A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.6
| Accepted Name |
|---|
| Coagulation factor Xa.
|
| Alternative Name(s) |
|---|
| Prothrombase. |
| Prothrombinase. |
| Stuart factor. |
| Thrombokinase. |
| Reaction catalysed |
|---|
| Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin |
| Comment(s) |
|---|
- A blood coagulation factor formed from the proenzyme factor X by
limited proteolysis.
- Factor X is a glycoprotein composed of a heavy chain and a light
chain, which are generated from a precursor protein by the excision
of the tripeptide RKR and held together by one or more disulfide
bonds.
- The activated factor Xa converts prothrombin to thrombin in the
presence of factor Va, Ca(2+) and phospholipids.
- Scutelarin (EC 3.4.21.60) has similar specificity, but does not
require factor Va.
- Belongs to peptidase family S1.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.6 |
| EC2PDB | 3.4.21.6 |
| ExplorEnz | 3.4.21.6 |
| PRIAM enzyme-specific profiles | 3.4.21.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.6 |
| IUBMB Enzyme Nomenclature | 3.4.21.6 |
| IntEnz | 3.4.21.6 |
| MEDLINE | Find literature relating to 3.4.21.6 |
| MetaCyc | 3.4.21.6 |
| UniProtKB/Swiss-Prot |
| Q1L659, FA101_PSETE; | Q1L658, FA102_PSETE; | P00743, FA10_BOVIN; |
| P25155, FA10_CHICK; | P00742, FA10_HUMAN; | O88947, FA10_MOUSE; |
| O19045, FA10_RABIT; | Q63207, FA10_RAT; | Q4QXT9, FA10_TROCA; |
| Q58L95, FAXC_OXYMI; | Q58L96, FAXC_OXYSU; | Q56VR3, FAXC_PSETE; |
| A6MFK7, FAXD1_DEMVE; | P82807, FAXD1_NOTSC; | A6MFK8, FAXD2_DEMVE; |
| Q58L94, FAXD2_NOTSC; | B5G6G5, FAXD_CRYNI; | P83370, FAXD_HOPST; |
| P0CY52, FAXD_NOTSN; | Q58L93, FAXD_PSEPO; | P81428, FAXD_TROCA; |
|
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