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ENZYME entry: EC 3.4.21.42

Accepted Name
complement subcomponent C1s.
Alternative Name(s)
C1s esterase.
Reaction catalysed
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase
Comment(s)
  • Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.42
EC2PDB3.4.21.42
ExplorEnz3.4.21.42
PRIAM enzyme-specific profiles3.4.21.42
KEGG Ligand Database for Enzyme Nomenclature3.4.21.42
IUBMB Enzyme Nomenclature3.4.21.42
IntEnz3.4.21.42
MEDLINEFind literature relating to 3.4.21.42
MetaCyc3.4.21.42
Rhea expert-curated reactions3.4.21.42
UniProtKB/Swiss-Prot
Q0VCX1, C1S_BOVIN;  P09871, C1S_HUMAN;  Q69DK8, C1S_PIG;  
Q6P6T1, C1S_RAT;  Q8CG14, CS1A_MOUSE;  Q8CFG8, CS1B_MOUSE;  

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