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ENZYME

ENZYME entry: EC 3.4.21.69

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.69
Accepted Name
activated protein C (thrombin-activated peptidase)
Alternative Name(s)
activated blood coagulation factor XIV
autoprothrombin IIA
protein C (activated)
Reaction catalysed
Degradation of blood coagulation factors Va and VIIIa
Comment(s)
  • One of the gamma-carboxyglutamic acid-containing coagulation factors.
  • The enzyme plays an important role in regulating anticoagulation, inflammation, and cell death by proteolytically inactivating the blood coagulation factors factor Va and factor VIIIa.
  • Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin.
  • Protein C can also be activated by serine endopeptidases present in several snake venoms.
  • Belongs to peptidase family S1.
Cross-references
BRENDA3.4.21.69
EC2PDB3.4.21.69
ExplorEnz3.4.21.69
KEGG Ligand Database for Enzyme Nomenclature3.4.21.69
IUBMB Enzyme Nomenclature3.4.21.69
MEDLINEFind literature relating to 3.4.21.69
MetaCyc3.4.21.69
Rhea expert-curated reactions3.4.21.69
UniProtKB/Swiss-Prot
P00745, PROC_BOVINQ28278, PROC_CANLFQ28315, PROC_CAPHI
Q28412, PROC_FELCAQ28380, PROC_HORSEP04070, PROC_HUMAN
Q28506, PROC_MACMUP33587, PROC_MOUSEQ9GLP2, PROC_PIG
Q28661, PROC_RABITP31394, PROC_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-