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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.69

Accepted Name
Protein C (activated).
Alternative Name(s)
Activated blood coagulation factor XIV.
Autoprothrombin IIA.
Reaction catalysed
Degradation of blood coagulation factors Va and VIIIa
Comment(s)
  • One of the gamma-carboxyglutamic acid-containing coagulation factors.
  • Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.69
EC2PDB3.4.21.69
ExplorEnz3.4.21.69
PRIAM enzyme-specific profiles3.4.21.69
KEGG Ligand Database for Enzyme Nomenclature3.4.21.69
IUBMB Enzyme Nomenclature3.4.21.69
IntEnz3.4.21.69
MEDLINEFind literature relating to 3.4.21.69
MetaCyc3.4.21.69
UniProtKB/Swiss-Prot
P00745, PROC_BOVIN;  Q28278, PROC_CANLF;  Q28315, PROC_CAPHI;  
Q28412, PROC_FELCA;  Q28380, PROC_HORSE;  P04070, PROC_HUMAN;  
Q28506, PROC_MACMU;  P33587, PROC_MOUSE;  Q9GLP2, PROC_PIG;  
Q28661, PROC_RABIT;  P31394, PROC_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-