ENZYME entry: EC 3.4.21.34
Accepted Name |
plasma kallikrein.
|
Alternative Name(s) |
kininogenin. |
serum kallikrein. |
Reaction catalysed |
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin |
Comment(s) |
- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
- Activates coagulation factors XII, VII and plasminogen.
- Selective for Arg > Lys in P1, in small molecule substrates.
- Belongs to peptidase family S1.
- Formerly EC 3.4.4.21 and EC 3.4.21.8.
|
Cross-references |
BRENDA | 3.4.21.34 |
EC2PDB | 3.4.21.34 |
ExplorEnz | 3.4.21.34 |
PRIAM enzyme-specific profiles | 3.4.21.34 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.34 |
IUBMB Enzyme Nomenclature | 3.4.21.34 |
IntEnz | 3.4.21.34 |
MEDLINE | Find literature relating to 3.4.21.34 |
MetaCyc | 3.4.21.34 |
Rhea expert-curated reactions | 3.4.21.34 |
UniProtKB/Swiss-Prot |
|
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