ENZYME entry: EC 3.4.21.6
Accepted Name |
Coagulation factor Xa.
|
Alternative Name(s) |
Prothrombase. |
Prothrombinase. |
Stuart factor. |
Thrombokinase. |
Reaction catalysed |
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin |
Comment(s) |
- A blood coagulation factor formed from the proenzyme factor X by
limited proteolysis.
- Factor X is a glycoprotein composed of a heavy chain and a light
chain, which are generated from a precursor protein by the excision
of the tripeptide RKR and held together by one or more disulfide
bonds.
- The activated factor Xa converts prothrombin to thrombin in the
presence of factor Va, Ca(2+) and phospholipids.
- Scutelarin (EC 3.4.21.60) has similar specificity, but does not
require factor Va.
- Belongs to peptidase family S1.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.6 |
EC2PDB | 3.4.21.6 |
ExplorEnz | 3.4.21.6 |
PRIAM enzyme-specific profiles | 3.4.21.6 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.6 |
IUBMB Enzyme Nomenclature | 3.4.21.6 |
IntEnz | 3.4.21.6 |
MEDLINE | Find literature relating to 3.4.21.6 |
MetaCyc | 3.4.21.6 |
UniProtKB/Swiss-Prot |
Q1L659, FA101_PSETE; | Q1L658, FA102_PSETE; | P00743, FA10_BOVIN; |
P25155, FA10_CHICK; | P00742, FA10_HUMAN; | O88947, FA10_MOUSE; |
O19045, FA10_RABIT; | Q63207, FA10_RAT; | Q4QXT9, FA10_TROCA; |
Q58L95, FAXC_OXYMI; | Q58L96, FAXC_OXYSU; | Q56VR3, FAXC_PSETE; |
A6MFK7, FAXD1_DEMVE; | P82807, FAXD1_NOTSC; | A6MFK8, FAXD2_DEMVE; |
Q58L94, FAXD2_NOTSC; | B5G6G5, FAXD_CRYNI; | P83370, FAXD_HOPST; |
P0CY52, FAXD_NOTSN; | Q58L93, FAXD_PSEPO; | P81428, FAXD_TROCA; |
|
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UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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