ENZYME entry: EC 3.4.21.68
Accepted Name |
t-plasminogen activator.
|
Alternative Name(s) |
tissue plasminogen activator. |
tissue-type plasminogen activator. |
tPA. |
Reaction catalysed |
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin |
Comment(s) |
- From a wide variety of mammalian tissues, especially endothelial
cells.
- Secreted as a single chain precursor which is cleaved to a two-chain
form by plasmin.
- Activity is considerably enhanced by fibrin.
- Belongs to peptidase family S1.
- Formerly EC 3.4.21.31 and EC 3.4.99.26.
|
Cross-references |
BRENDA | 3.4.21.68 |
EC2PDB | 3.4.21.68 |
ExplorEnz | 3.4.21.68 |
PRIAM enzyme-specific profiles | 3.4.21.68 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.68 |
IUBMB Enzyme Nomenclature | 3.4.21.68 |
IntEnz | 3.4.21.68 |
MEDLINE | Find literature relating to 3.4.21.68 |
MetaCyc | 3.4.21.68 |
Rhea expert-curated reactions | 3.4.21.68 |
UniProtKB/Swiss-Prot |
Q28198, TPA_BOVIN; | P00750, TPA_HUMAN; | P11214, TPA_MOUSE; |
Q8SQ23, TPA_PIG; | Q5R8J0, TPA_PONAB; | P19637, TPA_RAT; |
P98119, URT1_DESRO; | P15638, URT2_DESRO; | P98121, URTB_DESRO; |
P49150, URTG_DESRO; |
|
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