ENZYME entry: EC 3.4.21.60
Accepted Name |
Scutelarin.
|
Alternative Name(s) |
Taipan activator. |
Reaction catalysed |
Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to form thrombin and two inactive fragments |
Comment(s) |
- From the venom of the Taipan snake (Oxyuranus scutellatus).
- Converts prothrombin to thrombin.
- Specificity is similar to that of Factor Xa (EC 3.4.21.6).
- However, unlike Factor Xa this enzyme can cleave its target in the
absence of coagulation Factor Va.
- Activity is potentiated by phospholipid and Ca(2+) which binds via
gamma-carboxyglutamic acid residues.
- Similar enzymes are known from the venom of other Australian elapid
snakes, including Pseudonaja textilis textilis, Oxyuranus
microlepidotus and Demansia nuchalis affinis.
- Formerly EC 3.4.99.28.
|
Cross-references |
BRENDA | 3.4.21.60 |
EC2PDB | 3.4.21.60 |
ExplorEnz | 3.4.21.60 |
PRIAM enzyme-specific profiles | 3.4.21.60 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.60 |
IUBMB Enzyme Nomenclature | 3.4.21.60 |
IntEnz | 3.4.21.60 |
MEDLINE | Find literature relating to 3.4.21.60 |
MetaCyc | 3.4.21.60 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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