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ENZYME

ENZYME entry: EC 3.4.21.6

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.6
Accepted Name
coagulation factor Xa
Alternative Name(s)
prothrombase
prothrombinase
Stuart factor
thrombokinase
Reaction catalysed
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin
Comment(s)
  • A blood coagulation factor formed from the proenzyme factor X by limited proteolysis.
  • Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds.
  • The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids.
  • Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.6
EC2PDB3.4.21.6
ExplorEnz3.4.21.6
KEGG Ligand Database for Enzyme Nomenclature3.4.21.6
IUBMB Enzyme Nomenclature3.4.21.6
MEDLINEFind literature relating to 3.4.21.6
MetaCyc3.4.21.6
Rhea expert-curated reactions3.4.21.6
UniProtKB/Swiss-Prot
Q1L659, FA101_PSETEQ1L658, FA102_PSETEP00743, FA10_BOVIN
P25155, FA10_CHICKP00742, FA10_HUMANO88947, FA10_MOUSE
O19045, FA10_RABITQ63207, FA10_RATQ4QXT9, FA10_TROCA
Q58L95, FAXC_OXYMIQ58L96, FAXC_OXYSUQ56VR3, FAXC_PSETE
A6MFK7, FAXD1_DEMVEP82807, FAXD1_NOTSCA6MFK8, FAXD2_DEMVE
Q58L94, FAXD2_NOTSCB5G6G5, FAXD_CRYNIP83370, FAXD_HOPST
P0CY52, FAXD_NOTSNQ58L93, FAXD_PSEPOP81428, FAXD_TROCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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