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ENZYME entry: EC 3.4.21.6

Accepted Name
Coagulation factor Xa.
Alternative Name(s)
Prothrombase.
Prothrombinase.
Stuart factor.
Thrombokinase.
Reaction catalysed
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin
Comment(s)
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.6
EC2PDB3.4.21.6
ExplorEnz3.4.21.6
PRIAM enzyme-specific profiles3.4.21.6
KEGG Ligand Database for Enzyme Nomenclature3.4.21.6
IUBMB Enzyme Nomenclature3.4.21.6
IntEnz3.4.21.6
MEDLINEFind literature relating to 3.4.21.6
MetaCyc3.4.21.6
Rhea expert-curated reactions3.4.21.6
UniProtKB/Swiss-Prot
Q1L659, FA101_PSETE;  Q1L658, FA102_PSETE;  P00743, FA10_BOVIN;  
P25155, FA10_CHICK;  P00742, FA10_HUMAN;  O88947, FA10_MOUSE;  
O19045, FA10_RABIT;  Q63207, FA10_RAT;  Q4QXT9, FA10_TROCA;  
Q58L95, FAXC_OXYMI;  Q58L96, FAXC_OXYSU;  Q56VR3, FAXC_PSETE;  
A6MFK7, FAXD1_DEMVE;  P82807, FAXD1_NOTSC;  A6MFK8, FAXD2_DEMVE;  
Q58L94, FAXD2_NOTSC;  B5G6G5, FAXD_CRYNI;  P83370, FAXD_HOPST;  
P0CY52, FAXD_NOTSN;  Q58L93, FAXD_PSEPO;  P81428, FAXD_TROCA;  

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