Expasy logo

ENZYME

ENZYME entry: EC 3.4.21.41

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.41
Accepted Name
complement subcomponent C1r
Reaction catalysed
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42)
Comment(s)
  • Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4.
  • Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.41
EC2PDB3.4.21.41
ExplorEnz3.4.21.41
KEGG Ligand Database for Enzyme Nomenclature3.4.21.41
IUBMB Enzyme Nomenclature3.4.21.41
MEDLINEFind literature relating to 3.4.21.41
MetaCyc3.4.21.41
Rhea expert-curated reactions3.4.21.41
UniProtKB/Swiss-Prot
Q8CG16, C1RA_MOUSEQ8CFG9, C1RB_MOUSEP00736, C1R_HUMAN
Q4R577, C1R_MACFAQ5R1W3, C1R_PANTRQ5R544, C1R_PONAB

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-