ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.60

Accepted Name
Scutelarin.
Alternative Name(s)
Taipan activator.
Reaction catalysed
Selective cleavage of Arg-\|-Thr and Arg-\|-Ile in prothrombin to form thrombin and two inactive fragments
Comment(s)
From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca(2+) which binds via gamma-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. Formerly EC 3.4.99.28.
Cross-references
BRENDA	3.4.21.60
EC2PDB	3.4.21.60
ExplorEnz	3.4.21.60
PRIAM enzyme-specific profiles	3.4.21.60
KEGG Ligand Database for Enzyme Nomenclature	3.4.21.60
IUBMB Enzyme Nomenclature	3.4.21.60
IntEnz	3.4.21.60
MEDLINE	Find literature relating to 3.4.21.60
MetaCyc	3.4.21.60

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