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ENZYME entry: EC 3.4.21.41

Accepted Name
Complement subcomponent C1r.
Reaction catalysed
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42)
Comment(s)
  • Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4.
  • Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.41
EC2PDB3.4.21.41
ExplorEnz3.4.21.41
PRIAM enzyme-specific profiles3.4.21.41
KEGG Ligand Database for Enzyme Nomenclature3.4.21.41
IUBMB Enzyme Nomenclature3.4.21.41
IntEnz3.4.21.41
MEDLINEFind literature relating to 3.4.21.41
MetaCyc3.4.21.41
Rhea expert-curated reactions3.4.21.41
UniProtKB/Swiss-Prot
Q8CG16, C1RA_MOUSE;  Q8CFG9, C1RB_MOUSE;  P00736, C1R_HUMAN;  
Q4R577, C1R_MACFA;  Q5R1W3, C1R_PANTR;  Q5R544, C1R_PONAB;  

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