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ENZYME entry: EC 3.4.21.72

Accepted Name
IgA-specific serine endopeptidase.
Alternative Name(s)
IgA protease.
immunoglobulin A1 protease.
Reaction catalysed
Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known
Comment(s)
  • Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae.
  • Some other bacterial endopeptidases with similar specificity are of metallotype (see EC 3.4.24.13).
  • Belongs to peptidase family S6.
Cross-references
BRENDA3.4.21.72
EC2PDB3.4.21.72
ExplorEnz3.4.21.72
PRIAM enzyme-specific profiles3.4.21.72
KEGG Ligand Database for Enzyme Nomenclature3.4.21.72
IUBMB Enzyme Nomenclature3.4.21.72
IntEnz3.4.21.72
MEDLINEFind literature relating to 3.4.21.72
MetaCyc3.4.21.72
Rhea expert-curated reactions3.4.21.72
UniProtKB/Swiss-Prot
P44969, IGA0_HAEIN;  P42782, IGA1_HAEIF;  P45384, IGA2_HAEIF;  
P45385, IGA3_HAEIF;  P45386, IGA4_HAEIF;  P09790, IGA_NEIGO;  

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