ENZYME entry: EC 3.4.21.41
Accepted Name |
Complement subcomponent C1r.
|
Reaction catalysed |
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42) |
Comment(s) |
- Activates C1s by proteolytic cleavage so that it can, in turn,
activate C2 and C4.
- Activated from proenzyme C1r in plasma by autocatalytic mechanism
during activation of the complement system by the 'classical' route.
- Belongs to peptidase family S1.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.41 |
EC2PDB | 3.4.21.41 |
ExplorEnz | 3.4.21.41 |
PRIAM enzyme-specific profiles | 3.4.21.41 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.41 |
IUBMB Enzyme Nomenclature | 3.4.21.41 |
IntEnz | 3.4.21.41 |
MEDLINE | Find literature relating to 3.4.21.41 |
MetaCyc | 3.4.21.41 |
Rhea expert-curated reactions | 3.4.21.41 |
UniProtKB/Swiss-Prot |
|
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