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ENZYME entry: EC 3.4.21.68

Accepted Name
t-plasminogen activator.
Alternative Name(s)
tissue plasminogen activator.
tissue-type plasminogen activator.
tPA.
Reaction catalysed
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin
Comment(s)
  • From a wide variety of mammalian tissues, especially endothelial cells.
  • Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin.
  • Activity is considerably enhanced by fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
Cross-references
BRENDA3.4.21.68
EC2PDB3.4.21.68
ExplorEnz3.4.21.68
PRIAM enzyme-specific profiles3.4.21.68
KEGG Ligand Database for Enzyme Nomenclature3.4.21.68
IUBMB Enzyme Nomenclature3.4.21.68
IntEnz3.4.21.68
MEDLINEFind literature relating to 3.4.21.68
MetaCyc3.4.21.68
Rhea expert-curated reactions3.4.21.68
UniProtKB/Swiss-Prot
Q28198, TPA_BOVIN;  P00750, TPA_HUMAN;  P11214, TPA_MOUSE;  
Q8SQ23, TPA_PIG;  Q5R8J0, TPA_PONAB;  P19637, TPA_RAT;  
P98119, URT1_DESRO;  P15638, URT2_DESRO;  P98121, URTB_DESRO;  
P49150, URTG_DESRO;  

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