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ENZYME

ENZYME entry: EC 3.4.21.123

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.123
Accepted Name
kumamolysin
Alternative Name(s)
kumamolisin
Reaction catalysed
The enzyme preferentially hydrolyzes peptides having an Ala or Pro residue at P2 position and prefers such charged amino acid residues as Glu or Arg at the P2' position. In the oxidized insulin B chain, kumamolysin preferentially cleaves between Leu(15) and Tyr(16)
Comment(s)
  • This bacterial pepstatin-insensitive carboxyl proteinase has been isolated and characterized from Bacillus sp. MN-32 and from several Burkholderia spp.
  • Kumamolysin from Bacillus sp. MN-32 exhibits a Ser(278)/Glu(78)/Asp(82) catalytic triad.
  • The enzyme is a type example of peptidase family S53 in the MEROPS Peptidase Database.
Cross-references
BRENDA3.4.21.123
EC2PDB3.4.21.123
ExplorEnz3.4.21.123
KEGG Ligand Database for Enzyme Nomenclature3.4.21.123
IUBMB Enzyme Nomenclature3.4.21.123
MEDLINEFind literature relating to 3.4.21.123
MetaCyc3.4.21.123
Rhea expert-curated reactions3.4.21.123
UniProtKB/Swiss-Prot
Q8RR56, KSCP_BACX2

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