A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.100
| Accepted Name |
|---|
| Sedolisin.
|
| Alternative Name(s) |
|---|
| Pseudomonalisin. |
| Pseudomonapepsin. |
| Pseudomonas sp. pepstatin-insensitive carboxyl proteinase. |
| Sedolysin. |
| Reaction catalysed |
|---|
| Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO(2))-Arg-Leu |
| Comment(s) |
|---|
- An enzyme secreted by Pseudomonas sp. No. 101.
- Optimum pH 4.
- It is distinguished from EC 3.4.21.101 by its insensitivity to EPNP
and from EC 3.4.23.31 by this property and by its unrelated amino-
acid sequence.
- Inhibited by tyrostatin, a peptide aldehyde.
- Belongs to peptidase family S53.
- Formerly EC 3.4.23.37.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.100 |
| EC2PDB | 3.4.21.100 |
| ExplorEnz | 3.4.21.100 |
| PRIAM enzyme-specific profiles | 3.4.21.100 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.100 |
| IUBMB Enzyme Nomenclature | 3.4.21.100 |
| IntEnz | 3.4.21.100 |
| MEDLINE | Find literature relating to 3.4.21.100 |
| MetaCyc | 3.4.21.100 |
| UniProtKB/Swiss-Prot |
|
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-