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ENZYME

ENZYME entry: EC 3.4.21.105

Accepted Name
rhomboid protease
Reaction catalysed
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains
Comment(s)
  • These endopeptidases are multi-spanning membrane proteins.
  • Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains.
  • Important for embryo development in Drosophila melanogaster.
  • Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway.
  • Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
  • Belongs to peptidase family S54.
Cross-references
BRENDA3.4.21.105
EC2PDB3.4.21.105
ExplorEnz3.4.21.105
PRIAM enzyme-specific profiles3.4.21.105
KEGG Ligand Database for Enzyme Nomenclature3.4.21.105
IUBMB Enzyme Nomenclature3.4.21.105
IntEnz3.4.21.105
MEDLINEFind literature relating to 3.4.21.105
MetaCyc3.4.21.105
Rhea expert-curated reactions3.4.21.105
UniProtKB/Swiss-Prot
P46116, AARA_PROSTA8AQX4, GLPG_CITK8A7ZSV4, GLPG_ECO24
B7UKC8, GLPG_ECO27B7MDQ0, GLPG_ECO45B7L4V0, GLPG_ECO55
Q8X6Z6, GLPG_ECO57B5YTX6, GLPG_ECO5EB7NMI8, GLPG_ECO7I
B7N156, GLPG_ECO81B7M2I4, GLPG_ECO8AC4ZVX5, GLPG_ECOBW
B1X769, GLPG_ECODHA8A5N2, GLPG_ECOHSA1AGU7, GLPG_ECOK1
Q0TC44, GLPG_ECOL5Q8FCS5, GLPG_ECOL6B1IP42, GLPG_ECOLC
P09391, GLPG_ECOLIB7NE28, GLPG_ECOLUB6I2Y7, GLPG_ECOSE
B1LI84, GLPG_ECOSMQ1R5L1, GLPG_ECOUTA4WFK8, GLPG_ENT38
B7LSC6, GLPG_ESCF3P44783, GLPG_HAEINB5XTR5, GLPG_KLEP3
A6TF43, GLPG_KLEP7Q6CZL3, GLPG_PECASQ7N9W4, GLPG_PHOLL
B5F8P0, GLPG_SALA4A9MMA7, GLPG_SALARQ57IV1, GLPG_SALCH
B5FKE3, GLPG_SALDCB5R383, GLPG_SALEPB5R7J1, GLPG_SALG2
B4TKV0, GLPG_SALHSB4SVM1, GLPG_SALNSQ5PLZ8, GLPG_SALPA
B5BHH5, GLPG_SALPKB4TY77, GLPG_SALSVQ8Z229, GLPG_SALTI
Q8ZLH5, GLPG_SALTYA8GKU2, GLPG_SERP5B2U3N2, GLPG_SHIB3
Q31VK9, GLPG_SHIBSQ32AN6, GLPG_SHIDSQ0SZP2, GLPG_SHIF8
Q83PV6, GLPG_SHIFLQ3YWA4, GLPG_SHISSQ2NQH3, GLPG_SODGM
A1JSF0, GLPG_YERE8A7FNW6, GLPG_YERP3Q1C2L2, GLPG_YERPA
B2K5W4, GLPG_YERPBQ7CFX8, GLPG_YERPEQ1CCK6, GLPG_YERPN
A4TGR2, GLPG_YERPPQ664J1, GLPG_YERPSB1JHY8, GLPG_YERPY
P54493, GLUP_BACSUQ58EK4, PARLA_DANREQ2KHV4, PARL_BOVIN
A1Z8R8, PARL_DROMEQ9H300, PARL_HUMANQ5XJY4, PARL_MOUSE
Q5R5H4, PARL_PONABQ3B8P0, PARL_RATP53259, PCP1_YEAST
Q9CAN1, RBL2_ARATHO75783, RHBL1_HUMANQ8VC82, RHBL1_MOUSE
O88779, RHBL1_RATQ695U0, RHBL1_TOXGOQ9NX52, RHBL2_HUMAN
A2AGA4, RHBL2_MOUSEQ695T9, RHBL2_TOXGOP58872, RHBL3_HUMAN
P58873, RHBL3_MOUSEQ6IUY1, RHBL3_TOXGOQ8TEB9, RHBL4_HUMAN
Q8BHC7, RHBL4_MOUSEQ5RBS4, RHBL4_PONABQ4V8F3, RHBL4_RAT
Q695T8, RHBL4_TOXGOQ6GV23, RHBL5_TOXGOQ2PP52, RHBL6_TOXGO
Q19821, RHOM1_CAEELP20350, RHOM_DROME

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