ENZYME entry: EC 3.4.21.109
Accepted Name |
Matriptase.
|
Alternative Name(s) |
Epithin. |
Membrane-type serine protease 1. |
MT-SP1. |
Prostamin. |
Serine endopeptidase SNC19. |
Serine protease 14. |
Serine protease TADG-15. |
Tumor-associated differentially-expressed gene 15 protein. |
Reaction catalysed |
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position |
Comment(s) |
- This trypsin-like integral-membrane serine peptidase has been
implicated in breast cancer invasion and metastasis.
- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by
cleavage of the two-chain form at an Arg residue to give active
alpha- and beta-HGF, but it does not activate plasminogen, which
shares high homology with HGF.
- Can also activate urokinase plasminogen activator (uPA), which
initiates the matrix-degrading peptidase cascade.
- Belongs to peptidase family S1A.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.109 |
EC2PDB | 3.4.21.109 |
ExplorEnz | 3.4.21.109 |
PRIAM enzyme-specific profiles | 3.4.21.109 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.109 |
IUBMB Enzyme Nomenclature | 3.4.21.109 |
IntEnz | 3.4.21.109 |
MEDLINE | Find literature relating to 3.4.21.109 |
MetaCyc | 3.4.21.109 |
Rhea expert-curated reactions | 3.4.21.109 |
UniProtKB/Swiss-Prot |
|
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