A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.68
| Accepted Name |
|---|
| T-plasminogen activator.
|
| Alternative Name(s) |
|---|
| Tissue plasminogen activator. |
| Tissue-type plasminogen activator. |
| tPA. |
| Reaction catalysed |
|---|
| Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin |
| Comment(s) |
|---|
- From a wide variety of mammalian tissues, especially endothelial
cells.
- Secreted as a single chain precursor which is cleaved to a two-chain
form by plasmin.
- Activity is considerably enhanced by fibrin.
- Belongs to peptidase family S1.
- Formerly EC 3.4.21.31 and EC 3.4.99.26.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.68 |
| EC2PDB | 3.4.21.68 |
| ExplorEnz | 3.4.21.68 |
| PRIAM enzyme-specific profiles | 3.4.21.68 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.68 |
| IUBMB Enzyme Nomenclature | 3.4.21.68 |
| IntEnz | 3.4.21.68 |
| MEDLINE | Find literature relating to 3.4.21.68 |
| MetaCyc | 3.4.21.68 |
| UniProtKB/Swiss-Prot |
| Q28198, TPA_BOVIN; | P00750, TPA_HUMAN; | P11214, TPA_MOUSE; |
| Q8SQ23, TPA_PIG; | Q5R8J0, TPA_PONAB; | P19637, TPA_RAT; |
| P98119, URT1_DESRO; | P15638, URT2_DESRO; | P98121, URTB_DESRO; |
| P49150, URTG_DESRO; |
|
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