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ENZYME entry: EC 3.4.21.73

Accepted Name
u-plasminogen activator.
Alternative Name(s)
cellular plasminogen activator.
urinary plasminogen activator.
urokinase.
Reaction catalysed
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin
Comment(s)
  • Formed from the inactive precursor by action of plasmin or plasma kallikrein.
  • Differs in structure from EC 3.4.21.68, and does not bind to fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
Cross-references
BRENDA3.4.21.73
EC2PDB3.4.21.73
ExplorEnz3.4.21.73
PRIAM enzyme-specific profiles3.4.21.73
KEGG Ligand Database for Enzyme Nomenclature3.4.21.73
IUBMB Enzyme Nomenclature3.4.21.73
IntEnz3.4.21.73
MEDLINEFind literature relating to 3.4.21.73
MetaCyc3.4.21.73
Rhea expert-curated reactions3.4.21.73
UniProtKB/Swiss-Prot
Q05589, UROK_BOVIN;  P15120, UROK_CHICK;  P00749, UROK_HUMAN;  
P06869, UROK_MOUSE;  P16227, UROK_PAPCY;  P04185, UROK_PIG;  
Q5RF29, UROK_PONAB;  Q8MHY7, UROK_RABIT;  P29598, UROK_RAT;  

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