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ENZYME entry: EC 3.4.21.74

Accepted Name
Venombin A.
Reaction catalysed
Selective cleavage of Arg-|-Xaa bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme
Comment(s)
  • A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group.
  • Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper), batroxobin from Bothrops atrox (South American pit viper) and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake).
  • Does not require activation by calcium.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.28, EC 3.4.21.29 and EC 3.4.21.30.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.74
EC2PDB3.4.21.74
ExplorEnz3.4.21.74
PRIAM enzyme-specific profiles3.4.21.74
KEGG Ligand Database for Enzyme Nomenclature3.4.21.74
IUBMB Enzyme Nomenclature3.4.21.74
IntEnz3.4.21.74
MEDLINEFind literature relating to 3.4.21.74
MetaCyc3.4.21.74
UniProtKB/Swiss-Prot
P05620, VSP1_PROFL;  P81661, VSPA_BOTJA;  F8S114, VSPCR_CROAD;  
P26324, VSPF1_CALRH;  P47797, VSPF2_CALRH;  P04971, VSPF_BOTAT;  
Q9PS28, VSPF_CERCE;  Q9PRP4, VSPF_LACMR;  P33589, VSPF_LACMU;  
P0DJ86, VSPL_BOTLC;  

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