ENZYME entry: EC 3.4.21.109
| Accepted Name |
|---|
| matriptase.
|
| Alternative Name(s) |
|---|
| epithin. |
| membrane-type serine protease 1. |
| MT-SP1. |
| prostamin. |
| serine endopeptidase SNC19. |
| serine protease 14. |
| serine protease TADG-15. |
| tumor-associated differentially-expressed gene 15 protein. |
| Reaction catalysed |
|---|
| Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position |
| Comment(s) |
|---|
- This trypsin-like integral-membrane serine peptidase has been
implicated in breast cancer invasion and metastasis.
- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by
cleavage of the two-chain form at an Arg residue to give active
alpha- and beta-HGF, but it does not activate plasminogen, which
shares high homology with HGF.
- The enzyme can also activate urokinase plasminogen activator (uPA),
which initiates the matrix-degrading peptidase cascade.
- Hemojuvelin has been shown to be a physiologic substrate for
matriptase-2.
- Belongs to peptidase family S1A.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.109 |
| EC2PDB | 3.4.21.109 |
| ExplorEnz | 3.4.21.109 |
| PRIAM enzyme-specific profiles | 3.4.21.109 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.109 |
| IUBMB Enzyme Nomenclature | 3.4.21.109 |
| IntEnz | 3.4.21.109 |
| MEDLINE | Find literature relating to 3.4.21.109 |
| MetaCyc | 3.4.21.109 |
| Rhea expert-curated reactions | 3.4.21.109 |
| UniProtKB/Swiss-Prot |
|
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