomonapepsin
Pseudomonas sp. pepstatin-insensitive carboxyl proteinase
sedolysin
Reaction catalysed
Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO2)-Arg-Leu
Comment(s)
  • An enzyme secreted by Pseudomonas sp. No. 101.
  • Optimum pH 4.
  • It is distinguished from EC 3.4.21.101 by its insensitivity to EPNP and from EC 3.4.23.31 by this property and by its unrelated amino- acid sequence.
  • Inhibited by tyrostatin, a peptide aldehyde.
  • Belongs to peptidase family S53.
  • Formerly EC 3.4.23.37.
Cross-references
BRENDA3.4.21.100
EC2PDB3.4.21.100
ExplorEnz3.4.21.100
KEGG Ligand Database for Enzyme Nomenclature3.4.21.100
IUBMB Enzyme Nomenclature3.4.21.100
MEDLINEFind literature relating to 3.4.21.100
MetaCyc3.4.21.100
Rhea expert-curated reactions3.4.21.100
UniProtKB/Swiss-Prot
P42790, PICP_PSESR

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