ENZYME entry: EC 3.4.21.100
Accepted Name |
sedolisin.
|
Alternative Name(s) |
pseudomonalisin. |
pseudomonapepsin. |
Pseudomonas sp. pepstatin-insensitive carboxyl proteinase. |
sedolysin. |
Reaction catalysed |
Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO2)-Arg-Leu |
Comment(s) |
- An enzyme secreted by Pseudomonas sp. No. 101.
- Optimum pH 4.
- It is distinguished from EC 3.4.21.101 by its insensitivity to EPNP
and from EC 3.4.23.31 by this property and by its unrelated amino-
acid sequence.
- Inhibited by tyrostatin, a peptide aldehyde.
- Belongs to peptidase family S53.
- Formerly EC 3.4.23.37.
|
Cross-references |
BRENDA | 3.4.21.100 |
EC2PDB | 3.4.21.100 |
ExplorEnz | 3.4.21.100 |
PRIAM enzyme-specific profiles | 3.4.21.100 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.100 |
IUBMB Enzyme Nomenclature | 3.4.21.100 |
IntEnz | 3.4.21.100 |
MEDLINE | Find literature relating to 3.4.21.100 |
MetaCyc | 3.4.21.100 |
Rhea expert-curated reactions | 3.4.21.100 |
UniProtKB/Swiss-Prot |
|
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