A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.34
| Accepted Name |
|---|
| Plasma kallikrein.
|
| Alternative Name(s) |
|---|
| Kininogenin. |
| Serum kallikrein. |
| Reaction catalysed |
|---|
| Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin |
| Comment(s) |
|---|
- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
- Activates coagulation factors XII, VII and plasminogen.
- Selective for Arg > Lys in P1, in small molecule substrates.
- Belongs to peptidase family S1.
- Formerly EC 3.4.4.21 and EC 3.4.21.8.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 ; PDOC00376 |
| BRENDA | 3.4.21.34 |
| EC2PDB | 3.4.21.34 |
| ExplorEnz | 3.4.21.34 |
| PRIAM enzyme-specific profiles | 3.4.21.34 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.34 |
| IUBMB Enzyme Nomenclature | 3.4.21.34 |
| IntEnz | 3.4.21.34 |
| MEDLINE | Find literature relating to 3.4.21.34 |
| MetaCyc | 3.4.21.34 |
| UniProtKB/Swiss-Prot |
|
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