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ENZYME

ENZYME entry: EC 3.4.21.109

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.109
Accepted Name
matriptase
Alternative Name(s)
epithin
membrane-type serine protease 1
MT-SP1
prostamin
serine endopeptidase SNC19
serine protease 14
serine protease TADG-15
tumor-associated differentially-expressed gene 15 protein
Reaction catalysed
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment(s)
  • This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.
  • The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain forms at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high similarity with HGF.
  • The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade.
  • Hemojuvelin has been shown to be a physiologic substrate for matriptase-2.
  • Belongs to peptidase family S1A.
Cross-references
BRENDA3.4.21.109
EC2PDB3.4.21.109
ExplorEnz3.4.21.109
KEGG Ligand Database for Enzyme Nomenclature3.4.21.109
IUBMB Enzyme Nomenclature3.4.21.109
MEDLINEFind literature relating to 3.4.21.109
MetaCyc3.4.21.109
Rhea expert-curated reactions3.4.21.109
UniProtKB/Swiss-Prot
Q0IIH7, ST14_BOVINQ9Y5Y6, ST14_HUMANP56677, ST14_MOUSE

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